Benefits of Wipe Sampling: Evaluation of Long-Term 5-Fluorouracil and Platinum Monitoring Data

Böhlandt, Antje; Schierl, Rudolf

doi:10.1515/pthp-2016-0010

Cited by 8 publications

(10 citation statements)

References 40 publications

(52 reference statements)

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“…Therefore, some authors have introduced the percentile values as reference values for a substance-independent guideline, in order to interpret the data obtained by monitoring exposure risk at hospital workplaces. These studies conducted on high number of samples have proposed hygienic guidance values for surface wipe sampling based on 75th percentiles and 95th percentile [19,20]. Recently, surface exposure levels (SELs) for 21 ADs based on 75th and 90th percentile values were proposed by Dugheri et al [21] both for preparation and administration units joined with a traffic-light color-coding system.…”

Section: Introductionmentioning

confidence: 99%

Monitoring surface contamination for thirty antineoplastic drugs: a new proposal for surface exposure levels (SELs)

Dugheri

Mucci²,

Bucaletti³

et al. 2022

Med Pr

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Background: Chemotherapy drugs are widely used to treat cancer, but their active compounds represent a danger for workers who could be exposed to them. However, they aren't yet included in directive CE No. 1272/2008 and the European Biosafety Network has only recommended a limit value of 100 pg/cm 2 for surface contamination. Thus, it is crucial to assess surface contaminations in healthcare environments. Currently, the technique of choice is surface wipe test combined with liquid chromatography tandem mass spectrometry to achieve high sensibility. Material and Methods: A campaign involving Careggi University Hospital (Florence, Italy) was performed from January 2020 to December 2021, collecting 1449 wipe samples between administration units, preparation unit, and personnel gloves. From the obtained data, the 90th percentile was calculated for 30 antiblastic drugs and proposed as surface exposure levels (SELs); while from data concerning personnel glove contamination, weekly contamination was estimated. Results: In the 2-year period only 417 wipe samples were found positive (28.8%), the majority of which regard samples coming from administration unit bathrooms. The proposed SELs are almost all <100 pg/cm 2 , except for few drugs which produce higher contamination on bathroom surfaces. Also, the estimation of pharmacy personnel's glove contamination highlighted very low results (ng/week). Conclusions: Deeply established protocols and procedures for safe handling of ADs allow for obtaining excellent cleaning results and thus a safer work environment, however, the risk of cytostatic contaminations cannot be avoided in healthcare workplaces, and thus a harmonization of classification and labeling of chemotherapy drugs throughout the European Union should be done. Med Pr. 2022;73(5)

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Section: Introductionmentioning

confidence: 99%

Monitoring surface contamination for thirty antineoplastic drugs: a new proposal for surface exposure levels (SELs)

Dugheri

Mucci²,

Bucaletti³

et al. 2022

Med Pr

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“…Kiffmeyer et al [19], instead, produced a substance-independent guideline based on the 90th percentile values of the 8 chemotherapy drugs found in the highest concentrations in a large-scale German study. Stricter threshold guidance values for platinum (Pt) and 5-fluorouracil (5-FU), such as the 50th or 75th percentile, were suggested by a German research group [10,20]. In addition, Hedmer et al [21] reported hygienic guidance values (HGVs) for CP and ifosfamide (IP) in different categories of surfaces for hospital workplaces.…”

Section: Introductionmentioning

confidence: 99%

Analytical strategies for assessing occupational exposure to antineoplastic drugs in healthcare workplaces

Dugheri¹,

Bonari²,

Pompilio³

et al. 2018

Med Pr

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Background: Cytotoxic antineoplastic drugs (ADs), widely used in treating cancer, are considered hazardous in the workplace and thus require safe handling practices. An analytical protocol for environmental and biological AD monitoring in the healthcare environment has been developed, since Europe lacks clear guidelines and regulations for cytostatic preparation and handling. Material and Methods: Liquid chromatography-tandem mass spectrometry (LC-MS/MS) was used for measuring contemporaneously 20 multi-class cytostatic compounds and urinary α-fluoro-β-alanine, whereas platinum was detected by inductively coupled plasma mass spectrometry (ICP-MS). Sampling procedures and analytical conditions were optimized and the assays were validated. Environmental AD monitoring data, collected in 2009-2017, for a total of 3749 wipe tests and 57 720 determinations, was evaluated. Results: The proportion of positive samples gradually decreased from 11.7% in 2010 to 1% in 2017, however, 2266 determinations were positive. No urine sample had detectable concentrations of any of the 4 drugs considered (0/398 samples). Conclusions: These improvements are so large that the key role played by the new, more stringent rules for preparing and administering ADs is evident. Hence, the analytical method involving multi-element determinations allows for a more thorough and complete investigation into the AD contamination of work environments.

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“…e Raiden mobile positioning system has safety, accuracy, low cost, and practicality. e main function of the signal acquisition and transmission subsystem is to collect electromagnetic wave signals during lightning strikes, convert them into digital signals, and select and store the required data, or directly transmit them to the central information location in data processing and integrated production [17].…”

Section: Platform Design Of Lightning Monitoring and Positioningmentioning

confidence: 99%

Forecast of Thunderstorm Cloud Trend Based on Monitoring Data of Thunder Mobile Positioning System

Yang

Liu

2021

Mobile Information Systems

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As a natural phenomenon, thunder and lightning have a major impact on human production and life. As an important part of lightning protection technology, the main task of the lightning mobile positioning system is to detect and determine the location of lightning and, at the same time, provide more accurate lightning discharge parameters for lightning research. It is a new technology that serves the entire society and is in urgent need of development. This paper aims to study the trend prediction of thunderstorm cloud based on the monitoring data of the thunder and lightning mobile positioning system. In this thesis, the inverse distance-weighted interpolation method can be used to determine the lightning area and the principle of lightning monitoring and positioning, and the classification of lightning and the practical significance of lightning mobile positioning system monitoring are also studied. Finally, the Hurst index of this paper can reveal the trend elements in the time series well through the experiment, so as to judge the lightning strikes. At the same time, it also introduces everyone’s satisfaction survey on the lightning mobile positioning system. The results of this paper show that the lightning mobile positioning system has been widely used in our country’s meteorological monitoring stations, and it plays a very important role in our national defense lightning strikes and effectively realizes the lightning strike prediction in the monitoring process, which can better enable the competent department to take timely and accurate measures to prevent lightning strikes. Experimental analysis shows that the accuracy of the lightning mobile positioning system has reached 92%, and the practicability has reached 88%.

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Benefits of Wipe Sampling: Evaluation of Long-Term 5-Fluorouracil and Platinum Monitoring Data

Cited by 8 publications

References 40 publications

Monitoring surface contamination for thirty antineoplastic drugs: a new proposal for surface exposure levels (SELs)

Monitoring surface contamination for thirty antineoplastic drugs: a new proposal for surface exposure levels (SELs)

Analytical strategies for assessing occupational exposure to antineoplastic drugs in healthcare workplaces

Forecast of Thunderstorm Cloud Trend Based on Monitoring Data of Thunder Mobile Positioning System

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