Epigenetic silencing of TET1 mediated hydroxymethylation of base excision repair pathway during lung carcinogenesis

Chen, Hongqiang; Chen, Dong-jiao; Li, Yan; Yuan, Wenwen; Fan, Jia; Zhang, Zhe; Han, Fei; Jiang, Xiao; Chen, Jianping; Wang, Dandan; Cao, Jia; Liu, Jinyi; Liu, Wenbin

doi:10.1016/j.envpol.2020.115860

Cited by 6 publications

(5 citation statements)

References 45 publications

(58 reference statements)

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“…Moreover, methylation levels gradually increased. Blocking OGG1 significantly attenuated the effect of TET1 [ 31 ]. This is due to the ability of OGG1 to target and bind to 8-oxoG and then recruit the dioxygenase TET1 to oxidize 5-methylcytosine (5-mC) adjacent to 8-oxoG to form 5-hydroxymethylcytosine (5-hmC), thereby initiating DNA demethylation [ 32 ] ( Figure 1 ).…”

Section: The Role Of Ogg1 In Dna Oxidative Damage Repairmentioning

confidence: 99%

Effect of 8-Hydroxyguanine DNA Glycosylase 1 on the Function of Immune Cells

Zhang

Zhong

et al. 2023

Antioxidants

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Excess reactive oxygen species (ROS) can cause an imbalance between oxidation and anti-oxidation, leading to the occurrence of oxidative stress in the body. The most common product of ROS-induced base damage is 8-hydroxyguanine (8-oxoG). Failure to promptly remove 8-oxoG often causes mutations during DNA replication. 8-oxoG is cleared from cells by the 8-oxoG DNA glycosylase 1 (OGG1)-mediated oxidative damage base excision repair pathway so as to prevent cells from suffering dysfunction due to oxidative stress. Physiological immune homeostasis and, in particular, immune cell function are vulnerable to oxidative stress. Evidence suggests that inflammation, aging, cancer, and other diseases are related to an imbalance in immune homeostasis caused by oxidative stress. However, the role of the OGG1-mediated oxidative damage repair pathway in the activation and maintenance of immune cell function is unknown. This review summarizes the current understanding of the effect of OGG1 on immune cell function.

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Section: The Role Of Ogg1 In Dna Oxidative Damage Repairmentioning

confidence: 99%

Effect of 8-Hydroxyguanine DNA Glycosylase 1 on the Function of Immune Cells

Zhang

Zhong

et al. 2023

Antioxidants

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“…However, the expression changes in TETs, especially for TET2 and TET3, in lung cancer remain somewhat unclear, with conflicting observations for TET1 in cell lines and primary tumor models. Recent studies based primarily on cell line models proposed a feedback loop mechanism where TET1 is directly downregulated by a DNA promoter methylation mechanism when normal cells are exposed to carcinogens, further shifting the balance towards CpG methylation at TSGs (e.g., ABE1 , HOXA9 , HOXA7 , OGG1 , TIMP , and XRCC1 ) and their inactivation [ 70 , 71 ]. In contrast, a separate study reported that TET1 is frequently upregulated (from 2- to 90-fold in 40–70% tumors) and acts as an oncogene in LUAD and LUSC primary tumors with a p53 loss of function [ 72 ].…”

Section: Dna Methylation Dysregulation In Lung Cancermentioning

confidence: 99%

DNA Methylation in Lung Cancer: Mechanisms and Associations with Histological Subtypes, Molecular Alterations, and Major Epidemiological Factors

Hoang

Landi

2022

Cancers

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Lung cancer is the major leading cause of cancer-related mortality worldwide. Multiple epigenetic factors—in particular, DNA methylation—have been associated with the development of lung cancer. In this review, we summarize the current knowledge on DNA methylation alterations in lung tumorigenesis, as well as their associations with different histological subtypes, common cancer driver gene mutations (e.g., KRAS, EGFR, and TP53), and major epidemiological risk factors (e.g., sex, smoking status, race/ethnicity). Understanding the mechanisms of DNA methylation regulation and their associations with various risk factors can provide further insights into carcinogenesis, and create future avenues for prevention and personalized treatments. In addition, we also highlight outstanding questions regarding DNA methylation in lung cancer to be elucidated in future studies

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“…Studies over the impact of OGG1 on lung cancer also did not reach a consensus. Researchers reported that TET1 regulated the balance of hydroxymethylation and methylation in the promoter region of BER related genes, which participates in the development of lung cancer induced by environmental chemicals [103], and in the tumor tissues of smoking patients with non-small cell lung carcinoma. The activity of hOGG1 was significantly higher compared with control samples, whereas the activity of endonuclease III homologue (hNTH1) was lower.…”

Section: The Roles Of Ogg1 In Lung Cancermentioning

confidence: 99%

“…Researchers performed an imitation of the OGG1-BER process by attacking mice lungs using 8-oxoG. In total, 1592 transcripts were identified by RNA-seq analysis [103]. The up-regulated mRNA was associated with biological processes, including homeostasis, immune system, macrophage activation, surface tension regulation and response to stimuli.…”

Section: The Roles Of Ogg1 In Airway Remodeling and Asthmamentioning

confidence: 99%

OGG1 in Lung—More than Base Excision Repair

Xiang

2022

Antioxidants

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As the organ executing gas exchange and directly facing the external environment, the lungs are challenged continuously by various stimuli, causing the disequilibration of redox homeostasis and leading to pulmonary diseases. The breakdown of oxidants/antioxidants system happens when the overproduction of free radicals results in an excess over the limitation of cleaning capability, which could lead to the oxidative modification of macromolecules including nucleic acids. The most common type of oxidative base, 8-oxoG, is considered the marker of DNA oxidative damage. The appearance of 8-oxoG could lead to base mismatch and its accumulation might end up as tumorigenesis. The base 8-oxoG was corrected by base excision repair initiated by 8-oxoguanine DNA glycosylase-1 (OGG1), which recognizes 8-oxoG from the genome and excises it from the DNA double strand, generating an AP site for further processing. Aside from its function in DNA damage repairment, it has been reported that OGG1 takes part in the regulation of gene expression, derived from its DNA binding characteristic, and showed impacts on inflammation. Researchers believe that OGG1 could be the potential therapy target for relative disease. This review intends to make an overall summary of the mechanism through which OGG1 regulates gene expression and the role of OGG1 in pulmonary diseases.

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Epigenetic silencing of TET1 mediated hydroxymethylation of base excision repair pathway during lung carcinogenesis

Cited by 6 publications

References 45 publications

Effect of 8-Hydroxyguanine DNA Glycosylase 1 on the Function of Immune Cells

Effect of 8-Hydroxyguanine DNA Glycosylase 1 on the Function of Immune Cells

DNA Methylation in Lung Cancer: Mechanisms and Associations with Histological Subtypes, Molecular Alterations, and Major Epidemiological Factors

OGG1 in Lung—More than Base Excision Repair

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