Enterovirus 71 Outbreak in the People's Republic of China in 2008

Yang, Fan; Ren, Lili; Xiong, Zhaohui; Li, Jianguo; Xiao, Yan; Zhao, Rong; He, Yaqing; Bu, Ge; Zhou, Suna; Wang, Jianwei; Qi, Jin

doi:10.1128/jcm.00563-09

Cited by 260 publications

(216 citation statements)

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“…The genotype analysis revealed that the EV71 strains of the Nanchang region belonged to the C4 subgenotype, commonly found in China in 2008, and that they varied distinctly from the strains reported by Liu et al in 2011 (11). On the basis of this study, the EV71 strains prevalent in the Nanchang region were found to be genetically similar to the C4 strains of EV71 prevalent in Fuyang, a neighboring city where the HFMD outbreak occurred in 2008 (7). In summary, the present study showed that in 2011, the EV71 C4 virus was the most prevalent causative agent of HFMD in children of the Nanchang region.…”

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confidence: 73%

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Molecular Epidemiology of Human Enterovirus 71 Strains in the Nanchang Region of China in 2011

et al. 2013

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SUMMARY: Hand, foot, and mouth disease (HFMD) is caused by enteroviruses, most commonly enterovirus 71 (EV71) and coxsackievirus A16 (CA16). In general, EV71 infection is more likely to induce severe complications and mortality than other enterovirus infections. The present study focuses on the molecular epidemiology of human EV71 strains in the Nanchang region of China in 2011. Overall, 651 specimens (throat or rectal swabs) were collected, and one-step reverse transcriptase-polymerase chain reaction was performed for analysis. Enteroviruses were detected in 62.2z (405/651) of the specimens. EV71, CA16, and other enteroviruses were found in 292, 73, and 40 specimens, respectively. Phylogenetic analysis of the VP1 region of the 8 EV71 strains found in the Nanchang region indicated that these strains belong to the C4 subgenotype. This study shows that the C4 subgenotype strain of EV71 was prevalent in the HFMD cases of Nanchang in 2011, and it reports the first incidence of adults being infected by EV71 in the Nanchang region. Thus, the surveillance of HFMD epidemiology and monitoring of HFMD severity should be continued.

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confidence: 73%

“…EV71-associated HFMD outbreaks with severe central nervous system complications have frequently been reported, especially in the Asian-Pacific region (5,6). In 2008, an EV71 outbreak in China infected over 25,000 people and caused over 30 deaths (7).…”

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confidence: 99%

Molecular Epidemiology of Human Enterovirus 71 Strains in the Nanchang Region of China in 2011

et al. 2013

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“…[32][33][34] However, there are no available specific treatments for EV71 infections, and so Table 2A. The protection conferred by antisera against lethal eV71 challenge in suckling mice.…”

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confidence: 99%

Characterization of the enterovirus 71 P1 polyprotein expressed inPichia pastoras a candidate vaccine

Han

Ying

Zhou

et al. 2014

Human Vaccines & Immunotherapeutics

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“…EV-A71 outbreaks, most of which had lethal cases, continued in Korea, Singapore, Japan, Malaysia, Vietnam and Thailand [51]. In 2008 there was a large EV-A71 outbreak in China, with almost half a million reported HFMD cases and 122 fatal cases [53]. The virus kept on circulating in China and contributed to HFMD cases with CNS complications and fatalities until at least 2014 [54].…”

Section: Enterovirus 71 and Coxsackievirus A16mentioning

confidence: 99%

Human picornaviruses associated with neurological diseases and their neutralization by antibodies

Anastasina

Domanska

Palm

et al. 2017

Journal of General Virology

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Picornaviruses are the most commonly encountered infectious agents in mankind. They typically cause mild infections of the gastrointestinal or respiratory tract, but sometimes also invade the central nervous system. There, they can cause severe diseases with long-term sequelae and even be lethal. The most infamous picornavirus is poliovirus, for which significant epidemics of poliomyelitis were reported from the end of the nineteenth century. A successful vaccination campaign has brought poliovirus close to eradication, but neurological diseases caused by other picornaviruses have increasingly been reported since the late 1990s. In this review we focus on enterovirus 71, coxsackievirus A16, enterovirus 68 and human parechovirus 3, which have recently drawn attention because of their links to severe neurological diseases. We discuss the clinical relevance of these viruses and the primary role of humoral immunity in controlling them, and summarize current knowledge on the neutralization of such viruses by antibodies.

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Enterovirus 71 Outbreak in the People's Republic of China in 2008

Cited by 260 publications

References 4 publications

Molecular Epidemiology of Human Enterovirus 71 Strains in the Nanchang Region of China in 2011

Molecular Epidemiology of Human Enterovirus 71 Strains in the Nanchang Region of China in 2011

Characterization of the enterovirus 71 P1 polyprotein expressed inPichia pastoras a candidate vaccine

Human picornaviruses associated with neurological diseases and their neutralization by antibodies

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