Enhancement of prednisolone dissolution properties using liquisolid compacts

Spireas, Spiro; Sadu, Srinivas

doi:10.1016/s0378-5173(98)00046-5

Cited by 173 publications

(154 citation statements)

References 6 publications

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“…The Φ-value corresponding to an angle of slide of 33° represented the flowable liquid retention potential (Φ-value) of that material. The Phi value for carrier and coating material has been abbreviated as Φ CA and Φ CO respectively 14,15 .…”

Section: Flowablementioning

confidence: 99%

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2017

IJPSR

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Olmesartan medoxomil, a BCS class II drug, is an angiotensin-II receptor antagonist used for the treatment of hypertension. A liquisolid tablet of Olmesartan medoxomil was developed to improve its dissolution and flow properties. The commonly used carrier Avicel was compared with Neusilin. Because of higher liquid load factor, Neusilin was selected as a carrier for further optimization study using 3 2 Factorial design. Two independent factors, % drug concentration in a liquid vehicle (X1) and carrier coating ratio (X2) were studied, each with three levels and the systems was assessed for two dependent variables; % drug dissolution and angle of repose. Mathematical equations and response surface plots were used to relate the dependent and independent variables. All prepared liquisolid formulations were characterized for pre-and post-compression parameters. The optimized formulation F7 (15% drug concentration and 30 carrier coating ratio) was tested for X-ray powder diffractometry and FTIR. Results showed that maximum drug dissolution was exhibited by systems with minimum drug concentration in liquid vehicle and optimum carrier to coating ratio. Optimized formulation displayed significantly enhanced dissolution profiles than that of marketed formulation. In conclusion, avicel could be replaced by neusilin for the formulation of low weight liquisolid tablets along with increased dissolution.

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Section: Flowablementioning

confidence: 99%

“…Calculation of Loading Factor (L f ), amount of Carrier Material (Q) and Coating Material (q) 14,16 : By using Phi value of carrier and coating material, the liquid load factor (L f ) and quantities of carrier and coating materials were calculated by using following formula: …”

Section: Flowablementioning

confidence: 99%

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2017

IJPSR

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“…Concerning the drug concentration in the liquid vehicle, as the drug concentration decreased, the portion solubilized and molecularly dispersed in the liquid vehicle increased thus leading to better dissolution [37][38][39].…”

Section: In Vitro Dissolution Testmentioning

confidence: 99%

Formulation and Evaluation of Furosemide Liquisolid Compact

Jassim

2017

Int J App Pharm

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Objective: The purpose of this study was to enhance the dissolution pattern of the practically water-insoluble diuretic drug, furosemide through its formulation into liquisolid tablets.Methods: A mathematical model was used to formulate four liquisolid powder systems using polyethylene glycol 400 as a non-volatile water miscible liquid vehicle. The liquid loading factors of the vehicle were used to calculate the optimum quantities of carrier (Avicel PH 102) and coating materials (Aerosil 200) needed to prepare acceptably flowing and compactible powder mixtures and (R) ratio used was 25. The liquisolid tablets were evaluated for weight variation, percent friability, hardness, content uniformity, disintegration time and in vitro drug release profile. Drug and the prepared systems were characterized by fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC) and powder xray diffraction (PXRD) studies. Results:The enhanced dissolution rate due to the increased wetting properties and the large available surface areas for dissolution were obtained in case of the liquisolid tablets. The selected optimal formulation (F2) of 50% drug concentration released 90% of its content during the first 10 min compared to 65% of DCT. FTIR studies revealed that there was no interaction between drug and polymers. DSC and PXRD indicated conversion of crystalline to amorphous form of furosemide. Conclusion:The dissolution rate of furosemide can be enhanced to a great extent by liquisolid technique.

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“…Numerous efforts have been made to modify the drug dissolution rate (7)(8)(9)(10). In aqueous solutions, IMC is degraded and its therapeutic activity is impaired.…”

Section: Introductionmentioning

confidence: 99%

Physicochemical Performances of Indomethacin in Cholesteryl Cetyl Carbonate Liquid Crystal as a Transdermal Dosage

et al. 2012

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Abstract. A transdermal formulation of indomethacin (IMC) was developed by incorporation into cholesteryl cetyl carbonate (CCC). The liquid crystalline phase properties of the IMC-CCC mixture were detected by polarized light microscopy and differential scanning calorimetry. A low drug loading was obtained (1-5 %) similar to that used in conventional topical IMC in a clinical setting. A controlled release of IMC was found over 12 h. A low amount of IMC in 1 % IMC-CCC permeated the stratum corneum. Further formulation development has been carried out by the addition of lauryl alcohol into 5 % IMC-CCC mixture it was found that the permeation of IMC was significantly improved to 45 % within 24 h.

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Enhancement of prednisolone dissolution properties using liquisolid compacts

Cited by 173 publications

References 6 publications

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Formulation and Evaluation of Furosemide Liquisolid Compact

Physicochemical Performances of Indomethacin in Cholesteryl Cetyl Carbonate Liquid Crystal as a Transdermal Dosage

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