Enhancement of cells proliferation and control of bioactivity of strontium doped glass

Oudadesse, Hassane; Dietrich, Elodie; Bui, Xuan Vuong; Gal, Yann Le; Pellen, Pascal; Cathelineau, Guy

doi:10.1016/j.apsusc.2011.05.022

Cited by 32 publications

(34 citation statements)

References 26 publications

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“…Indeed, the chitosan is introduced in a high amount for 2CH-1BG scaffolds and glass grains trapped in the chitosan absorb more hardly the necessary chemical elements for the formation of hydroxyapatite. However, the integration of bioactive glass with its high bioactivity [35,36] promotes the consumption of calcium and phosphorus to create crystals of hydroxyapatite. Therefore, it explains the formation of hydroxyapatite in materials from 15 days and the ionic exchanges for each scaffold.…”

Section: Methodsmentioning

confidence: 99%

“…This physical method presents a high sensitivity and allows having the kinetic of bioactivity. Indeed, silicon is an indicator of the dissolution of bioactive glass while calcium and phosphorus help to understand the formation of calcium phosphate [35,36]. These chemical elements were measured in the SBF solution at different periods (2, 4, 8 and 16 h and 1, 2, 7, 15 and 30 days).…”

Section: Methodsmentioning

confidence: 99%

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Evaluation of the kinetic and relaxation time of gentamicin sulfate released from hybrid biomaterial Bioglass-chitosan scaffolds

Wers

Oudadesse

Lefeuvre

et al. 2015

Applied Surface Science

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International audienceChitosan scaffolds, combined with bioactive glass 46S6, were prepared to serve as gentamicin sulfate delivery in situ systems for bone biomaterials. This work presents a study about the effect of the ratio chitosan/bioactive glass (CH/BG) on the release of gentamicin sulfate and on the bioactivity during in vitro experiments. SEM observations allowed understanding the bond between the glass grains and the chitosan matrix. In vitro results showed that scaffolds form a hydroxyapatite (HA) Ca10(PO4)6(OH)2 after 15 days of immersion in a simulated body fluid (SBF).The interest of this study is to see that the increase of the content of bioactive glass in the chitosan matrix slows the release of gentamicin sulfate in the liquid medium. Starting concentration of gentamicin sulfate has an influence on the relaxation time of the scaffolds. Indeed, an increasing concentration delays the return to a new equilibrium. Contents of chitosan and bioactive glass do not affect the relaxation time. Synthesized scaffolds could be adapted to a clinical situation: severity and type of infection, weight and age of the patient

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Evaluation of the kinetic and relaxation time of gentamicin sulfate released from hybrid biomaterial Bioglass-chitosan scaffolds

Wers

Oudadesse

Lefeuvre

et al. 2015

Applied Surface Science

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“…[1][2][3][4][5] When a bioactive glass is immersed in the simulated body fluid (SBF) solution or implanted in the human body, a surface hydroxyapatite layer is formed, that has similar composition to the bone, allowing bone grafting. [5][6] The bioactivity mechanism of bioglasses was described by several steps [1,4,7] : (a) rapid exchange of Na + , Ca 2+ ions from materials with H3O + ions in physiological solution; (b) loss of silicic acid Si(OH)4 by breaking of Si-O-Si bridging links and subsequent formation of surface silanol groups in this process; (c) condensation and re-polymerization of SiO2 rich surface layer on the surface; (d) migration of Ca 2+ , PO4 3ions through the silica-rich layer, forming a phosphorous and calcium-rich layer, and a subsequently amorphous calcium phosphate layer, forming a double-layer structure; (e) crystallization of the amorphous calcium phosphate layer by the OH -, CO3 2ion incorporation.…”

Section: Introductionmentioning

confidence: 99%

“…Since the discovery of Hench, many melting derived bioactive glasses have been developed and studied in both in vitro and in vivo experiments. [2][3][6][7] Generally, the melting technique can quickly fabricate the bioglasses and it is suitable for mass production. However, this method has still remained some disadvantages.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of bioactive glass synthesized by alkali‐mediated sol‐gel process

Vương

2019

Vietnam Journal of Chemistry

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The main objective of this research is the elaboration of bioactive glass 58S by an alkali‐mediated sol‐gel method. In which, the ammonia solution was used to transfer sol to gel state, and then the gel was dried by using the free‐drying technique. The dried gel was heated at 700°C in 2 h to convert into glass powder. The XRD analysis confirmed the amorphous and glassy properties of synthetic bioglass. The specific surface area of 99.146 m2/g of this bioglass was identified by using a low‐temperature nitrogen adsorption technique. In vitro experiments were performed by soaking the powder samples in the simulated body fluid (SBF) at several times. The XRD patterns and SEM images high lighted the bioactivity of bioglass by the formation of a dense and visible hydroxyapatite layer on the glass's surface after only 2 days of in vitro assays. ICP‐OES spectrometry was also used to illustrate the ion exchange behaviors between the bioactive glass 58S and the SBF solution.

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“…Bioactive glasses are interfacial reactive materials used as implants in the human body to restore and replace diseased bone [1][2][3]. These materials are called "bioactive" because of the formation of interfa cial bonds between the glass implant and the sur rounding tissues.…”

Section: Introductionmentioning

confidence: 99%