Enhancement of bio-stability and mechanical properties of hyaluronic acid hydrogels by tannic acid treatment

Lee, Ho-Yong; Hwang, Changha; Kim, Hyoun‐Ee; Jeong, Sunjoo

doi:10.1016/j.carbpol.2018.01.056

Cited by 122 publications

(60 citation statements)

References 65 publications

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“…G′ was determined at a strain of 1% and a frequency of 6.3 rad/s, and the injection force was averaged over a linear 2 mm section. 44 Crush was prepared using various amounts of BDDE, and there was an exponential relationship between G′ and the injection force. Also, the Sphere group was confirmed to exhibit a low injection force and high G′.…”

Section: Resultsmentioning

confidence: 99%

Hyaluronic Acid-Based Hybrid Hydrogel Microspheres with Enhanced Structural Stability and High Injectability

et al. 2019

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For hydrogel injection applications, it is important to improve the strength and biostability of the hydrogel as well as its injectability to pass easily through the needle. Making gel microspheres is one approach to achieve these improvements. Granulization of a bulk hydrogel is a common procedure used to form microsized particles; however, the nonuniform size and shape cause an uneven force during injection, damaging the surrounding tissue and causing pain to the patients. In this study, injectable hyaluronic acid (HA)-based hybrid hydrogel microspheres were fabricated using a water-in-oil emulsion process. The injectability was significantly enhanced because of the relatively uniform size and spherical shape of the hydrogel formulates. In addition, the biostability and mechanical strength were also increased owing to the increased cross-linking density compared with that of conventionally fabricated gel microparticles. This tendency was further improved after in situ calcium phosphate precipitation. Our findings demonstrate the great potential of HA-based hydrogel microspheres for various clinical demands requiring injectable biomaterials.

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Section: Resultsmentioning

confidence: 99%

Hyaluronic Acid-Based Hybrid Hydrogel Microspheres with Enhanced Structural Stability and High Injectability

et al. 2019

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“…Hyaluronic acid-based hydrogels undergo rapid degradation processes which limit the range of their applications. Tannic acid has been studied as a hyaluronic acid physical cross-linker in a hydrogel form [ 69 ]. It interacts by hydrogen bonding and enhances the material physicochemical properties.…”

Section: Tannic Acid-based Biomaterialsmentioning

confidence: 99%

Tannic Acid with Antiviral and Antibacterial Activity as A Promising Component of Biomaterials—A Minireview

2020

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As a phenolic acid, tannic acid can be classified into a polyphenolic group. It has been widely studied in the biomedical field of science because it presents unique antiviral as well as antibacterial properties. Tannic acid has been reported to present the activity against Influeneza A virus, Papilloma viruses, noroviruses, Herpes simplex virus type 1 and 2, and human immunodeficiency virus (HIV) as well as activity against both Gram-positive and Gram-negative bacteria as Staphylococcus aureus, Escherichia coli, Streptococcus pyogenes, Enterococcus faecalis, Pseudomonas aeruginosa, Yersinia enterocolitica, Listeria innocua. Nowadays, compounds of natural origin constitute fundaments of material science, and the trend is called “from nature to nature”. Although biopolymers have found a broad range of applications in biomedical sciences, they do not present anti-microbial activity, and their physicochemical properties are rather poor. Biopolymers, however, may be modified with organic and inorganic additives which enhance their properties. Tannic acid, like phenolic acid, is classified into a polyphenolic group and can be isolated from natural sources, e.g., a pure compound or a component of a plant extract. Numerous studies have been carried out over the application of tannic acid as an additive to biopolymer materials due to its unique properties. On the one hand, it shows antimicrobial and antiviral activity, while on the other hand, it reveals promising biological properties, i.e., enhances the cell proliferation, tissue regeneration and wound healing processes. Tannic acid is added to different biopolymers, collagen and polysaccharides as chitosan, agarose and starch. Its activity has been proven by the determination of physicochemical properties, as well as the performance of in vitro and in vivo studies. This systematics review is a summary of current studies on tannic acid properties. It presents tannic acid as an excellent natural compound which can be used to eliminate pathogenic factors as well as a revision of current studies on tannic acid composed with biopolymers and active properties of the resulting complexes.

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“…Agarose-based hydrogels with tannic acid addition also show improved mechanical properties when compared to those without TA addition. Tannic acid has also been studied in combination with starch [129], silk fibroin [130], hyaluronic acid [131], and cellulose [132]. For all the complexes, an improvement in physicochemical and biological properties was noticed.…”

Section: Phenolic Acids With Other Natural Polymersmentioning

confidence: 99%

Collagen-Based Materials Modified by Phenolic Acids—A Review

Kaczmarek

Mazur

2020

Materials

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Collagen-based biomaterials constitute one of the most widely studied types of materials for biomedical applications. Low thermal and mechanical parameters are the main disadvantages of such structures. Moreover, they present low stability in the case of degradation by collagenase. To improve the properties of collagen-based materials, different types of cross-linkers have been researched. In recent years, phenolic acids have been studied as collagen modifiers. Mainly, tannic acid has been tested for collagen modification as it interacts with a polymeric chain by strong hydrogen bonds. When compared to pure collagen, such complexes show both antimicrobial activity and improved physicochemical properties. Less research reporting on other phenolic acids has been published. This review is a summary of the present knowledge about phenolic acids (e.g., tannic, ferulic, gallic, and caffeic acid) application as collagen cross-linkers. The studies concerning collagen-based materials with phenolic acids are summarized and discussed.

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Enhancement of bio-stability and mechanical properties of hyaluronic acid hydrogels by tannic acid treatment

Cited by 122 publications

References 65 publications

Hyaluronic Acid-Based Hybrid Hydrogel Microspheres with Enhanced Structural Stability and High Injectability

Hyaluronic Acid-Based Hybrid Hydrogel Microspheres with Enhanced Structural Stability and High Injectability

Tannic Acid with Antiviral and Antibacterial Activity as A Promising Component of Biomaterials—A Minireview

Collagen-Based Materials Modified by Phenolic Acids—A Review

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