Antineoplastic drugs and their analysis: a state of the art review

Abstract

The number of patients suffering from cancer is constantly increasing and, consequently, the number of different chemotherapy treatments administered is increasing. Given the high reactivity and toxicity of antineoplastic drugs, analytical methods are required in all pharmaceutical fields, from drug development to their elimination in wastewater; including formulation quality control, environment and human exposure and therapeutic drug monitoring. The aim of this paper is to provide an overview of the analytical methods available for the determination of antineoplastic drugs in different matrices such as pharmaceutical formulations, biological and environmental samples. The applicability and performance of the reported methods will be critically discussed, with focus on the most commonly used antineoplastic drugs. Only conventional compounds and small molecules for targeted therapy will be considered in the present review.

Synthesis and Antiproliferative Evaluation of Novel Longifolene-Derived Tetralone Derivatives Bearing 1,2,4-Triazole Moiety

“…Due to their high toxicity, drug resistance, and the gastrointestinal discomfort associated with their use, lots of structural modifications have been carried out; consequently, some derivatives with better performance, such as NK611, NPF, GL-331, and TOP53, have been discovered and tested in clinical trials [2]. The tetralin ring also exists in the structures of some clinically used anticancer drugs, for example, the anthracycline antibiotics doxorubicin, daunorubicin, epirubicin, and idarubicin [3], and so on. Many studies have been performed on tetralin derivatives for use as efficient antitumor agents [4][5][6][7][8][9].…”

Probiotics, Prebiotics, Synbiotics, and Paraprobiotics as a Therapeutic Alternative for Intestinal Mucositis

“…Antineoplastic chemotherapy consists of the use of drugs that destroy cancer cells, inhibit their growth, and prevent their spread by targeting DNA or critical processes involved in cell division (Guichard et al, 2017;Shields, 2017). The traditional chemotherapeutics are classified according to their mechanisms of action, including antimetabolites, microtubule-targeting agents, topoisomerases, and antibiotics (Shields, 2017).…”

Development of cost‐effective RP‐HPLC methods for detection of cyclophosphamide, etoposide and paclitaxel

“…Although there are several literatures on individual or simultaneous detection of paclitaxel, cyclophosphamide and etoposide [2,8,[14][15][16][17], these reported methods usually require very costly solvent as a mobile phase. Therefore, there is a need for simple and low cost technique to detect these compounds.…”