Enumeration and functional investigation of endothelial progenitor cells in neovascularization of diabetic foot ulcer rats with a Chinese 2‐herb formula

Abstract

NF3 modulated diabetic wound healing through regulation of systemic EPCs level and increase in local vascular formation.

Predictive value of neutrophil-to-lymphocyte ratio in diabetic wound healing

“…24 This endothelial dysfunction can lead to worse outcomes in the setting of diabetic wounds. 25 Recently, some studies have shown that NLR can be an indicating marker of infection and its severity. 26,27 However, in our study, after adjusting for several risk factors including wound infection, blood glucose levels, and cardiovascular risk factors, NLR could predict complete healing with OR of 3.45 ( P = .01).…”

Isolation of endothelial progenitor cells from human adipose tissue

“…It has been noted in some previous studies that EPCs are detected, and only at low numbers, in umbilical cord blood (Finney et al, 2006;Lin et al, 2011;Moon et al, 2013;Phuc et al, 2012), bone marrow (Ii, 2010) and peripheral blood (Donndorf et al, 2015). These EPCs have been successfully applied to treat ischemia-related diseases, such as hindlimb ischemia (Flex et al, 2016;Yu et al, 2015), stroke (Bai et al, 2015;Li et al, 2015), diabetic ulcer (Barcelos et al, 2009;Tam et al, 2015), and myocardial infarction (Mehmood et al, 2015;Sheng et al, 2015).…”

“…EPCs are another group of important stem cells; they exhibit strong angiogenesis potential and play a key role in vasculogenesis and angiogenesis (Chong et al, 2016). EPCs have been used effectively to treat hindlimb ischemia (Flex et al, 2016;Yu et al, 2015), stroke (Bai et al, 2015;Li et al, 2015), diabetic ulcer (Barcelos et al, 2009;Tam et al, 2015), and myocardial infarction (Mehmood et al, 2015;Sheng et al, 2015). However, the greatest limitation of EPC-based transplantation is the scarcity of EPCs; unlike other stem cells, EPCs exist in umbilical cord blood (Finney et al, 2006;Lin et al, 2011;Moon et al, 2013;Phuc et al, 2012), bone marrow (Ii, 2010) and peripheral blood (Donndorf et al, 2015), with extremely low numbers, and have slow proliferation in vitro.…”

Isolation of endothelial progenitor cells from human adipose tissue

“…It has been noted in some previous studies that EPCs are detected, and only at low numbers, in umbilical cord blood (Finney et al, 2006;Lin et al, 2011;Moon et al, 2013;Phuc et al, 2012), bone marrow (Ii, 2010) and peripheral blood (Donndorf et al, 2015). These EPCs have been successfully applied to treat ischemia-related diseases, such as hindlimb ischemia (Flex et al, 2016;Yu et al, 2015), stroke (Bai et al, 2015;, diabetic ulcer (Barcelos et al, 2009;Tam et al, 2015), and myocardial infarction (Mehmood et al, 2015;Sheng et al, 2015).…”

“…EPCs have been used effectively to treat hindlimb ischemia (Flex et al, 2016;Yu et al, 2015), stroke (Bai et al, 2015;, diabetic ulcer (Barcelos et al, 2009;Tam et al, 2015), and myocardial infarction (Mehmood et al, 2015;Sheng et al, 2015). However, the greatest limitation of EPC-based transplantation is the scarcity of EPCs; unlike other stem cells, EPCs exist in umbilical cord blood (Finney et al, 2006;Lin et al, 2011;Moon et al, 2013;Phuc et al, 2012), bone marrow (Ii, 2010) and peripheral blood (Donndorf et al, 2015), with extremely low numbers, and have slow proliferation in vitro.…”