Enhancement of transport of curcumin to brain in mice by poly(n-butylcyanoacrylate) nanoparticle

Sun, Min; Gao, Yan; Guo, Chenyu; Cao, Fuyang; Song, Zhen; Xi, Yang; Yu, Aibing; Li, Aiguo; Zhai, Guangxi

doi:10.1007/s11051-010-9907-4

Cited by 81 publications

(53 citation statements)

References 48 publications

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“…Folate conjugated curcuminloaded human serum albumin nanoparticles are reported to impart sustained curcumin release at desired sites and prolonged retention time in vivo [28]. Curcumin encapsulation in a cationic liposome containing PEI-PEG as a carrier exhibited enhanced anti-tumor effects with increased anti-proliferative effects due to rapid penetration of encapsulated curcumin into the cells [29]. In line curcumin loaded lipid nanoparticles inhibited cellular proliferation, migration, incursion, cell cycle progression and contributed to higher percentage of apoptosis in glioma cells demonstrating superiority of nanoparticle encapsulated curcumin in aqueous solubility, cellular uptake, controlled release and dissolution rates [30].…”

Section: Discussionmentioning

confidence: 99%

Hepato therapeutic Efficacy of Native Curcumim and Nano –curcumin : A Novel Therapy Against Hyperthyroidism Induced Liver Oxidative and Inflammatory Damage in Rats

Al-Bishri¹

2017

Int. J. Adv. Res. Biol. Sci.

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Recent works have indicated the beneficial efficacy of using nanocurcumin in addressing poor bioavailability commonly associated with native curcumin. Curcumin has been shown to alleviate hyperthyroidism induced liver dysfunction. Here we carried out a comparative study using both native curcumin and nanocurcumin to verify the superior effects of encapsulation of curcumin in nanomaterials in blunting liver dysfunction in L-thyroxine induced hyperthyroid rats. Native curcumin (NC) and poly (lactide-co-glycolic acid (PLGA) encapsulated curcumin (PNC) significantly increased liver catalase activity and reduced glutathione (GSH) levels and significantly declined malondialdehyde (MDA) levels in hyperthyroid rats. However, rats treated with PNC had significantly better ameliorative effects on these parameters than rats treated with NC. Similarly, PNC showed significantly improved effects in lowering inflammatory mediators including TNF-a, IL-6, VEGF, CRP and caspase protein levels compared to NC in hyperthyroid rats. Serum T3, T4, and TSH levels and liver functional markers including albumin, ALT, ASP and AST were better controlled in PNC treated rats than in NC treated hyperthyroid rats. DNA fragmentation as estimated by comet assay was significantly lower in PNC treated rats than in NC treated rats. Likewise, significantly fewer histopathological and ultrastructural changes were observed in liver tissue in PNC treated hyperthyroid rats. Conclusion: Our work illustrates the capability of PNC to resolve hyperthyroidism induced liver dysfunction and substantiate the findings that beneficial effects of curcumin may be maximized by improving its stability and bioavailability by its encapsulation in nanoparticles.

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Section: Discussionmentioning

confidence: 99%

Hepato therapeutic Efficacy of Native Curcumim and Nano –curcumin : A Novel Therapy Against Hyperthyroidism Induced Liver Oxidative and Inflammatory Damage in Rats

Al-Bishri¹

2017

Int. J. Adv. Res. Biol. Sci.

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“…For comparison, Fig. 3b displays also the release of pure curcumin [50]. It is approximately 91% within 6 h indicating that the release of Cur from solution through the dialysis membrane is a fast process.…”

Section: Kinetics Of the Curcumin Releasementioning

confidence: 99%

Direct chemical grafted curcumin on halloysite nanotubes as dual-responsive prodrug for pharmacological applications

Massaro

Amorati

Cavallaro

et al. 2016

Colloids and Surfaces B: Biointerfaces

145

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“…The coating of P-80 on the surface QT-PBCA helps in keeping the formulation in the circulation for a prolonged period. 17,20 The area under the concentration-time curve (AUC total ) of QT-PBCA NPs was 248.63±6.82 μg⋅h/mL; for QT-PBCA+P-80, it was 313.97±7.88 μg⋅h/mL. The areas were ~2.4-and 4.1-fold …”

