Formulation and Evaluation of Furosemide Liquisolid Compact

Jassim, Zainab E.

doi:10.22159/ijap.2017v9i6.21458

Cited by 18 publications

(18 citation statements)

References 19 publications

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“…The final mass was checked for their consistency, flowability, and compressibility properties and then compressed into tablets and their texture, hardness were detected. This procedure was repeated by varying the coating: carrier material ratio to improve the flowability and the compressibility properties of the prepared mixtures 18 .…”

Section: Determination Of Liquid Load Factor (Lf)mentioning

confidence: 99%

Untitled

2020

IJPSR

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The present study is undertaken with an aim to improve the dissolution profile and availability of a poorly soluble drug, Lornoxicam, through the development of liquisolid tablets. Liquisolid compacts were prepared by employing PEG 400, Avicel PH 112, and Aerosil 200 as solvent, carrier and coating materials, respectively. The flow properties of the drug improved significantly after formulating it into the liquisolid compacts. The post-compressional parameters of prepared tablets revealed the uniformity and maintenance of standards within the different batches. In-vitro drug release studies showed significant improvement in the dissolution of lornoxicam in its liquisolid form compared to a commercial product. The effect of formulation parameters, such as drug concentration and carrier to coat ratio, on enhancing drug dissolution, was also explored. FT-IR, DSC and XRD techniques were employed for the physical characterization of the drug in the liquisolid systems. The drug release from the optimized liquisolid compacts (F8) followed first-order release kinetics. INTRODUCTION: Solubility is one of the important parameters to achieve the desired concentration of drug in systemic circulation for achieving required pharmacological response. Poorly water-soluble drugs often require high doses in order to reach the therapeutic plasma concentrations after oral administration. Most of the drugs are either weakly acidic or weakly basic, having poor aqueous solubility, thus producing major problems with formulation development of new chemical entities. Hence, a significant number of new and possibly beneficial chemical entities do not have suitable pharmaceutical dosage form because of their poor solubility and poor dissolution rate 1, 2 .

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Section: Determination Of Liquid Load Factor (Lf)mentioning

confidence: 99%

Untitled

2020

IJPSR

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“…After complete incorporation of the liquid medication to the carrier and coating material, 6% w/w of croscarmellose sodium as the disintegrant was added to the mixture and mixed thoroughly. After the final liquid-solid formulation has been produced, the blend was compressed into tablets using rotary tablet press machine with 12 mm round and flat punch with a compression force that provides acceptable tablet hardness [12][13][14].…”

Section: Preparation Of Cinnarizine Liquid-solid Compactsmentioning

confidence: 99%

Cinnarizine Liquid Solid Compacts: Preparation Evaluation

Sisinthy

Selladurai

2019

Int J App Pharm

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Objective: The objective of this research was to formulate cinnarizine tablets using the liquid-solid compact technique to enhance its solubility and dissolution rate.Methods: Cinnarizine liquid-solid compacts were formulated using propylene glycol as the non-volatile solvent, Neusilin US2 as the carrier material, Aerosil 200 as the coating material and croscarmellose sodium as the disintegrant. The interaction between drug and excipients were characterized by Fourier-transform infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC) studies. Different batches of liquid, solid compacts were prepared by using varying carrier-coating excipient ratio and different concentration of liquid medication. Flow parameters such as bulk density, tapped density, Carr’s Index, Hausner’s Ratio as well as an angle of repose were used to test the flowability of the powder blend. The liquid-solid compacts were produced by direct compression method and were evaluated for tests such as weight variation, drug content, hardness, thickness, friability, wetting time, disintegration time as well as the in vitro dissolution studies.Results: The results of the preformulation studies of liquisolid compacts showed acceptable flow properties. The results of FTIR and DSC studies showed that there is no drug-excipient interactions. The different R values and concentrations were found to have a marked effect on the dissolution profile. Formulations with higher carrier: coating ratio (R-value) and lower drug concentrations displayed a better dissolution profile. The percentage of drug release of F3 with an R-value of 20 and a drug concentration of 10% was found to be 88.11% when compared to the conventional marketed tablet which released only 44.07% at the end of 2 h.Conclusion: From this research, it is inferred that liquid-solid technique is a promising and effective approach that can be used to enhance the dissolution rate of cinnarizine.

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“…Three trials for each sample were performed. The samples were analyzed spectrophotometrically at 482nm using 13.5 mol/L sulfuric acid as color developer [17,18].…”

Section: Dissolution Studiesmentioning

confidence: 99%

Formulation and evaluation of liquisolid compact of azithromycin dihydrate

Bhattacharyya¹,

Pasha²,

VERMA³

et al. 2019

Sanat

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Azithromycin dihydrate is a macrolide antibiotic and belongs to BCS class II drugs. The present study aims at the preparation of liquisolid compact of azithromycin dihydrate with an aim to improve the solubility of the drug. The liquid solid system uses a nonvolatile solvent to dissolve the drug. The solution or suspension of drug is converted into a free flowing dry and compressible powder in an admixture of coating and carrier material calculated mathematically. In this study Avicel PH102 and Aerosil 200 were used as carrier and coating material respectively. Propylene glycol was used as the nonvolatile solvent. Using different excipient ratio six formulations were made and evaluated for flowability and compressibility characteristics. Drug excipient interaction study was performed through Fourier transform infrared spectroscopy (FTIR). The formulations were subjected to statistical analysis. Optimization of the formulation was done through JMP V8.0 software. The optimized formulations were evaluated for flowability, compressibility study, thermal analysis by differential scanning calorimetry (DSC) and comparative dissolution study with pure drug. The optimized formulations showed a good flow property and compression characteristics. The FTIR study revealed no physical interaction of the drug with the excipient. The DSC thermograms proved the conversion of crystalline structure of the drug into its amorphous form. The comparative dissolution study of the optimized formulations with the pure drug revealed significant improvement of solubility of azithromycin dihydrate in liquid solid compact. Therefore, it can be concluded that a free flowing, non-adherent, dry and compressible powder of azithromycin dihydrate can be prepared using liquid solid compact technology.

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Formulation and Evaluation of Furosemide Liquisolid Compact

Cited by 18 publications

References 19 publications

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Cinnarizine Liquid Solid Compacts: Preparation Evaluation

Formulation and evaluation of liquisolid compact of azithromycin dihydrate

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