Enhanced Skin Permeation of Hydrocortisone Using Nanoemulsion as Potential Vehicle

Abstract

The current work was performed to estimate the solubility and Hansen solubility parameters of a poorly soluble corticosteroid hydrocortisone (HCN) in various components of nanoemulsion and to enhance the skin permeation rate of HCN using nanoemulsions as potential vehicles. Screening studies suggested the use of Capryol-90 (oil), Triton-X100 (surfactant) and Transcutol-HP (cosurfactant) in the preparation of HCN nanoemulsions. HCN nanoemulsions were developed using low energy emulsification technique and characterized for droplet size, plolydispersity index (PDI), zeta potential (ZP), refractive index (RI), percent of transmittance (% T) and transmission electron microscopy (TEM) and evaluated for drug release behavior. Selected nanoemulsions and control (HCN suspension) were subjected to in vitro skin permeation studies. Optimized formula HSN8 showed droplet size of 52.6 nm, PDI of 0.109, ZP of À 33.72 mV, RI of 1.337 and % T of 97.68%. TEM confirmed spherical-shaped droplets in nanometer range. In vitro drug release evaluation suggested significant release of HCN from optimized nanoemulsion (98.52%) compared with control (35.85%). Skin permeation profile of HCN from optimized nanoemulsion was also significant compared with control. These results suggested the potential of nanoemulsion in enhancing the transdermal delivery of HCN via rat skin.[a] Dr.

Nanoemulsification Improves the Pharmaceutical Properties and Bioactivities of Niaouli Essential Oil (Melaleuca quinquenervia L.)

“…The maximum permeation of formulation NEO-NE 4 is perhaps due to its small droplet diameter and low viscosity as compared to other formulations. These results were found to be in good agreement with those reported for the skin permeation of caffeine, lemongrass oil, 5-fluorouracil, and hydrocortisone from NEs [ 9 , 12 , 33 , 34 ]. The probable mechanism by which NE formulations enhance the skin permeation of drugs is the lipid pathway of the stratum corneum, in which neutral lipids are arranged as bilayer structures with their hydrophobic chains facing each other to form a lipophilic bimolecular leaflet [ 32 ].…”

“…For each phase diagram, the oil phase (NEO) and a particular S mix ratio were mixed thoroughly in the volume ratios of 1:9–9:1. Aqueous phase titration was performed for each S mix ratio separately [ 9 , 29 ]. Visual observations were performed to identify the clear/transparent and easily flowable NE zones.…”

“…Topical drug delivery carriers offer several advantages over conventional routes of drug administration, especially when localized action is required [ 6 ]. In the last decade, the attention of several researchers has focused on nanoemulsion (NE) systems as alternative drug carriers to polymeric and lipid nanoparticles, as they combine many advantages and avoid most disadvantages associated with other colloidal drug carriers [ 8 , 9 , 10 , 11 ]. The NE technique is one the most studied techniques for enhancing the topical administration of essential oils with special regard to thermodynamic stability, protection of labile drugs from degradation, and excellent tolerability pattern [ 12 , 13 , 14 , 15 ].…”

New Insights on Solvent Implications in the Design of Materials Based on Cellulose Derivatives Using Experimental and Theoretical Approaches

“…The distance between the total solubility parameters of the solvent and polymer, respectively, also named the solubility parameter distance, R a , is given by the following equation (Equation ( 22)) [35,[55][56][57]:…”

Solubilization of Trans-Resveratrol in Some Mono-Solvents and Various Propylene Glycol + Water Mixtures

“…It was evidenced that the maximum solubility/miscibility between the solute and mono-solvent is attained if is smaller than 5.0 MPa 1/2 [ 37 , 55 ]. The R a between TRV and the mono-solvent was determined using Equation (4) [ 34 , 56 ]: …”