Enhancing osteogenesis of adipose-derived mesenchymal stem cells using gold nanostructure/peptide-nanopatterned graphene oxide

Kang, Ee-Seul; Kim, Huijung; Han, Yoojoong; Cho, Yeon‐Woo; Son, Hyungbin; Luo, Zhengtang; Kim, Tae-Hyung

doi:10.1016/j.colsurfb.2021.111807

Cited by 11 publications

(4 citation statements)

References 71 publications

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“…To generate a gold-coated surface grafted with peptides, the gold-coated surface is immersed in aqueous alkanethiol solutions, which can be conjugated with bioactive peptides to generate SAMs, 91,[224][225][226][227][228] or the gold-coated surface is immersed with aqueous cysteine-containing peptide solution. 1,[229][230][231] 3.2.3.2. Carbodiimide reaction.…”

Section: Specific Reaction Between Functional Groups Of Materials Sur...mentioning

confidence: 99%

Cell-binding peptides on the material surface guide stem cell fate of adhesion, proliferation and differentiation

et al. 2023

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Section: Specific Reaction Between Functional Groups Of Materials Sur...mentioning

confidence: 99%

Cell-binding peptides on the material surface guide stem cell fate of adhesion, proliferation and differentiation

et al. 2023

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“…Moreover, CNPs can be synthesised into specific 3D structures, such as CNTs, and sheet forms, such as graphene. In addition, CNPs are biocompatible and can improve cellular functions, for example, cell adhesion and proliferation, making them suitable for stem cell cultivation platforms [94][95][96][97][98][99][100][101][102][103].…”

Section: Carbon Nanomaterial-based Electrochemical Sensorsmentioning

confidence: 99%

Progress in Nano-Biosensors for Non-Invasive Monitoring of Stem Cell Differentiation

2023

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Non-invasive, non-destructive, and label-free sensing techniques are required to monitor real-time stem cell differentiation. However, conventional analysis methods, such as immunocytochemistry, polymerase chain reaction, and Western blot, involve invasive processes and are complicated and time-consuming. Unlike traditional cellular sensing methods, electrochemical and optical sensing techniques allow non-invasive qualitative identification of cellular phenotypes and quantitative analysis of stem cell differentiation. In addition, various nano- and micromaterials with cell-friendly properties can greatly improve the performance of existing sensors. This review focuses on nano- and micromaterials that have been reported to improve sensing capabilities, including sensitivity and selectivity, of biosensors towards target analytes associated with specific stem cell differentiation. The information presented aims to motivate further research into nano-and micromaterials with advantageous properties for developing or improving existing nano-biosensors to achieve the practical evaluation of stem cell differentiation and efficient stem cell-based therapies.

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“…rGO is also commonly used as a coating. Recently, Kang and coworkers [ 47 ] reported that a uniform coating of titanium surfaces with rGO allowed a significant increase of MSC proliferation after only 7 days and promoted the early expression of differentiation markers. The osteoconductive abilities of graphene derivatives have been confirmed not only in in vitro studies but also in vivo.…”

Section: Osteoconductive Properties Of Graphenementioning

confidence: 99%

Graphene-Oxide-Enriched Biomaterials: A Focus on Osteo and Chondroinductive Properties and Immunomodulation

et al. 2022

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Due to its exceptional physical properties, such as high electronic conductivity, good thermal stability, excellent mechanical strength, and chemical versatility, graphene has sparked a lot of interest in the scientific community for various applications. It has therefore been employed as an antibacterial agent, in photothermal therapy (PTT) and biosensors, in gene delivery systems, and in tissue engineering for regenerative purposes. Since it was first discovered in 1947, different graphene derivatives have been synthetized from pristine graphene. The most adaptable derivate is graphene oxide (GO). Owing to different functional groups, the amphiphilic structure of GO can interact with cells and exogenous or endogenous growth/differentiation factors, allowing cell adhesion, growth, and differentiation. When GO is used as a coating for scaffolds and nanomaterials, it has been found to enhance bone, chondrogenic, cardiac, neuronal, and skin regeneration. This review focuses on the applications of graphene-based materials, in particular GO, as a coating for scaffolds in bone and chondrogenic tissue engineering and summarizes the most recent findings. Moreover, novel developments on the immunomodulatory properties of GO are reported.

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Enhancing osteogenesis of adipose-derived mesenchymal stem cells using gold nanostructure/peptide-nanopatterned graphene oxide

Cited by 11 publications

References 71 publications

Cell-binding peptides on the material surface guide stem cell fate of adhesion, proliferation and differentiation

Cell-binding peptides on the material surface guide stem cell fate of adhesion, proliferation and differentiation

Progress in Nano-Biosensors for Non-Invasive Monitoring of Stem Cell Differentiation

Graphene-Oxide-Enriched Biomaterials: A Focus on Osteo and Chondroinductive Properties and Immunomodulation

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