Enhanced running wheel activity of both Mch1r- and Pmch-deficient mice

Zhou, Dan; Shen, Zhu; Strack, Alison M.; Marsh, Donald J.; Shearman, Lauren P.

doi:10.1016/j.regpep.2004.06.026

Cited by 66 publications

(46 citation statements)

References 56 publications

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“…Mice with targeted deletion of the genes encoding either pre-pro MCH or the MCH-1 receptor display increased home-cage locomotor activity [15,[32][33][34][35] and running wheel activity [14]. This suggests that endogenous MCH exerts an inhibitory effect on locomotor energy expenditure.…”

Section: Discussionmentioning

confidence: 99%

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The orexigenic effect of melanin-concentrating hormone (MCH) is influenced by sex and stage of the estrous cycle

Santollo

Eckel

2008

Physiology & Behavior

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Recently, it was shown that that the orexigenic effect of melanin concentrating hormone (MCH) is attenuated by estradiol treatment in ovariectomized (OVX) rats. This suggests that female rats may be less responsive than male rats to the behavioral effects of MCH. To investigate this hypothesis, the effects of lateral ventricular infusions of MCH on food intake, water intake, meal patterns, and running wheel activity were examined in male and female rats. To further characterize the impact of estradiol on MCH-induced food intake, female rats were OVX and tested with and without 17-β-estradiol benzoate (EB) replacement. In support of our hypothesis, food and water intakes following MCH treatment were greater in male rats, relative to female rats. Specifically, the orexigenic effect of MCH was maximal in male rats and minimal in EB-treated OVX rats. In both sexes, the orexigenic effect of MCH was mediated by a selective increase in meal size, which was attenuated in EB-treated OVX rats. MCH induced a short-term (2 h) decrease in wheel running that, unlike its effects on ingestive behavior, was similar in males and females. Thus, estradiol decreases some, but not all, of the behavioral effects of MCH. To examine the influence of endogenous estradiol, food intake was monitored following MCH treatment in ovarian-intact, cycling rats. As predicted by our findings in OVX rats, the orexigenic effect of MCH was attenuated in estrous rats, relative to diestrous rats. We conclude that the female rat's reduced sensitivity to the orexigenic effect of MCH may contribute to sex-and estrous cycle-related differences in food intake.

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Section: Discussionmentioning

confidence: 99%

“…Finally, i.c.v. infusion of MCH decreases core body temperature [11,12], and targeted deletion of the genes encoding either pre-pro MCH or the MCH-1 receptor stimulates locomotor activity, metabolic energy expenditure, and thermogenesis [13][14][15].…”

Section: Introductionmentioning

confidence: 99%

The orexigenic effect of melanin-concentrating hormone (MCH) is influenced by sex and stage of the estrous cycle

Santollo

Eckel

2008

Physiology & Behavior

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“…MCH was originally discovered in fish but has subsequently been identified in mammals, in whom it is thought to regulate energy balance (Pissios et al, 2006). In addition to energy balance, MCH neurotransmission has also been implicated in regulating locomotor activity (Marsh et al, 2002;Segal-Lieberman et al, 2003), and inactivation of the MCH receptor 1 leads to increased wheel running (Zhou et al, 2005). MCH neurotransmission is also thought to play a role in mediating anxiety-and depression-like behaviors in rodents (Borowsky et al, 2002).…”

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confidence: 99%

Distinct populations of presympathetic‐premotor neurons express orexin or melanin‐concentrating hormone in the rat lateral hypothalamus

Kerman

Bernard

Rosenthal

et al. 2007

J of Comparative Neurology

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Orexin and melanin-concentrating hormone (MCH) have been implicated in mediating a variety of different behaviors. These include sleep and wakefulness, locomotion, ingestive behaviors, and fight-or-flight response, as well as anxiety- and panic-like behaviors in rodents. Despite such diversity, all these processes require coordinated recruitment of the autonomic and somatomotor efferents. We have previously mapped the locations of presympathetic-premotor neurons (PSPMNs) in the rat brain. These putative dual-function neurons send trans-synaptic projections to somatomotor and sympathetic targets and likely participate in somatomotor-sympathetic integration. A significant portion of these neurons is found within the dorsomedial (DMH) and lateral hypothalamus (LH), areas of the brain that contain MCH- and orexin- synthesizing neurons in the central nervous system. Thus, we hypothesized that hypothalamic PSPMNs utilize MCH or orexin as their neurotransmitter. To test this hypothesis, we identified PSPMNs by using recombinant strains of the pseudorabies virus (PRV) for trans-synaptic tract tracing. PRV-152, a strain that expresses enhanced green fluorescent protein, was injected into sympathectomized gastrocnemius muscle, whereas PRV-BaBlu, which expresses beta-galactosidase, was injected into the adrenal gland in the same animals. By using immunofluorescent methods, we determined whether co-infected neurons express MCH or orexin. Our findings demonstrate that PSPMNs synthesizing either MCH or orexin are present within LH, where they form two separate populations. PSPMNs located around the fornix express orexin, whereas those located around the cerebral peduncle are more likely to express MCH. These two clusters of PSPMNs within LH likely play distinct functional roles in autonomic homeostasis and stress coping mechanisms.

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“…In brief, G1 represents the influence of sequence variation in genes on physical activity behavior. Family and twin studies have provided evidence for significant genetic effects on physical activity level as well as on indicators of sedentarism (4), which have been supported by molecular genetic studies in humans (5,6) and in animals (7)(8)(9)(10). G3 refers to the genetic path to fitness.…”

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confidence: 99%