Enhancing the Immunogenicity of Liposomal Hepatitis B Surface Antigen (HBsAg) By Controlling Its Delivery From polymeric Microspheres

Machluf, Marcelle; Apte, Ron N.; Regev, Oren; Cohen, Smadar

doi:10.1002/1520-6017(200012)89:12<1550::aid-jps5>3.0.co;2-z

Cited by 19 publications

(9 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…*Corresponding author. Department of Chemical and Environmental Engineering, Faculty of Engineering, National University of Singapore, 10 systems, in which drugs are incorporated into, or attached to, the polymer or lipid [3]. Since polymer molecules are normally much larger than those of lipids, the former frequently form solid phase such as polymeric microspheres or nanoparticles, films, pellets, and the latter usually form liquid or liquid crystalline phase such as phospholipid vesicles (liposomes), cubersones, micelles and other emulsions.…”

Section: Article In Pressmentioning

confidence: 99%

“…A few research groups have reported the encapsulation of liposomes into microspheres made of hydrophilic polymers, such as dextran [9] and alginate-poly(l-lysine) [10]. However, most of the biodegradable polymers approved by the US Food and Drug Administration (FDA), such as poly(lactide-co-glycolide) (PLGA), are hydrophobic.…”

Section: Article In Pressmentioning

confidence: 99%

“…It is interesting to compare the release kinetics with that of the other similar delivery systems mentioned earlier [9,10,13]. In the system of [13], which involved encapsulating alginate microcores into PLA-PEG-PLA microspheres, the microcores were not released out, presumably because the polymer microcores may lack of flow ability.…”

Section: Article In Pressmentioning

confidence: 99%

“…In the system of [13], which involved encapsulating alginate microcores into PLA-PEG-PLA microspheres, the microcores were not released out, presumably because the polymer microcores may lack of flow ability. In contrast, in the systems made of hydrophilic polymers, the liposomes were shown to be released from the polymer matrix [9,10]. The system made of dextran showed an initial off-release [9].…”

Section: Article In Pressmentioning

confidence: 99%

See 3 more Smart Citations

Fabrication and characterizations of a novel drug delivery device liposomes-in-microsphere (LIM)

Feng

Ruan

2004

Biomaterials

View full text Add to dashboard Cite

Section: Article In Pressmentioning

confidence: 99%

Section: Article In Pressmentioning

confidence: 99%

Section: Article In Pressmentioning

confidence: 99%

Section: Article In Pressmentioning

confidence: 99%

See 2 more Smart Citations

Fabrication and characterizations of a novel drug delivery device liposomes-in-microsphere (LIM)

Feng

Ruan

2004

Biomaterials

View full text Add to dashboard Cite

“…It seems that the coating acts as a barrier to microbial contamination, and thus improves survival prospects of the coated cells [40]. In another study, the coating is performed to protect donor mammalian cells against antibodies and cytotoxic cells of the host immune system, allowing the transplantation of cells in the absence of immunosuppression [27,[41][42][43].…”

Section: Various Routes For Vaccine Deliverymentioning

confidence: 99%

Novel antigen delivery technologies: a review

Jain

Singh

2011

Drug Deliv. and Transl. Res.

View full text Add to dashboard Cite

Over the past few years, new insights into immunobiology and delivery systems have allowed the development of better vaccines and for a wider range of diseases. Currently available vaccines represent outstanding success story in modern medicine and have had a dramatic effect on morbidity and mortality worldwide. Conventional vaccines have been based on live attenuated, or killed, viruses or bacteria, or recombinant proteins from these organisms. The design of live attenuated vaccines depended to some extent on serendipity and resulted in low success rates. Both live attenuated and killed vaccines require handling of live pathogens and are associated with safety problems. Despite the success of vaccines, there is a clear need for novel antigen delivery technologies to improve vaccine efficacy and safety. Antigen stability, safety, and immunogenicity are the key hurdles in development of novel antigen delivery technologies. Nowadays, various novel drug delivery systems are becoming one of the fastest growing sectors in the pharmaceutical and biotechnological industries. Delivery of vaccines via oral, intranasal, transcutaneous, and intradermal routes will decrease the risk of needle-borne diseases and may eliminate the need for trained personnel and sterile equipment. Currently, various techniques involving DNA vaccines, adjuvants, nanoparticles, liposome, microneedle, and NanoMAP technology are being developed and evaluated. This review focuses on the current development of some novel vaccine delivery systems and will explore the non-parenteral routes of vaccine administrations.

show abstract

Controlled‐Release Systems for Biologics

Oak¹,

Mandke²,

Layek³

et al. 2013

Pharmaceutical Sciences Encyclopedia

View full text Add to dashboard Cite

It is evident by the progress in new drug delivery technologies that much attention has been devoted toward the way in which biologics are delivered. As shown in this chapter, present efforts in the field of delivery of biologics have accelerated and widened the possibility of their use with therapeutic agents for treatment of various chronic disorders. From the times when achieving a zero‐order release profile was just an imaginary concept and controlled release technology was known only to a few scientists, it has now been established widely and has gained significant applications in variety of fields ranging from gene therapy to tissue engineering.

show abstract

Enhancing the Immunogenicity of Liposomal Hepatitis B Surface Antigen (HBsAg) By Controlling Its Delivery From polymeric Microspheres

Cited by 19 publications

References 17 publications

Fabrication and characterizations of a novel drug delivery device liposomes-in-microsphere (LIM)

Fabrication and characterizations of a novel drug delivery device liposomes-in-microsphere (LIM)

Novel antigen delivery technologies: a review

Controlled‐Release Systems for Biologics

Contact Info

Product

Resources

About