Enteroviral hepatitis in children

Kawashima, Hisashi; Ryou, Shimizu; Nishimata, Shigeo; Ioi, Hiroaki; Kashiwagi, Yasuyo; Iizumi, Mamoru; Takami, Takeshi; Sasamoto, Masato; Takekuma, Kouji; Hoshika, Akinori; Mōri, Takayuki

doi:10.1046/j.1442-200x.2004.01857.x

Cited by 15 publications

(2 citation statements)

References 19 publications

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“…Coxsackie viral infection in human being has been associated with myocarditis, myopericarditis, aseptic meningitis and chronic autoimmune diseases such as insulin-dependent diabetes mellitus (IDDM) [6][7][8] . A chronic form of the infection in females may lead to new born babies with neonatal myocarditis and/or hepatitis 9,10 . Currently, there is no specific antiviral therapy available for the treatment of infections with this virus 5 .…”

Section: Introductionmentioning

confidence: 99%

In silico development of a novel putative inhibitor of the 3C protease of Coxsackievirus B3 with a benzene sulfonamide skeleton

et al. 2017

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Availability of X-ray crystal structure of 3C protease of several enteroviruses provided an opportunity for in silico drug design and development approach. Presented study is aimed at designing a novel compound targeting 3C protease of Coxsackievirus (CVB3), which is reported frequently to cause myocarditis in North America and Europe. A pthalimido-sulfonamide derivative (ZINC13799063) was identified through high-throughput virtual screening (HTVS) approach from the top HITs. A small library of phalimido-sulphonamides was enumerated to find a potential LEAD. Compound 17 from the library was found to inhibit CVB3 selectively in cell based antiviral assay at a concentration of EC50=1.0±0.1 µM with a selectivity index of >140. Molecular dynamics study was performed to investigate the selective inhibition of CVB3 over CVB4.

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Section: Introductionmentioning

confidence: 99%

In silico development of a novel putative inhibitor of the 3C protease of Coxsackievirus B3 with a benzene sulfonamide skeleton

et al. 2017

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“…The non-polio enteroviruses are responsible for a wide spectrum of disease in humans of all ages. The majority of non-polio enteroviruses infections are asymptomatic [39,41] but in some cases, can lead to severe diseases, such as aseptic meningitis [6], pancreatitis [15,24], hepatitis [9,17,38] and myocarditis [18]. Although the disease spectra of different serotypes overlap considerably, some syndromes are caused by one or a few serotypes [27].…”

Section: Introductionmentioning

confidence: 99%