Epidemiological studies have shown that 70-90 % of all cancers are caused due to the chemicals present in environment. Exogenous exposure to carcinogens and their interaction with genetic sequences and endogenous factors, like exposures to products of metabolism which lead to acute stress, disruption of hormones and inflammation of tissues, are triggering factors. Due to relatively small risk of cancer following immediate exposure, the precise quantification of the burden of human cancer attributed to environmental exposure remains ambiguous, thereby leading to an assumption that a causal relationship is relatively large. Research suggests that 90-95 % of all cancers have their roots in the environmental effects on the DNA leading to genetic defects, whereas only 5-10 % can be attributed to inherited genetic defects. The hypothesis of the present review is that response of the cells to the environmental stimulants could be an evolutionary process of adaptation of the DNA. Carcinogenesis is considered as a process of adaptation of mammalian cells to sustained stress environment (SSE) by means of epigenetic alteration (EA) of the genome, mutations which arise due to EA and finally, natural selection of originated mutant cells evading apoptosis. Process of adaptation to SSE involves the emergence of senescent epigenetically reprogrammed cells with specific cancerrelated EA in the genome.
Background: The ongoing pandemic caused by human coronavirus SARS CoV-2 has led to millions of death across the globe. Not only the virus is highly infectious, it is also mutates very easily. Currently there are no approved drugs for the therapeutic cure of COVID-19. The world is in search for an alternative that has antiviral properties directed against virus. Objective: The present study investigates an Ayurvedic polyherbal formulation of 13 herbs, named NOQ19, targeted against various viral proteins of COVID-19. Methodology: The study is a single arm, single centric, open label study of 161 RT-PCR positive COVID-19 patients. The enrolled participants were given the ayurvedic intervention, 2 tablets, thrice daily, to be consumed along with the standard care. Follow up COVID-19 RT- PCR was done on Day 5, Day 10 and Day 14 or until the patient turned negative. The time required for turning RT-PCR negative or become asymptomatic was noted. Results: Subjective analysis demonstrated that 98% of patients turned asymptomatic within 5 days of NOQ19 intake. Also 74% of the subjects turned RT-PCR Negative on Day 5 after taking NOQ19 along with the standard care provided. Also, none of the participant reported any adverse effect or side effect to the medication.Conclusion: NOQ19 Ayurvedic polyherbal formulation is an effective as well as safe alternative and adjunct treatment for the symptomatic management of COVID-19.
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