Development of Stable Nanosuspension Loaded Oral Films of Glimepiride With Improved Bioavailability

Kilor, Vaishali; Sapkal, Nidhi; Daud, Anwar; Humne, Shruti; Gupta, Tushar

doi:10.22159/ijap.2017v9i2.16714

Cited by 18 publications

(12 citation statements)

References 21 publications

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“…Later on 1990, the buccal film were considered to be more preferable over other adhesive dosage forms like tablets, capsules etc. as these polymeric buccal films have better flexibility and comfort related properties [105]. In addition to these properties, buccal polymeric films can show comparatively better residence time on the mucosa as compared to other dosage forms which can be easily diluted and easily washed away and can be removed from the buccal cavity by saliva.…”

Section: Polymeric Filmsmentioning

confidence: 99%

Overview of Mucoadhesive Biopolymers for Buccal Drug Delivery Systems

et al. 2019

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Mucoadhesive dosage forms may be intended for facilitation of prolonged retention time at the application site hence providing drug release in a controlled rate for enhanced improvement of therapeutic activity and its outcome. The buccal mucosa has been investigated for systemic drug delivery and local drug treatment or therapy that is subjected to first pass metabolism. The applicability of bio-adhesion approach in buccal drug delivery proved great therapeutic potential to overcome the limitation of conventional buccal drug delivery. The delivery via buccal route using mucoadhesive biopolymers such as various natural gums e.g. carrageenans, gum karaya, gum arabic, locust bean gum, khaya gum, gum ghatti, albizia gum, guar gum, starch, cellulose, larch gum and pectin etc. and various thiolated and carboxymethylated polymers has been the subject of interest since the early 20th century. The present article is focused mainly on the oral mucosa, mechanism of drug permeation, and characteristics of the desired polymers, the manuscript then proceeds to cover the theories behind the adhesion of bioadhesive polymers to the mucosal epithelium followed by the factors affecting mucoadhesion. Further the author has also discussed on the new generation of mucoadhesive polymers and their properties, recent mucoadhesive formulations for enhanced buccal drug delivery, various marketed products and patent literature. Various online search engines and scientific journals were employed for the collection of literature and scientific data and information related to the topic using keywords like mucoadhesive polymers, buccal drug delivery, buccal patches, tablets, films, gels, powder from the year 2002 and above.

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Section: Polymeric Filmsmentioning

confidence: 99%

Overview of Mucoadhesive Biopolymers for Buccal Drug Delivery Systems

et al. 2019

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“…Nanosuspension containing model drug tadalafil were prepared using high shear homogenization technique [15]. HPMC E 15 and SDS were used in combination as stabilizers.…”

Section: Preparation Of Tadalafil Nanosuspensionmentioning

confidence: 99%

“…Impact of further higher ratios of surfactant on the particle size reduction and stability was not explored and can be further investigated. It seems reasonable to postulate that use of optimum concentration of suitable stabilizer and stirring rate results in fine nanosuspension with smaller and more uniform particle size [15].…”

Section: Characterization Of Tadalafil Nanosuspensionmentioning

confidence: 99%

Formulation Development of Immediate Release Pellets of Tadalafil: Solidification Approach for Nanosuspension

Ubgade¹,

Kilor²,

Bahekar³

et al. 2019

Int J App Pharm

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Objective: Nanosuspension is known to enhance the saturation solubility and dissolution velocity of poorly soluble drugs owing to the increased surface area of nanosized particles. Stability of these solubility enhancing systems can be improved by converting them into solidified forms. To simultaneously achieve enhanced dissolution and improved stability, an attempt has been made to increase the dissolution rate of poorly soluble drug tadalafil by formulating immediate release pellets of its nanosuspension. Methods: Tadalafil nanosuspensions were prepared using high shear homogenization technique and hydroxypropyl methylcellulose (HPMC) E 15, sodium dodecyl sulphate (SDS) as stabilizers. Prepared nanosuspensions were subjected to the characterization of particle size distribution, zeta potential, drug loading and saturation solubility. Optimized nanosuspension was solidified by preparing immediate release pellets: for improved stability, where tadalafil nanosuspension was used as a binder. Pellets were prepared by extrusion-spheronization technique using κ-carrageenan as a pelletizing aid. Results: Prepared immediate release pellets disintegrated within 03 min. In vitro dissolution studies showed 85% drug release within 45 min in pH 1.2 buffer from immediate release pellets containing tadalafil nanosuspension. Conclusion: It can be concluded that formulation of nanosuspension of poorly soluble drug and its use as a binder for the preparation of immediate release pellets markedly improved the dissolution rate.

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“…The study was performed at 37±0.5 ° C with the paddle speed of 50 rpm. At specified time intervals, 5 ml of the sample solution was taken and replaced with fresh dissolution medium [17]. The absorbance of the filtrate was recorded at 231 nm.…”

Section: In Vitro Dissolution Studiesmentioning

confidence: 99%

Design, Optimization and Evaluation of Cetrizine Dihydrochloride Fast Dissolving Films Employing Starch Tartrate–a Novel Superdisintegrant

Kumar

Kumari

Latha

et al. 2019

Int J Curr Pharm Sci

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Objective: The aim of the current research is optimization, preparation and evaluation of starch tartrate (novel super disintegrant) and preparation of fast dissolving oral films of cetirizine dihydrochloride by employing starch tartrate. Methods: To check the drug excipient compatibility studies of the selected drug (Cetrizine dihydrochloride) and the prepared excipient i. e starch tartrate, different studies like FTIR (Fourier-transform infrared spectroscopy), DSC (Differential scanning calorimetry) and thin-layer chromatography (TLC) were carried out to find out whether there is any interaction between cetirizine dihydrochloride and starch tartrate. The solvent casting method was used for the preparation of fast dissolving films. The prepared films were then evaluated for thickness, folding endurance, content uniformity, tensile strength, percent elongation, in vitro disintegration time and in-vitro dissolution studies. Response surface plots and contour plots were also plotted to know the individual and combined effect of starch tartrate (A), croscarmellose sodium (B) and crospovidone (C) on disintegration time and drug dissolution efficiency in 10 min (dependent variables). Results: Films of all the formulations are of good quality, smooth and elegant by appearance. Drug content (100±5%), thickness (0.059 mm to 0.061 mm), the weight of films varies from 51.33 to 58.06 mg, folding endurance (52 to 67 times), tensile strength (10.25 to 12.08 N/mm2). Fast dissolving films were found to disintegrate between 34 to 69 sec. Percent dissolved in 5 min were found to be more in F1 formulation which confirms that starch tartrate was effective at 1%. Conclusion: From the research conducted, it was proved that starch tartrate can be used in the formulation of fast dissolving films of cetirizine dihydrochloride. The disintegration time of the films was increased with increase in concentration of super disintegrant.

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Development of Stable Nanosuspension Loaded Oral Films of Glimepiride With Improved Bioavailability

Cited by 18 publications

References 21 publications

Overview of Mucoadhesive Biopolymers for Buccal Drug Delivery Systems

Overview of Mucoadhesive Biopolymers for Buccal Drug Delivery Systems

Formulation Development of Immediate Release Pellets of Tadalafil: Solidification Approach for Nanosuspension

Design, Optimization and Evaluation of Cetrizine Dihydrochloride Fast Dissolving Films Employing Starch Tartrate–a Novel Superdisintegrant

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