The Influence of Age on Intestinal Dipeptidyl Peptidase IV (DPP IV/CD26), Disaccharidases, and Alkaline Phosphatase Enzyme Activity in C57BL/6 Mice

Detel, Dijana; Batičić, Lara; Varljen, Jadranka

doi:10.1080/03610730701761957

Cited by 19 publications

(17 citation statements)

References 27 publications

(23 reference statements)

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“…They increase to adult values at the time of weaning, between 20 and 24 days of life, suggesting the influence of dietary changes at that period. AP activity all along the small intestine decreases by 50% in elderly rats and mice 21,22 …”

Section: Alkaline Phosphatases: Backgroundmentioning

confidence: 97%

“…In rodents, intestinal AP gene expression and enzyme activity remain low during the suckling period 20,21 . They increase to adult values at the time of weaning, between 20 and 24 days of life, suggesting the influence of dietary changes at that period.…”

Section: Alkaline Phosphatases: Backgroundmentioning

confidence: 99%

“…Similarly, colonic IAP mRNA levels were reduced in aged rats borne with a low body weight (JP Segain, personal communication). Such observations may have important implications in terms of nutrition (obesity) and health (inflammation, sepsis) for adult and elderly populations, due to the multiple protective roles of IAP and its decreased activity with aging 21,22 …”

Section: Intestinal Alkaline Phosphatase and The Dietmentioning

confidence: 99%

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Intestinal alkaline phosphatase: multiple biological roles in maintenance of intestinal homeostasis and modulation by diet

Lallès¹

2010

Nutrition Reviews

309

284

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The diverse nature of intestinal alkaline phosphatase (IAP) functions has remained elusive, and it is only recently that four additional major functions of IAP have been revealed. The present review analyzes the earlier literature on the dietary factors modulating IAP activity in light of these new findings. IAP regulates lipid absorption across the apical membrane of enterocytes, participates in the regulation of bicarbonate secretion and of duodenal surface pH, limits bacterial transepithelial passage, and finally controls bacterial endotoxin-induced inflammation by dephosphorylation, thus detoxifying intestinal lipopolysaccharide. Many dietary components, including fat, protein, and carbohydrate, modulate IAP expression or activity and may be combined to sustain a high level of IAP activity. In conclusion, IAP has a pivotal role in intestinal homeostasis and its activity could be increased through the diet. This is especially true in pathological situations (e.g., inflammatory bowel diseases) in which the involvement of commensal bacteria is suspected and when intestinal AP is too low to detoxify a sufficient amount of bacterial lipopolysaccharide.

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Section: Alkaline Phosphatases: Backgroundmentioning

confidence: 97%

Section: Alkaline Phosphatases: Backgroundmentioning

confidence: 99%

Section: Intestinal Alkaline Phosphatase and The Dietmentioning

confidence: 99%

See 1 more Smart Citation

Intestinal alkaline phosphatase: multiple biological roles in maintenance of intestinal homeostasis and modulation by diet

Lallès¹

2010

Nutrition Reviews

309

284

View full text Add to dashboard Cite

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“…Effect of PPA on Sucrase and Isomaltase Activities of SI-SI catalyzes the hydrolysis of sucrose and about 80% of dietary maltose, whereas maltase-glucoamylase (EC 3.2.1.20/3) catalyzes the hydrolysis of the remaining maltose (44,45). Maltose is produced when ␣-amylase breaks down starch (46).…”

Section: Effect Of Bbmv On Starch Degradation By Ppa-as Shown Inmentioning

confidence: 99%

Functional Regulation of Sugar Assimilation by N-Glycan-specific Interaction of Pancreatic α-Amylase with Glycoproteins of Duodenal Brush Border Membrane

Asanuma-Date

Hirano

et al. 2012

Journal of Biological Chemistry

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Background: PPA binds to specific glycoprotein N-glycans. Results: Interaction between PPA and glycoligands in duodenum BBM activates glucose production while inhibiting glucose absorption by enterocytes. Conclusion: N-Glycans in BBM function as a target for ␣-amylase in order to control glucose assimilation via their interaction. Significance: We have discovered the modulatory role of BBM glycoprotein N-glycans, which contribute to blood glucose homeostasis.

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“…In fact, at 42 days of age the activity is increasing toward its highest level and at 1 year it is decreasing toward its lowest level 13. Moreover, an early study showed that the adaptive response of the intestine is reduced in old age 27.…”

Section: Discussionmentioning

confidence: 99%

Maternal protein restriction affects gene expression and enzyme activity of intestinal disaccharidases in adult rat offspring

Pinheiro

Pacheco

Alvarenga

et al. 2013

Braz J Med Biol Res

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This study investigated the consequences of intrauterine protein restriction on the gastrointestinal tract and particularly on the gene expression and activity of intestinal disaccharidases in the adult offspring. Wistar rat dams were fed isocaloric diets containing 6% protein (restricted, n = 8) or 17% protein (control, n = 8) throughout gestation. Male offspring (n = 5-8 in each group) were evaluated at 3 or 16 weeks of age. Maternal protein restriction during pregnancy produced offspring with growth restriction from birth (5.7 ± 0.1 vs 6.3 ± 0.1 g; mean ± SE) to weaning (42.4 ± 1.3 vs 49.1 ± 1.6 g), although at 16 weeks of age their body weight was similar to control (421.7 ± 8.9 and 428.5 ± 8.5 g). Maternal protein restriction also increased lactase activity in the proximal (0.23 ± 0.02 vs 0.15 ± 0.02), medial (0.30 ± 0.06 vs 0.14 ± 0.01) and distal (0.43 ± 0.07 vs 0.07 ± 0.02 U·g-1·min-1) small intestine, and mRNA lactase abundance in the proximal intestine (7.96 ± 1.11 vs 2.38 ± 0.47 relative units) of 3-week-old offspring rats. In addition, maternal protein restriction increased sucrase activity (1.20 ± 0.02 vs 0.91 ± 0.02 U·g-1·min-1) and sucrase mRNA abundance (4.48 ± 0.51 vs 1.95 ± 0.17 relative units) in the duodenum of 16-week-old rats. In conclusion, the present study shows for the first time that intrauterine protein restriction affects gene expression of intestinal enzymes in offspring.

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The Influence of Age on Intestinal Dipeptidyl Peptidase IV (DPP IV/CD26), Disaccharidases, and Alkaline Phosphatase Enzyme Activity in C57BL/6 Mice

Cited by 19 publications

References 27 publications

Intestinal alkaline phosphatase: multiple biological roles in maintenance of intestinal homeostasis and modulation by diet

Intestinal alkaline phosphatase: multiple biological roles in maintenance of intestinal homeostasis and modulation by diet

Functional Regulation of Sugar Assimilation by N-Glycan-specific Interaction of Pancreatic α-Amylase with Glycoproteins of Duodenal Brush Border Membrane

Maternal protein restriction affects gene expression and enzyme activity of intestinal disaccharidases in adult rat offspring

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