Enhancement by lactose of intestinal alkaline phosphatase expression in rats

Sogabe, Natsuko; Mizoi, Lena; Asahi, Kumiko; Ezawa, Ikuko; Goseki‐Sone, Masae

doi:10.1016/j.bone.2004.02.007

Cited by 22 publications

(14 citation statements)

References 38 publications

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“…It has recently been shown that dietary lactose increases the level of ALP activity, especially in the jejunum (Sogabe, Mizoi, Asahi, Ezawa, & Goseki-Sone, 2004). In our study, the highest ALP activity was found in 1-month-old mice in the duodenum and jejunum.…”

mentioning

confidence: 56%

The Influence of Age on Intestinal Dipeptidyl Peptidase IV (DPP IV/CD26), Disaccharidases, and Alkaline Phosphatase Enzyme Activity in C57BL/6 Mice

Detel

Batičić

Varljen

2007

Experimental Aging Research

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The objective of this study was to determine and describe the age-related changes in intestinal brush border membrane enzyme activities that occur in C57Bl/6 mice. Specifically, jejunal, duodenal, and ileal dipeptidyl peptidase IV/CD26, disaccharidase (lactase, sucrase, and maltase), and alkaline phosphatase activities were determined. A significant correlation between analyzed intestinal brush border membrane enzyme activities and animal age was found. Our study revealed that intestinal dipeptidyl peptidase IV/CD26, lactase, sucrase, maltase, and alkaline phosphatase activities decline significantly with age (p < .05). Nevertheless, the horizontal (duodenum to ileum) enzyme activity patterns are not affected by age.

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confidence: 56%

The Influence of Age on Intestinal Dipeptidyl Peptidase IV (DPP IV/CD26), Disaccharidases, and Alkaline Phosphatase Enzyme Activity in C57BL/6 Mice

Detel

Batičić

Varljen

2007

Experimental Aging Research

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“…There are various hypotheses concerning the calcium absorption‐promoting action of lactose: It has been reported that lactose increased calcium permeability in small intestinal villi (18), an increase in intestinal lactic acid bacteria decreased intestinal pH and promoted calcium absorption (32, 33), and lactose formed chelates or complexes (34), but many points remain unclear regarding the mechanisms. Previously, we reported that intestinal alkaline phosphatase activity in the rat intestine was markedly enhanced after 21 days of being fed a 10% lactose diet, and lactose is one of the factors responsible for intestinal alkaline phosphatase activity (35).…”

Section: Discussionmentioning

confidence: 99%

Effects of Dietary Lactose on Long‐term High‐fat‐diet‐induced Obesity in Rats

Goseki‐Sone

Maruyama

Sogabe

et al. 2007

Obesity

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GOSEKI-SONE, MASAE, RIEKO MARUYAMA, NATSUKO SOGABE, AND TAKAYUKI HOSOI. Effects of dietary lactose on long-term high-fat-diet-induced obesity in rats. Obesity. 2007;15:2605-2613. Objective: In this study, we examined the effects of lactose on long-term high-fat-diet-induced obesity in rats. Research Methods and Procedures:A total of 112 Sprague-Dawley strain female rats (6 weeks old) were divided into four groups: a basic control diet group (Cont), 10% lactose diet group (Lac), high-fat diet group (Fat), and high-fat with 10% lactose diet group (FatϩLac). After 0, 7, 14, and 84 days from starting the experimental diet, the animals were fasted overnight and killed by bleeding from the abdominal aorta under anesthesia (n ϭ 8 or 9/group). Results: After 84 days, the addition of lactose to the high-fat diet decreased the final body weight, body weight gain, fat accumulation, and the levels of serum leptin, serum triglycerides, and serum glucose significantly (p Ͻ 0.05). Although there was no significant difference in the levels of serum calcium and phosphorus between the Fat and FatϩLac groups, lumbar vertebral bone mineral density was significantly higher in the FatϩLac group than in the Cont group on Day 82. Interestingly, the level of serum 1␣, 25-dihydroxyvitamin D 3 in the FatϩLac group on Day 84 was reduced by 74% compared with the Fat group (p Ͻ 0.01), while there was no significant difference in serum parathyroid hormone levels between the Fat and FatϩLac groups. Discussion: This is the first study to suggest that the addition of lactose to a long-term high-fat diet may regulate not only calcium metabolism but also fat deposition. Further studies on the mechanism of dietary lactose in the regulation of adiposity would provide valuable data for the prevention of long-term high-fat-diet-induced obesity.

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“…Most simple or complex carbohydrates, including lactose, starch, cereals, and cellulose, stimulate IAP activity in the small intestine while guar gum, which is a soluble and fermentable fiber, decreases it 94–98 . All fiber sources enhanced IAP activity in the colon, leading to the suggestion that both fermentability of and mechanical stimulation by fiber stimulate colonic epithelial proliferation and IAP activity 16 …”

Section: Intestinal Alkaline Phosphatase and The Dietmentioning

confidence: 99%

Intestinal alkaline phosphatase: multiple biological roles in maintenance of intestinal homeostasis and modulation by diet

Lallès¹

2010

Nutrition Reviews

309

284

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The diverse nature of intestinal alkaline phosphatase (IAP) functions has remained elusive, and it is only recently that four additional major functions of IAP have been revealed. The present review analyzes the earlier literature on the dietary factors modulating IAP activity in light of these new findings. IAP regulates lipid absorption across the apical membrane of enterocytes, participates in the regulation of bicarbonate secretion and of duodenal surface pH, limits bacterial transepithelial passage, and finally controls bacterial endotoxin-induced inflammation by dephosphorylation, thus detoxifying intestinal lipopolysaccharide. Many dietary components, including fat, protein, and carbohydrate, modulate IAP expression or activity and may be combined to sustain a high level of IAP activity. In conclusion, IAP has a pivotal role in intestinal homeostasis and its activity could be increased through the diet. This is especially true in pathological situations (e.g., inflammatory bowel diseases) in which the involvement of commensal bacteria is suspected and when intestinal AP is too low to detoxify a sufficient amount of bacterial lipopolysaccharide.

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Enhancement by lactose of intestinal alkaline phosphatase expression in rats

Cited by 22 publications

References 38 publications

The Influence of Age on Intestinal Dipeptidyl Peptidase IV (DPP IV/CD26), Disaccharidases, and Alkaline Phosphatase Enzyme Activity in C57BL/6 Mice

The Influence of Age on Intestinal Dipeptidyl Peptidase IV (DPP IV/CD26), Disaccharidases, and Alkaline Phosphatase Enzyme Activity in C57BL/6 Mice

Effects of Dietary Lactose on Long‐term High‐fat‐diet‐induced Obesity in Rats

Intestinal alkaline phosphatase: multiple biological roles in maintenance of intestinal homeostasis and modulation by diet

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