Enhanced transdermal delivery of an anti-HIV agent via ethanolic liposomes

Dubey, Vaibhav; Mishra, Dinesh Kumar; Nahar, Manoj; Jain, Vikas; Jain, Narendra Kumar

doi:10.1016/j.nano.2010.01.002

Cited by 95 publications

(40 citation statements)

References 31 publications

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“…It has been reported that liposomes could not deeply penetrate the skin but were confined to the upper layers of the stratum corneum. 42 In contrast, ethosomes could increase the mobility of skin lipids, enhancing drug permeation into the stratum corneum due to their excellent deformability. 43 The shortchain alcohols added in ethosomes crucially affect the performance of percutaneous absorption.…”

Section: Discussionmentioning

confidence: 99%

Essential oil-mediated glycerosomes increase transdermal paeoniflorin delivery: optimization, characterization, and evaluation in vitro and in vivo

Zhang

et al. 2017

IJN

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In this study, a novel glycerosome carrier containing essential oils was prepared for topical administration of paeoniflorin (PF) to enhance its transdermal drug delivery and improve drug absorption in the synovium. The formulation of glycerosomes was optimized by a uniform design, and the final vehicle was composed of 5% (w/v) phospholipid, 0.6% (w/v) cholesterol, and 10% (v/v) glycerol, with 2% (v/v) Speranskia tuberculata essential oil (STO) as the transdermal enhancer. The in vitro transdermal flux of PF loaded in the STO-glycerosomes was 1.4-fold, 1.6-fold, and 1.7-fold higher than those of glycerosomes, liposomes, and tinctures, respectively. In vivo studies showed that the use of STO-glycerosomes was associated with a 3.1-fold greater accumulation of PF in the synovium than that of common glycerosomes. This finding was confirmed by in vivo imaging studies, which found that the fluorescence intensity of Cy5.5-loaded STO-glycerosomes in mice knee joints was 1.8-fold higher than that of the common glycerosomes 5 h after administration. The glycerosomes mediated by STO exhibited considerable skin permeability as well as improved drug absorption in the synovium, indicating that STO-glycerosomes may be a potential PF transdermal delivery vehicle for the treatment of rheumatoid arthritis caused by synovium lesions.

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Section: Discussionmentioning

confidence: 99%

Essential oil-mediated glycerosomes increase transdermal paeoniflorin delivery: optimization, characterization, and evaluation in vitro and in vivo

Zhang

et al. 2017

IJN

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“…The organic phase is obtained by dissolving the phospholipids (in addition to surfactants or penetration enhancer for transethosomes) in ethanol or mixture of solvents (ethanol/PG) for the preparation of binary ethosomes, 13 at room temperature, 73 or at 30°C. 6 The aqueous phase used is either water, 44,74,75 buffer solution, 76,77 or normal saline solution. 78 The aqueous phase is added to the organic phase in a fine stream, 6 dropwise, 41 or using a syringe pump at a constant rate of 1 75 or 200 µL/min.…”

Section: Preparation Techniques and Their Effects On Ethosomal Propermentioning

confidence: 99%

Ethosomal nanocarriers: the impact of constituents and formulation techniques on ethosomal properties, in vivo studies, and clinical trials

Abdulbaqi

Darwis

Khan

et al. 2016

IJN

280

179

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Ethosomal systems are novel lipid vesicular carriers containing a relatively high percentage of ethanol. These nanocarriers are especially designed for the efficient delivery of therapeutic agents with different physicochemical properties into deep skin layers and across the skin. Ethosomes have undergone extensive research since they were invented in 1996; new compounds were added to their initial formula, which led to the production of new types of ethosomal systems. Different preparation techniques are used in the preparation of these novel carriers. For ease of application and stability, ethosomal dispersions are incorporated into gels, patches, and creams. Highly diverse in vivo models are used to evaluate their efficacy in dermal/transdermal delivery, in addition to clinical trials. This article provides a detailed review of the ethosomal systems and categorizes them on the basis of their constituents to classical ethosomes, binary ethosomes, and transethosomes. The differences among these systems are discussed from several perspectives, including the formulation, size, ζ-potential (zeta potential), entrapment efficiency, skin-permeation properties, and stability. This paper gives a detailed review on the effects of ethosomal system constituents, preparation methods, and their significant roles in determining the final properties of these nanocarriers. Furthermore, the novel pharmaceutical dosage forms of ethosomal gels, patches, and creams are highlighted. The article also provides detailed information regarding the in vivo studies and clinical trials conducted for the evaluation of these vesicular systems.

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“…System of water, oil and an amphiphile, which forms a single optically isotropic liquid solution Plasmid DNA, ketoprofen, apomorphine, estradiol and lidocaine [134][135][136][137][138] Liposomes Vesicles formed by one or multiple lipid bilayers made of mixture of phospholipids Cosmetics, antibiotics and vaccine adjuvants [139][140][141] Niosomes Mixtures of nonionic surfactants, cholesterol and phospholipids Tretinoin, peptide drugs and zidovudine [142][143][144] Ethosomes Increase skin penetration by increasing the elasticity of the lipidic vesicle; contain up to 20-45% ethanol 5-ALA, salbutamol, finasteride and anti-HIV therapy [145][146][147][148] Transfersomes Phospholipids with surfactants that act to provide vesicle elasticity and deformability…”

Section: Nanoemulsion or Microemulsionmentioning

confidence: 99%