Enhancement of solubility of poorly water soluble anti hypertensive drug by nanosizing approach

Abstract

The objective of this research study was to optimize formulation and process variables affecting characteristic of nanosuspension in bead milling process. In this study, the practically water-insoluble telmisartan was nanoground by using top down method i.e. media milling method. Here the media used is ZnO2 beads. A variety of surface active agents were tested for their stabilizing effects. Formulation factors evaluated were ratio of polymer to drug, whereas process parameters were milling time and concentration of ZnO2 beads. Different concentration of stabilizers such as poloxamer 188, poloxamer 407, HPMC E 15, PVP K30 and combination of stabilizers were used for preparation of telmisartan nanosuspension. Responses measured in this study include particle size measurement, particle size distribution and zeta potential.

Carboxymethyl Chitosan Modified Carbon Nanoparticle for Controlled Emamectin Benzoate Delivery: Improved Solubility, pH-Responsive Release, and Sustainable Pest Control

“…The nanoscale EB@ CMC@CNP contributes greatly to its solubility in aqueous solution, because the ultrasmall size is beneficial to improve the solubility of hydrophobic matter. 45,46 The hydrate particle size of EB@CMC@CNP is 28.21 nm, as shown in Figure 1c. The value is larger than that obtained from TEM, because of the hydration effect of nanoparticles in aqueous solution, as the Wang group has reported.…”

Co-crystallization: a green approach for the solubility enhancement of poorly soluble drugs

“…Most commonly, micelles, nanoemulsions, liposomes, carbon nanotubes, solid lipid nanoparticles, dendrimers, polymeric nanoparticles, and so on are explored that can further sustain, target, and control drug delivery. 32,33 Nanotechnology versions of various drugs, like nitrendipine, 34 griseofulvin (), 35 carvedilol, 36 nifedipine, 37 and valsartan, 38 are reported in the literature to enhance the dissolution rate and solubility.…”

Development of Stable Nanosuspension Loaded Oral Films of Glimepiride With Improved Bioavailability

“…[21,22]. Therefore it can be said that formulating nanosuspensions of glimepiride by simple high shear homogenization method using hydrophilic polymer HPMC E-15 which acts as a steric stabilizer could enhance dissolution rate significantly [23] The increase in dissolution profile of GNS2 may be due to an increase in the stirring times during preparation as compared to their respective nanosuspension formulations, which resulted in smaller particle sizes. As the size decreases, the effective increase in particle surface area results in an increase in dissolution velocity according to the Nernst Brunner-Noyes Whitney equation [24].…”