Enhancing the Working Memory of Stroke Patients Using tDCS

Jo, Jung Mi; Kim, Yun-Hee; Ko, Myoung-Hwan; Ohn, Suk Hun; Joen, B; Lee, Kwang Ho

doi:10.1097/phm.0b013e3181a0e4cb

Cited by 204 publications

(125 citation statements)

References 25 publications

(35 reference statements)

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“…Anodal tDCS of the dorsolateral prefrontal cortex (DLPFC) with the cathode placed over the contralateral supraorbital region has been found to improve performance in several cognitive domains, including executive functions, verbal skills, and memory performance in healthy subjects (Iyer et al, 2005;Wassermann and Grafman, 2005;Cerruti and Schlaug, 2009;Sparing et al, 2008;Dockery et al, 2009;Fiori et al, 2011), as well as in patients with Parkinson's disease and stroke Jo et al, 2009). Promising pilot data suggest a positive therapeutic effect in patients with major depression Boggio et al, 2008;Rigonatti et al, 2008;Ferrucci et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Prefrontal Transcranial Direct Current Stimulation Changes Connectivity of Resting-State Networks during fMRI

Keeser¹,

Meindl²,

Bor³

et al. 2011

J. Neurosci.

510

348

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Transcranial direct current stimulation (tDCS) has been proposed for experimental and therapeutic modulation of regional brain function. Specifically, anodal tDCS of the dorsolateral prefrontal cortex (DLPFC) together with cathodal tDCS of the supraorbital region have been associated with improvement of cognition and mood, and have been suggested for the treatment of several neurological and psychiatric disorders. Although modeled mathematically, the distribution, direction, and extent of tDCSmediated effects on brain physiology are not well understood. The current study investigates whether tDCS of the human prefrontal cortex modulates resting-state network (RSN) connectivity measured by functional magnetic resonance imaging (fMRI). Thirteen healthy subjects underwent real and sham tDCS in random order on separate days. tDCS was applied for 20 min at 2 mA with the anode positioned over the left DLPFC and the cathode over the right supraorbital region. Patterns of resting-state brain connectivity were assessed before and after tDCS with 3 T fMRI, and changes were analyzed for relevant networks related to the stimulation-electrode localizations. At baseline, four RSNs were detected, corresponding to the default mode network (DMN), the left and right frontal-parietal networks (FPNs) and the self-referential network. After real tDCS and compared with sham tDCS, significant changes of regional brain connectivity were found for the DMN and the FPNs both close to the primary stimulation site and in connected brain regions. These findings show that prefrontal tDCS modulates resting-state functional connectivity in distinct functional networks of the human brain.

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Section: Introductionmentioning

confidence: 99%

Prefrontal Transcranial Direct Current Stimulation Changes Connectivity of Resting-State Networks during fMRI

Keeser¹,

Meindl²,

Bor³

et al. 2011

J. Neurosci.

510

348

View full text Add to dashboard Cite

show abstract

“…Although the mechanism of tDCS remains an area of active research, there is evidence to suggest that in the cortex tDCS modulates synaptic strength and likely stimulates pyramidal neurons and interneurons (Nitsche et al, 2005;Stagg and Nitsche, 2011). As a therapy, tDCS has shown some success in treating major depression (Fregni et al, 2006a,b;Brunoni et al, 2011), memory deficits in Parkinson's disease (Boggio et al, 2006), memory deficits in Alzheimer's disease (Boggio et al, 2009(Boggio et al, , 2012, aphasia (Baker et al, 2010;Kang et al, 2011;You et al, 2011), and as a recovery aid for stroke patients (Fregni et al, 2005b;Miniussi et al, 2008;Jo et al, 2009;Kang et al, 2009;Bolognini et al, 2011;Bueno et al, 2011). Despite these findings, less research has been done investigating the effects of tDCS on WM.…”

