Abstract:Transcranial direct current stimulation (tDCS) has been proposed for experimental and therapeutic modulation of regional brain function. Specifically, anodal tDCS of the dorsolateral prefrontal cortex (DLPFC) together with cathodal tDCS of the supraorbital region have been associated with improvement of cognition and mood, and have been suggested for the treatment of several neurological and psychiatric disorders. Although modeled mathematically, the distribution, direction, and extent of tDCSmediated effects … Show more
“…When the left DLPFC was stimulated with anodal tDCS, and the right supraorbital region received cathodal tDCS, resting-state fMRI showed changes in connectivity within both the default-mode network and fronto-parietal networks (Keeser et al, 2011). A c c e p t e d M a n u s c r i p t Sale et al,21 5.…”
Section: Changing the Functional Interplay Between Multiple Networkmentioning
Please cite this article as: Sale, M.V., Mattingley, J.B., Zalesky, A., Cocchi, L.,Imaging human brain networks to improve the clinical efficacy of noninvasive brain stimulation, Neuroscience and Biobehavioral Reviews (2015), http://dx
“…When the left DLPFC was stimulated with anodal tDCS, and the right supraorbital region received cathodal tDCS, resting-state fMRI showed changes in connectivity within both the default-mode network and fronto-parietal networks (Keeser et al, 2011). A c c e p t e d M a n u s c r i p t Sale et al,21 5.…”
Section: Changing the Functional Interplay Between Multiple Networkmentioning
Please cite this article as: Sale, M.V., Mattingley, J.B., Zalesky, A., Cocchi, L.,Imaging human brain networks to improve the clinical efficacy of noninvasive brain stimulation, Neuroscience and Biobehavioral Reviews (2015), http://dx
“…This biological technique induces small changes (<1mV) in the membrane potential (Datta et al, 2009), acting in the frequency of spike timing and modifying net cortical excitability (Purpura & McMurtry, 1965), which can increase cortical perfusion and functional activity (Keeser et al, 2011). Anodal stimulation is found to increase cortical excitability, whereas cathodal stimulation is found to decrease excitability.…”
Rumination is a cognitive-affective thinking style that plays a key role in the onset and maintenance of depression. Recently, it was shown that clinically depressed patients who received a neurocognitive training -involving two weeks of repetitive cognitive control exercises that necessitate prefrontal engagement -are more able to control over ruminative negative thoughts than patients who only received treatment as usual. Transcranial Direct Current Stimulation (tDCS) is a biological technique that can directly modulate prefrontal excitability via the manipulation of neural membrane potentials. In this randomized double-blind trial, we investigated whether bifrontal tDCS (anode over the left/cathode over the right dorsolateral prefrontal cortex (DLPFC)) would enhance the influence of a neurocognitive training on depressive brooding, the maladaptive form of rumination. Major depressed patients were trained using a procedure based on the Paced Auditory Serial Addition Task (PASAT), a task that relies heavily on working memory and is found to engage the DLPFC. One group (n=19) completed the PASAT training together with active tDCS and another group (n=14) completed the same training together with sham (placebo) tDCS. In both groups, depressive brooding was reduced following the PASAT training. Moreover, we observed that improvement in working memory over the course of the training was associated with a greater reduction in depressive brooding post versus pre intervention. However, tDCS did not moderate this association between changes in working memory and changes in depressive brooding. Possible explanations for this absent moderation of tDCS, as well as avenues for future research to influence ruminative thinking in depression, are discussed.
“…Une ré cente é tude de neuroimagerie a mis en é vidence l'effet d'une stimulation pré frontale sur la connectivité neuronale grâ ce à l'IRMf. Cette technique a montré une modulation de la connectivité du ré seau du mode par dé faut et des ré seaux fronto-parié taux bilaté ralement à la suite d'une stimulation du cortex PFDL gauche (Keeser et al, 2011). Cette é tude met en é vidence les mé canismes sous-jacents de la tDCS qui pourraient expliquer, en partie, les effets cognitifs de la stimulation.…”
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