Section: In Vivo Pharmacokinetics and Biodistribution Studies In Wistmentioning

confidence: 99%

“…16 A recent study has shown that PBCA NPs have been widely investigated to enhance the oral absorption of poorly soluble polyphenols and isoflavones such as curcumin and puerarin. 17,18 Most interestingly, PBCA NPs have been employed as effective delivery systems in the brain because the particles entrap the compounds and prevent rapid elimination or degradation as well as promote penetration through the BBB and distribution in the brain tissue when coated with polysorbate-80 (P-80) on their surfaces. 19 There have been several reports of PBCA NPs coated with P-80 that could significantly improve the delivery to the brain of anticancer agents, 20 antifungal drugs, 21 peptides, 22 MRZ 2/576 (N-methyl-d-aspartate receptor antagonists), 23 antibiotics, 24 nonsteroidal anti-inflammatory drugs, 25 and antiviral drugs.…”

Section: Introductionmentioning

confidence: 99%

“…Previous reports show that P-80, coated with PBCA NPs that mimic low-density lipoprotein, may absorb apolipoproteins such as apolipoproteins B and E or apolipoproteins A-I and IV after being injected into the blood stream. 17,19,22 As far as the mechanism is concerned, receptor-mediated endocytosis P-80 acts mainly as an anchor for apolipoprotein-overcoated NPs. QT-PBCA would mimic the lipoprotein particles and interact with the brain capillary endothelial cells and later be taken up by the same endothelial system.…”

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confidence: 99%

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Poly(n-butylcyanoacrylate) nanoparticles for oral delivery of quercetin: preparation, characterization, and pharmacokinetics and biodistribution studies in Wistar rats

Bagad¹,

Khan²

2015

IJN

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Background Quercetin (QT) is a potential bioflavonol and antioxidant with poor bioavailability and very low distribution in the brain. A new oral delivery system comprising of poly(n-butylcyanoacrylate) nanoparticles (PBCA NPs) was introduced to improve the oral bioavailability of QT and to increase its distribution in the brain. Physicochemical characteristics, in vitro release, stability in simulated gastric fluid and intestinal fluids, and pharmacokinetics and biodistribution studies of QT-PBCA NPs coated with polysorbate-80 (P-80) were investigated. Objective This study aimed to investigate the physicochemical characteristics, in vitro release, stability in simulated gastric fluid and intestinal fluids, and pharmacokinetics and biodistribution studies of QT-PBCA NPs coated with polysorbate-80 (P-80). Results The results showed that QT-PBCA NPs and QT-PBCA NPs coated with P-80 (QT-PBCA+P-80) had mean particle sizes of 161.1±0.44 nm and 166.6±0.33 nm respectively, and appeared spherical in shape under transmission electron microscopy. The mean entrapment efficiency was 79.86%±0.45% for QT-PBCA NPs and 74.58%±1.44% for QT-PBCA+P-80. The in vitro release of QT-PBCA NPs and QT-PBCA+P-80 showed an initial burst release followed by a sustained release when compared to free QT. The relative bioavailability of QT-PBCA NPs and QT-PBCA+P-80 enhanced QT bioavailability by 2.38- and 4.93-fold respectively, when compared to free QT. The biodistribution study in rats showed that a higher concentration of QT was detected in the brain after the NPs were coated with P-80. Conclusion This study indicates that PBCA NPs coated with P-80 can be potential drug carriers for poorly water-soluble drugs. These NPs were observed to improve the drugs’ oral bioavailability and enhance their transport to the brain.

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Enhancement of transport of curcumin to brain in mice by poly(n-butylcyanoacrylate) nanoparticle

Cited by 81 publications

References 48 publications

Hepato therapeutic Efficacy of Native Curcumim and Nano –curcumin : A Novel Therapy Against Hyperthyroidism Induced Liver Oxidative and Inflammatory Damage in Rats

Hepato therapeutic Efficacy of Native Curcumim and Nano –curcumin : A Novel Therapy Against Hyperthyroidism Induced Liver Oxidative and Inflammatory Damage in Rats

Direct chemical grafted curcumin on halloysite nanotubes as dual-responsive prodrug for pharmacological applications

Poly(n-butylcyanoacrylate) nanoparticles for oral delivery of quercetin: preparation, characterization, and pharmacokinetics and biodistribution studies in Wistar rats

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