Section: Introductionmentioning

confidence: 99%

Parietal Contributions to Visual Working Memory Depend on Task Difficulty

Jones¹,

Crane²,

Feenstra³

et al. 2012

PsycEXTRA Dataset

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The nature of parietal contributions to working memory (WM) remain poorly understood but of considerable interest. We previously reported that posterior parietal damage selectively impaired WM probed by recognition (Berryhill and Olson, 2008a). Recent studies provided support using a neuromodulatory technique, transcranial direct current stimulation (tDCS) applied to the right parietal cortex (P4). These studies confirmed parietal involvement in WM because parietal tDCS altered WM performance: anodal current tDCS improved performance in a change detection task, and cathodal current tDCS impaired performance on a sequential presentation task. Here, we tested whether these complementary results were due to different degrees of parietal involvement as a function of WM task demands, WM task difficulty, and/or participants' WM capacity. In Experiment 1, we applied cathodal and anodal tDCS to the right parietal cortex and tested participants on both previously used WM tasks. We observed an interaction between tDCS (anodal, cathodal), WM task difficulty, and participants' WM capacity. When the WM task was difficult, parietal stimulation (anodal or cathodal) improved WM performance selectively in participants with high WM capacity. In the low WM capacity group, parietal stimulation (anodal or cathodal) impaired WM performance. These nearly equal and opposite effects were only observed when the WM task was challenging, as in the change detection task. Experiment 2 probed the interplay of WM task difficulty and WM capacity in a parametric manner by varying set size in the WM change detection task. Here, the effect of parietal stimulation (anodal or cathodal) on the high WM capacity group followed a linear function as WM task difficulty increased with set size. The low WM capacity participants were largely unaffected by tDCS. These findings provide evidence that parietal involvement in WM performance depends on both WM capacity and WM task demands. We discuss these findings in terms of alternative WM strategies employed by low and high WM capacity individuals. We speculate that low WM capacity individuals do not recruit the posterior parietal lobe for WM tasks as efficiently as high WM capacity individuals. Consequently, tDCS provides greater benefit to individuals with high WM capacity.

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“…In stroke patients, and using the same montage, improvements in accuracy on n-back and the GoNoGo test were noted [76,77]. A single study [78] tried to assess tDCS in frontotemporal dementia patients and did not find any benefit on verbal fluency.…”

Section: Findings In Healthy Subjects and Patientsmentioning

confidence: 99%

Transcranial Direct Current Stimulation (tDCS): Modulation of Executive Function in Health and Disease

Sarkis

Kaur

Camprodon

2014

Curr Behav Neurosci Rep

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Transcranial direct current stimulation (tDCS) is a noninvasive method of neuromodulation used in human basic and clinical neuroscience. In this article we review its use in the cognitive neurosciences to study executive function, and current preliminary explorations of its therapeutic value as a cognitive enhancer for patients with compromised dysexecutive symptoms. We discuss published studies analyzing their methodology and results. A number of experiments describe improvement in experimental measures of inhibitory control, working memory, and verbal fluency with anodal stimulation over the dorsolateral prefrontal cortex. Positive findings are also described in different clinical populations. Despite the growing promise and interest in tDCS given its safety, simplicity, and low cost, findings are not always consistent across studies due to a host of variables we discuss (study design, stimulation parameters, neuroanatomy, genetics, etc.), highlighting the need for a better mechanistic understanding of the effects of tDCS.

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Enhancing the Working Memory of Stroke Patients Using tDCS

Abstract: Our results demonstrated that anodal transcranial direct current stimulation over the left dorsolateral prefrontal cortex was associated with enhanced working memory performance as indexed by the recognition accuracy in patients after a stroke.

Cited by 204 publications

References 25 publications

Prefrontal Transcranial Direct Current Stimulation Changes Connectivity of Resting-State Networks during fMRI

Prefrontal Transcranial Direct Current Stimulation Changes Connectivity of Resting-State Networks during fMRI

Parietal Contributions to Visual Working Memory Depend on Task Difficulty

Transcranial Direct Current Stimulation (tDCS): Modulation of Executive Function in Health and Disease

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