Fabrication and characterizations of a novel drug delivery device liposomes-in-microsphere (LIM)

Feng, Si‐Shen; Ruan, Gang; Li, Qiu-Tian

doi:10.1016/j.biomaterials.2003.12.013

Cited by 75 publications

(44 citation statements)

References 23 publications

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“…While burst releases are useful in dermal and systemic delivery, they may lead to a significant and unpredictable toxicity especially for potent drugs and treatments of chronic diseases. Several strategies have been proposed and controlled release can be achieved by bi-association of liposomes encapsulated inside a polymeric particle [92] as well as chitosan associated with alginate which demonstrate a controlled release and prevention of burst release [93]. Similar strategies can be achieved by using microparticles containing nanoparticles [91].…”

Section: Surface Functionalization Controlledmentioning

confidence: 99%

Recent Advances in Drug Delivery Systems

Martinho¹,

Damgé²,

Reis³

2011

JBNB

166

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Section: Surface Functionalization Controlledmentioning

confidence: 99%

Recent Advances in Drug Delivery Systems

Martinho¹,

Damgé²,

Reis³

2011

JBNB

166

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“…Diversos trabalhos comprovaram o aumento da efi cácia e a redução da toxicidade de substâncias bioativas de origem natural ou sintética, administrados em lipossomas (Ratner, 2002), sistemas nanoparticulados (Feng et al, 2004;Berkland et al, 2002) ou micropartículas (Gupte;Ciftci, 2004;Ribeiro-Costa et al, 2004). Relatos recentes demonstram a atividade antitumoral do taxol (Gupte;Ciftci, 2004) e do ácido úsnico (Cladonia substellata) em microesferas (Ribeiro-Costa et al, 2004), da lectina de Cratylia mollis encapsulada em lipossomas (Andrade et al, 2004), de xantonas (Teixeira et al, 2005), da doxorrubicina em nanopartículas (Barraud et al, 2005) e 5-fl uorouracil em lipossomas (Jin et al, 2005), atividade antiparasitária do praziquantel em lipossomas (Mourão et al, 2005), atividade antibiótica da vancomicina em micropartículas (Le Ray et al, 2005) e anfotericina B em lipossomas (Bellocchio et al, 2005), atividade hipoglicemiante da insulina em micropartículas (Kim et al, 2005) e anti-estrógenos em lipossomas e nanopartículas para tratamento do câncer de mama (Maillard et al, 2005;Memisoglu-Bilensoy et al, 2005).…”

Section: Toxicidade E Viabilização Da Biodisponibilização Da Dctnunclassified

Uma revisão das atividades biológicas da trans-desidrocrotonina, um produto natural obtido de Croton cajucara

Costa¹,

Magalhães²,

Gomes³

et al. 2007

Rev. bras. farmacogn.

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RESUMO:Croton cajucara Beth (Euphorbiaceae) uma espécie medicinal nativa da região Amazônica do Brasil, onde é vulgarmente conhecida como 'sacaca', representa um recurso terapêutico efi caz no tratamento e cura de várias doenças. O metabólito majoritário transdesidrocrotonina (DCTN), isolado das cascas do caule desta planta, encontra-se correlacionado com grande parte das propriedades medicinais da sacaca. Este artigo de revisão, descreve os resultados fi toquímicos e farmacológicos que foram realizados com o diterpeno do tipo clerodano DCTN, bem como seus derivados semi-sintéticos. Adicionalmente, apresenta perspectivas para a biodisponibilização deste protótipo de fármaco em nanosistemas. Unitermos:Croton cajucara, trans-desidrocrotonina, DCTN, fi toquímica, atividade biológica, nanobiotecnologia.ABSTRACT: "A review of the biologic activities of trans-dehydrocrotonin, a natural product obtained from Croton cajucara". Croton cajucara Beth (Euphorbiaceae) is a plant found in the Amazonian Region of North Brazil, where it is popularly known as sacaca. The major secondary metabolite, trans-dehydrocrotonin (DCTN) a clerodane-type diterpene, isolated from the stem bark is a chief bioactive compound of Croton cajucara. This review describes results of extensive pharmacological studies of DCTN, as well as its semi-synthetic derivatives, and also presents insights into the use of DCTN as a therapeutic agent and some potential advantages of its incorporation in drug delivery systems.

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“…Active and passive targeting of liposomes are extensively utilized for the enhanced permeability and retention (EPR) effect and ligand conjugation. [3][4][5] Thermosensitive liposomes are commonly used as drug carriers, and function through externally thermo-stimulated content release. Photosensitive liposomes are commonly triggered to release loaded drugs after reaching a lower critical solution temperature.…”

Section: Introductionmentioning

confidence: 99%

Lipid-coated gold nanocomposites for enhanced cancer therapy

An¹,

Kang²,

Ko³

2015

IJN

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The aim of the work reported here was to develop lipid-coated multifunctional nanocomposites composed of drugs and nanoparticles for use in cancer therapy. We incorporated thermosensitive phospholipids onto the surface of anisotropic gold nanoparticles (AuNPs) to further enhance drug delivery, with possible additional applications for in vivo imaging and photothermal cancer therapy. Lipid-coated nanohybrids loaded with the drug docetaxel (DTX) were prepared by a thin-film formation, hydration, and sonication method. Nanoparticles and their composites were characterized using particle-size analysis, zeta potential measurements, transmission electron microscopy, UV-visible spectroscopy, and reverse-phase high-performance liquid chromatography, demonstrating successful loading of DTX into the lipid bilayer on the surface of the gold nanoparticles. Initial in vitro studies using breast-cancer (MCF-7) and melanoma (B16F10) cell lines demonstrated that the drug-containing nanocomposites at equivalent drug concentrations caused significant cytotoxicity compared to free DTX. Differential flow cytometry analysis confirmed the improved cellular uptake of lipid-coated nanocomposites. Our preliminary results show that DTX-loaded anionic lipid-coated gold nanorod (AL_AuNR_DTX) and cationic lipid-coated gold nanoparticle (CL_AuNP_DTX) possess effective tumor cell-suppression abilities and can therefore be considered promising chemotherapeutic agents. Further evaluation of the therapeutic efficacy of these hybrid nanoparticles combined with external near-infrared photothermal treatment is warranted to assess their synergistic anticancer actions and potential bioimaging applications.

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Fabrication and characterizations of a novel drug delivery device liposomes-in-microsphere (LIM)

Cited by 75 publications

References 23 publications

Recent Advances in Drug Delivery Systems

Recent Advances in Drug Delivery Systems

Uma revisão das atividades biológicas da trans-desidrocrotonina, um produto natural obtido de Croton cajucara

Lipid-coated gold nanocomposites for enhanced cancer therapy

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