Environmental Contamination with Cyclophosphamide, Ifosfamide, and Methotrexate: A Study of 51 Canadian Centres

Janes, Alexia; Tanguay, Cynthia; Caron, Nicolas; Bussières, Jean-François

doi:10.4212/cjhp.v68i4.1467

Cited by 18 publications

(14 citation statements)

References 13 publications

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“…But also efforts in technical equipment and hygienic strategies could have contributed to this progress. A time trend has also been reported in Canadian hospitals for other ADs with a substantial (4-5-times) decrease of the 75th percentile of contamination concentration over several years [14,48] while the proportion of positive results remained approximately constant. Likewise, European studies described a reduction in surface contamination over time for various ADs [27,28,31,49].…”

Section: Long-term Monitoring Of Surface Contaminationmentioning

confidence: 65%

“…Therefore, healthcare professionals still remain at potential exposure risk. This has been documented for nearly three decades of investigation and is nevertheless an actual issue because no health-based limit for these agents can actually be defined [10][11][12][13][14][15][16][17][18][19]. An expanded bibliography of publications on this topic has been compiled by the National Institute for Occupational Safety and Health (http://www.cdc.gov/niosh/topics/antineoplastic/pubs.…”

Section: Introductionmentioning

confidence: 99%

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Benefits of Wipe Sampling: Evaluation of Long-Term 5-Fluorouracil and Platinum Monitoring Data

Böhlandt

Schierl

2016

Pharmaceutical Technology in Hospital Pharmacy

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AbstractObjectives:The aim of this study was to evaluate environmental contamination levels from a large dataset of long-term monitoring data of 5-fluorouracil and platinum-containing drugs in pharmacies, and to investigate the contaminations over 15 years.Methods:Wipe sampling for 5-fluorouracil and platinum (marker for cis-, carbo- and oxaliplatin) was performed on-site from various surfaces in hospital and retail pharmacies with a validated sampling procedure over a period of 15 years. The 5-fluorouracil concentrations were quantified by GCMSMS and platinum concentrations by voltammetry. Statistical evaluation was performed with respect to sampling locations and years, and over the course of time.Results:Overall, 3,584 wipe samples for 5-fluorouracil and 2,955 wipe samples for platinum were analysed and contamination was detected at all surface types in all 151 examined pharmacies with ranges from ND (not detectable) to 1,725,000 pg/cm² and ND to 23,068 pg/cm², respectively. Median concentrations from the different locations ranged between ND and 4.3 pg/cm² (5-fluorouracil) and 0.2 and 1.8 pg/cm² (platinum) with highest loads inside the biological safety cabinets/isolators and storage areas. Evaluation of contamination over the course of 15 years showed a substantial decrease, especially in the years after introduction of guidance values.Conclusions:Long-term evaluation of surface wipe samples for antineoplastic drug contamination with repeated monitoring seems to be a beneficial tool to characterize the actual exposure situation and to assess surface contamination over time. Wipe sampling is a suitable control means to evaluate the work practices and the effectiveness of applied safety and hygiene measures and to identify the potential exposure risk for health care workers.

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Section: Long-term Monitoring Of Surface Contaminationmentioning

confidence: 65%

Section: Introductionmentioning

confidence: 99%

Benefits of Wipe Sampling: Evaluation of Long-Term 5-Fluorouracil and Platinum Monitoring Data

Böhlandt

Schierl

2016

Pharmaceutical Technology in Hospital Pharmacy

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“…Unfortunately, the few studies conducted on HD exposure and human uptake in the OR setting have been largely confined to hyperthermic intraoperative peritoneal chemotherapy administration, which is very different from an ophthalmologic procedure and carries its own particular exposure risks . However, studies conducted outside the OR continue to demonstrate how HD residue can spread and contaminate the environment . For example, researchers have identified HD residue on computer keyboards, mice, and pens, which are items not normally associated with the administration of HDs.…”

Section: Hd Safety Challengesmentioning

confidence: 99%

Applying Hazardous Drug Standards to Antineoplastics Used for Ophthalmology Surgery

Eisenberg¹,

Pacheco²

2018

AORN Journal

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“…4,9,10 Most of the reported methods are based on the use of liquid chromatography (LC) coupled with UV spectrophotometry (UV) 11,12,13,14 or mass spectrometry (MS), when there was a need for high selectivity and/or sensitivity. [15][16][17][18][19][20][21][22]23,24,25,26,27,28,29,30,31,32,33,34 Limits of detection 51 In our opinion, ELSD is not recommended for analysing pemetrexed since this molecule is UV-active and ELSD is often less sensitive and selective than the commonly used UV detectors. A methodology including a PP step followed by LC-MS analysis was also developed for the determination of raltitrexed in human plasma with a limit of quantification (LOQ) of 2 ng mL −1 .…”

Section: Antimetabolitesmentioning

confidence: 99%

Antineoplastic drugs and their analysis: a state of the art review

Guichard

Guillarme

Bonnabry

et al. 2017

Analyst

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The number of patients suffering from cancer is constantly increasing and, consequently, the number of different chemotherapy treatments administered is increasing. Given the high reactivity and toxicity of antineoplastic drugs, analytical methods are required in all pharmaceutical fields, from drug development to their elimination in wastewater; including formulation quality control, environment and human exposure and therapeutic drug monitoring. The aim of this paper is to provide an overview of the analytical methods available for the determination of antineoplastic drugs in different matrices such as pharmaceutical formulations, biological and environmental samples. The applicability and performance of the reported methods will be critically discussed, with focus on the most commonly used antineoplastic drugs. Only conventional compounds and small molecules for targeted therapy will be considered in the present review.

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Environmental Contamination with Cyclophosphamide, Ifosfamide, and Methotrexate: A Study of 51 Canadian Centres

Abstract: Background: Occupational exposure to hazardous drugs may lead to adverse reproductive effects. There is no safe exposure limit for health care professionals.

Cited by 18 publications

References 13 publications

Benefits of Wipe Sampling: Evaluation of Long-Term 5-Fluorouracil and Platinum Monitoring Data

Benefits of Wipe Sampling: Evaluation of Long-Term 5-Fluorouracil and Platinum Monitoring Data

Applying Hazardous Drug Standards to Antineoplastics Used for Ophthalmology Surgery

Antineoplastic drugs and their analysis: a state of the art review

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