eNOS gene polymorphisms modify the association of PM10 with oxidative stress

Kim, Jin Hee; Choi, Yu Hyeon; Bae, Sanghyuk; Park, Hye-Yin; Hong, Yun–Chul

doi:10.1016/j.toxlet.2012.09.006

Cited by 19 publications

(18 citation statements)

References 24 publications

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“…24 Studies of O 2 saturation have been inconsistent, 13–15,21 but of those that have detected significant associations with air pollution, they have been small in magnitude, similar to our findings, at lags of 0 or 1 day. 13,14 Previous studies have reported significant increases in MDA 26 and 8-OHdG 27 within days of air pollution exposure, similar to our results for 8-OHdG. Our findings from 2013 of an approximately 1 mm Hg increase in systolic and diastolic blood pressure per IQR increase in AQHI at lag 2 days are also consistent with the magnitude of effect observed in other studies.…”

Section: Discussionsupporting

confidence: 92%

Cardio-Respiratory Effects of Air Pollution in a Panel Study of Outdoor Physical Activity and Health in Rural Older Adults

Stieb

Shutt

Kauri

et al. 2017

Journal of Occupational &Amp; Environmental Medicine

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Objective:To examine cardio-respiratory effects of air pollution in rural older adults exercising outdoors.Methods:Adults 55 and over completed measurements of blood pressure, peak expiratory flow and oximetry daily, and of heart rate variability, endothelial function, spirometry, fraction of exhaled nitric oxide and urinary oxidative stress markers weekly, before and after outdoor exercise, for 10 weeks. Data were analyzed using linear mixed effect models.Results:Pooled estimates combining 2013 (n = 36 participants) and 2014 (n = 41) indicated that an interquartile increase in the air quality health index (AQHI) was associated with a significant (P < 0.05) increase in heart rate (2.1%) and significant decreases in high frequency power (−19.1%), root mean square of successive differences (−9.5%), and reactive hyperemia index (−6.5%).Conclusions:We observed acute subclinical adverse effects of air pollution in rural older adults exercising outdoors.

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Section: Discussionsupporting

confidence: 92%

Cardio-Respiratory Effects of Air Pollution in a Panel Study of Outdoor Physical Activity and Health in Rural Older Adults

Stieb

Shutt

Kauri

et al. 2017

Journal of Occupational &Amp; Environmental Medicine

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“…Therefore, we used creatinine-adjusted urinary cotinine levels in a logistic regression model to adjust for primary and secondhand smoke exposure of participants. Urinary cotinine levels were analysed by an ELISA method 24. Blood pressure was considered as ‘normal’ for participants whose systolic and diastolic blood pressure was below 120 and 80 mm Hg, respectively, and ‘hypertension’ for participants whose systolic and diastolic blood pressure was over 140 or 90 mm Hg, respectively.…”

Section: Methodsmentioning

confidence: 99%

Does cadmium exposure contribute to depressive symptoms in the elderly population?

2016

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“…Urinary MDA levels were determined by measuring thiobarbituric acid reactive substances according to the previously reported procedures [34].…”

Section: Methodsmentioning

confidence: 99%

Diethylhexyl Phthalates Is Associated with Insulin Resistance via Oxidative Stress in the Elderly: A Panel Study

et al. 2013

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BackgroundInsulin resistance (IR) is believed to be the underlying mechanism of metabolic syndrome and type 2 diabetes mellitus (DM). Recently, a few studies have demonstrated that phthalates could cause oxidative stress which would contribute to the development of IR. Therefore, we evaluated whether exposure to phthalates affects IR, and oxidative stress is involved in the phthalates-IR pathway.MethodsWe recruited 560 elderly participants, and obtained blood and urine samples during repeated medical examinations. For the determination of phthalate exposure, we measured urinary levels of mono-(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP) and mono-(2-ethyl-5-oxohexyl) phthalate (MEOHP) as metabolites of diethylhexyl phthalates (DEHP), and mono-n-butyl phthalate (MnBP) as a metabolite of di-butyl phthalate (DBP). Malondialdehyde (MDA), an oxidative stress biomarker, was also measured in urine samples. We measured serum levels of fasting glucose and insulin, and derived the homeostatic model assessment (HOMA) index to assess IR. A mixed-effect model and penalized regression spline were used to estimate the associations among phthalate metabolites, MDA, and IR.ResultsThe molar sum of MEHHP and MEOHP (∑DEHP) were significantly associated with HOMA (β = 0.26, P = 0.040), and the association was apparent among participants with a history of DM (β = 0.88, P = 0.037) and among females (β = 0.30, P = 0.022). However, the relation between MnBP and HOMA was not found. When we evaluated whether oxidative stress is involved in increases of HOMA by ∑DEHP, MDA levels were significantly associated with increases of ∑DEHP (β = 0.11, P<0.001) and HOMA (β = 0.49, P = 0.049).ConclusionsOur study results suggest that exposure to DEHP in the elderly population increases IR, which is related with oxidative stress, and that participants with a history of DM and females are more susceptible to DEHP exposure.

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eNOS gene polymorphisms modify the association of PM10 with oxidative stress

Cited by 19 publications

References 24 publications

Cardio-Respiratory Effects of Air Pollution in a Panel Study of Outdoor Physical Activity and Health in Rural Older Adults

Cardio-Respiratory Effects of Air Pollution in a Panel Study of Outdoor Physical Activity and Health in Rural Older Adults

Does cadmium exposure contribute to depressive symptoms in the elderly population?

Diethylhexyl Phthalates Is Associated with Insulin Resistance via Oxidative Stress in the Elderly: A Panel Study

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