Enhanced osteointegration of poly(methylmethacrylate) bone cements by incorporating strontium-containing borate bioactive glass

Abstract

Although poly(methylmethacrylate) (PMMA) cements are widely used in orthopaedics, they have numerous drawbacks. This study aimed to improve their bioactivity and osseointegration by incorporating strontium-containing borate bioactive glass (SrBG) as the reinforcement phase and bioactive filler of PMMA cement. The prepared SrBG/PMMA composite cements showed significantly decreased polymerization temperature when compared with PMMA and retained properties of appropriate setting time and high mechanical strength. The bioactivity of SrBG/PMMA composite cements was confirmed , evidenced by ion release (Ca, P, B and Sr) from SrBG particles. The cellular responses of MC3T3-E1 cells demonstrated that SrBG incorporation could promote adhesion, migration, proliferation and collagen secretion of cells. Furthermore, our investigation revealed that SrBG/PMMA composite cements presented better osseointegration than PMMA bone cement. SrBG in the composite cement could stimulate new-bone formation around the interface between the composite cement and host bone at eight and 12 weeks post-implantation, whereas PMMA bone cement only stimulated development of an intervening connective tissue layer. Consequently, the SrBG/PMMA composite cement may be a better alternative to PMMA cement in clinical applications and has promising orthopaedic applications by minimal invasive surgery.

Percutaneous Injection of Strontium Containing Hydroxyapatite versus Polymethacrylate Plus Short-Segment Pedicle Screw Fixation for Traumatic A2- and A3/AO-Type Fractures in Adults

“…Taking into consideration the extensive experience gained in clinical practice with PMMA and its low cost, efforts have been made recently to improve the bioactivity of PMMA [ 41 ]. Researchers have attempted to improve PMMA bioactivity and osseointegration by incorporating Sr-containing borate bioactive glass (SrBG) as a reinforcement phase and bioactive filler for the PMMA cement [ 41 ]. The prepared SrBG/PMMA composite cements showed evidence of significantly decreased polymerization temperatures, when compared with PMMA alone.…”

Bibliographic review on the state of the art of strontium and zinc based regenerative therapies. Recent developments and clinical applications

“…57 Bone cements are usually composed of two systems: powder (homopolymer PMMA (polymethyl methacrylate) + BPO (benzoyl peroxide)/ZrO 2 (zirconia)/BaSO 4 (barium sulphate)); and liquid (monomer MMA + hydroquinone + N,N-dimethyl para-toluidine (DMPT)). 58 Cui X. et al 59 offered an innovative proposal by fusing these two concepts: bone cements and bioactive glasses, integrating a Sr containing borate bioactive glass (SrBG) into a bone cement in several concentrations: 10SrBG, 20SrBG and 30SrBG being 0.2, 0.4 and 0.6 g of SrBG respectively and comparing the results with a non-doped PMMA cement. This experiment was carried out on the MC3T3-E1 cell line as well as in vivo, in healthy and osteoporotic Sprague-Dawley rats.…”

Mechanical and degradation properties of poly(methyl methacrylate) cement/borate bioactive glass composites

“…While bioactive glasses have been previously added to chitosan paste and other scaffold materials, there have been very few reported attempts to form composites of bioactive glasses and PMMA bone cements (Cui et al, , ; Rahaman, Bal, & Huang, ). Two previous studies added silicate‐based bioactive glasses to acrylic bone cement and then tested the composite's improved bone‐binding ability and mechanical properties (Shinzato et al, ; Shinzato et al, ).…”