2021
DOI: 10.1002/jbm.a.37287
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Balancing loading, cellular uptake, and toxicity of gelatin‐pluronic nanocomposite for drug delivery: Influence of HLB of pluronic

Abstract: In this study, pluronic stabilized gelatin nanocomposite of varying hydrophilic-lipophilic balance (HLB) were synthesized to study the effect of surface hydrophobicity on their cellular uptake and in turn the delivery of a model hydrophobic bioactive compound, curcumin (CUR). Notably, the variation in HLB from 22 to 8 did not cause much change in morphology (~spherical) and surface charge (~À6.5 mV) while marginally reducing the size of nanocomposite from 165 ± 097 nm to 134 ± 074 nm. On contrary, nanocomposit… Show more

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Cited by 9 publications
(4 citation statements)
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“…It is well known that the hydrophilic–lipophilic balance (HLB) of cancer cell membranes is altered, with an increase in cell permeability and enhanced hydrophilic character. Hence, for example, the uptake of hydrophobic curcumin microencapsulated by A549 cells is highest for submicron pluronic-stabilized gelatin particles with the lowest hydrophobicity [ 29 ]. We make the hypothesis that the cellular uptake of both hydrophobic PUFA molecules in triglyceride form (and vitamin D 3 ) [ 30 ] of AnchoisOil, encapsulated and stabilized in the inner porosity of the highly hydrophilic mesoporous silica via endocytosis and direct translocation [ 31 ], is significantly enhanced when compared to the free hydrophobic molecules in the hydrophilic cellular medium.…”
Section: Discussionmentioning
confidence: 99%
“…It is well known that the hydrophilic–lipophilic balance (HLB) of cancer cell membranes is altered, with an increase in cell permeability and enhanced hydrophilic character. Hence, for example, the uptake of hydrophobic curcumin microencapsulated by A549 cells is highest for submicron pluronic-stabilized gelatin particles with the lowest hydrophobicity [ 29 ]. We make the hypothesis that the cellular uptake of both hydrophobic PUFA molecules in triglyceride form (and vitamin D 3 ) [ 30 ] of AnchoisOil, encapsulated and stabilized in the inner porosity of the highly hydrophilic mesoporous silica via endocytosis and direct translocation [ 31 ], is significantly enhanced when compared to the free hydrophobic molecules in the hydrophilic cellular medium.…”
Section: Discussionmentioning
confidence: 99%
“…The ratio of both components is known as the hydrophilic–lipophilic balance (HLB) of surfactant agents and is related to the ability to interact with different drugs. F‐108 is a more hydrophilic compound than P‐123, presenting HLB values equal to 27 and 8, respectively 23,24 . The use of polymers with a higher hydrophilic or lipophilic character will allow obtaining micelles with dissimilar characteristics in order to select the best delivery system for NR and NRBr.…”
Section: Introductionmentioning
confidence: 99%
“…F-108 is a more hydrophilic compound than P-123, presenting HLB values equal to 27 and 8, respectively. 23,24 The use of polymers with a higher hydrophilic or lipophilic character will allow obtaining micelles with dissimilar characteristics in order to select the best delivery system for NR and NRBr.…”
mentioning
confidence: 99%
“…As a biomass material, gelatin had the advantages of biocompatibility, non-toxicity, vast source, and low cost [3][4][5]. Gelatin was used in various fields, such as food packaging [6][7][8], tissue engineering [9][10][11], drug delivery [12][13][14], adhesives [15][16][17], and so on. Among those applications, adhesives were considered the most promising application direction for the gelatin extracted from skin waste.…”
Section: Introductionmentioning
confidence: 99%