2019
DOI: 10.1021/acsami.9b11877
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Abstract: Laccases are multi-copper oxidase enzymes having widespread applications in various biotechnological fields. However, low stability of free enzymes restricts their industrial use. Development of effective methods to preserve and even increase the enzymatic activity is critical to maximize their use, though this remains a challenge. In the present study we immobilized Trametes versicolor laccase on pH-responsive (and charge-switchable) Pluronic-stabilized silver nanoparticles (AgNPsTrp). Our results demonstrate… Show more

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Cited by 40 publications
(23 citation statements)
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“…The comparative analysis of the hydrated size of AgNPs-1/2 and P-AgNPs-1/2 shows the degree of increase in hydrated particle size is not consistent with the molecular weight of polymer. Chauhan et al found that this may be relate to the e ciency of polymer adsorption on the surface of AgNPs [35]. Hence, the increase in the nano size of P-SH5000 and PVP indicates that they have strong adsorption to AgNPs.…”
Section: Discussionmentioning
confidence: 99%
“…The comparative analysis of the hydrated size of AgNPs-1/2 and P-AgNPs-1/2 shows the degree of increase in hydrated particle size is not consistent with the molecular weight of polymer. Chauhan et al found that this may be relate to the e ciency of polymer adsorption on the surface of AgNPs [35]. Hence, the increase in the nano size of P-SH5000 and PVP indicates that they have strong adsorption to AgNPs.…”
Section: Discussionmentioning
confidence: 99%
“…24,25 Pluronic as a stabilizing agent can successfully be used to overcome this limitation as shown by us and several other groups. 12,26 Apart from biological stability, the other most important parameter affecting the efficacy of a drug delivery system is its uptake by the target cells. 27 Extensive research in last two decades or so have revealed that properties of nanoparticles such as bulk composition, surface parameters (charge, hydrophobicity, elasticity, and targeting ligand), size, and morphology can influence their uptake by the target cells.…”
Section: Discussionmentioning
confidence: 99%
“…However, one of the major limitations of using protein nanoparticles as drug delivery system is their hydrophobicity resulting into aggregation and/or opsonization and in turn low circulation half‐life 24,25 . Pluronic as a stabilizing agent can successfully be used to overcome this limitation as shown by us and several other groups 12,26 . Apart from biological stability, the other most important parameter affecting the efficacy of a drug delivery system is its uptake by the target cells 27 .…”
Section: Discussionmentioning
confidence: 99%
“…Recent study of [19] which the inhibition cell growth against MCF-7 cell line by Coriolus versicolor extract. Moreover, the percentages of MCF7 cell proliferation inhibition by Xanthium strumarium extract have maximum compared with doxorubicin [20].…”
Section: Cell Line Growth and Cytotoxicity Assaymentioning
confidence: 91%