Enhanced endothelial cell activity induced by incorporation of nano-thick tantalum layer in artificial vascular grafts

Park, Cheonil; Park, Suhyung; Kim, Jin‐Young; Han, Ahram; Ahn, Sungyoon; Min, Sang Il; Jae, Hwan Jun; Chung, Jin Wook; Lee, Jong Ho; Jung, Hyun‐Do; Kim, Hyoun Ee; Jang, Tae‐Sik

doi:10.1016/j.apsusc.2019.144801

Cited by 23 publications

(21 citation statements)

References 42 publications

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“…The Zr-14Nb-5Ta-1Mo alloy showed an improved balance of mechanical properties with low magnetic susceptibility (16.96×10 −9 m 3 kg −1 ) and Young's modulus (61 GPa) 27) , which strongly implies its potential application as implants. Although the safety or promotion of osteogenic differentiation in vitro for each additional element, niobium 36,37) , tantalum 38) , and molybdenum 39,40) , respectively, has been reported, the lack of detailed information about the cytocompatibility and osteoconductivity of Zr-14Nb-5Ta-1Mo alloy limits its dental and medical applications.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of cytocompatibility and osteoconductivity of Zr-14Nb-5Ta-1Mo alloy with MC3T3-E1 cells

et al. 2022

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The cytocompatibility and osteoconductivity of the Zr-14Nb-5Ta-1Mo alloy were investigated using a mouse osteoblastic cell line (MC3T3-E1) to promote the application of this newly developed alloy in dental/medical treatment. The initial cell-attached morphology was visualized by fluorescent staining, and cells cultured on the Zr alloy showed similar cell adhesion behavior to cells cultured on titanium (Ti). In our 5-day proliferation investigation, similar cell numbers were obtained with both Zr alloy and Ti. These results indicate that the cytocompatibility of Zr alloy is similar to that of Ti. In addition, the similar results in the evaluation of alkaline phosphatase (ALP) activity and staining of deposited calcium using alizarin red S with both Zr alloy and Ti indicated that the osteoconductivity of the Zr alloy is similar to that of Ti. Our results prove the good cytocompatibility and osteoconductivity of the Zr-14Nb-5Ta-1Mo alloy, enabling its promotion for use in dental/medical applications.

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Section: Discussionmentioning

confidence: 99%

Evaluation of cytocompatibility and osteoconductivity of Zr-14Nb-5Ta-1Mo alloy with MC3T3-E1 cells

et al. 2022

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“…Bilayered nanofibrous vascular constructs with improved mechanical properties and bioactivity were also produced by the electrospinning technique. 6 The electrospun structure was composed of a randomly oriented PCL/silica outer layer for enhanced mechanical properties and fibroblast affinity, and a longitudinally aligned PLC/collagen inner layer for promoted endothelial cell adherence and rapid migration. The fabricated bilayer vascular constructs showed higher tensile properties in terms of the longitudinal and circumferential directions, than those of the human coronary artery.…”

Section: Conventional Strategy For Developing Vascular Constructsmentioning

confidence: 99%

“…Artificial grafts consisting of polymeric matrices such as poly(ε-caprolactone) (PCL), expanded form of PTFE (ePTFE), and polyurethane (PU), exhibited successful results in vascular applications. 6 – 8 In addition, vascular stents made from synthetic polymers and metallic materials with various surface modifications showed their effectiveness by in vitro and in vivo examinations in recent articles. 6 , 9 – 14 However, there have been needs for creating artificial vascular grafts with customized structures to meet versatile structure of each patients and each surgical sites.…”

Section: Introductionmentioning

confidence: 99%

“… 6 – 8 In addition, vascular stents made from synthetic polymers and metallic materials with various surface modifications showed their effectiveness by in vitro and in vivo examinations in recent articles. 6 , 9 – 14 However, there have been needs for creating artificial vascular grafts with customized structures to meet versatile structure of each patients and each surgical sites.…”

Section: Introductionmentioning

confidence: 99%

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Freeform 3D printing of vascularized tissues: Challenges and strategies

et al. 2021

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In recent years, freeform three-dimensional (3D) printing has led to significant advances in the fabrication of artificial tissues with vascularized structures. This technique utilizes a supporting matrix that holds the extruded printing ink and ensures shape maintenance of the printed 3D constructs within the prescribed spatial precision. Since the printing nozzle can be translated omnidirectionally within the supporting matrix, freeform 3D printing is potentially applicable for the fabrication of complex 3D objects, incorporating curved, and irregular shaped vascular networks. To optimize freeform 3D printing quality and performance, the rheological properties of the printing ink and supporting matrix, and the material matching between them are of paramount importance. In this review, we shall compare conventional 3D printing and freeform 3D printing technologies for the fabrication of vascular constructs, and critically discuss their working principles and their advantages and disadvantages. We also provide the detailed material information of emerging printing inks and supporting matrices in recent freeform 3D printing studies. The accompanying challenges are further discussed, aiming to guide freeform 3D printing by the effective design and selection of the most appropriate materials/processes for the development of full-scale functional vascularized artificial tissues.

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“…Bio-lubrication uses lubrication theory and methods for friction pairs in biological systems. It studies the tribological problems of biological systems or external surfaces of biological systems including the friction between human body replacement joints and biological tissues [120][121][122], the adhesion of blood on artificial implant [123,124], tooth wear [125][126][127], and skin friction [128,129].…”

Section: Application Of Go In Bio-lubricationmentioning

confidence: 99%

Water lubrication of graphene oxide-based materials

Xue

Guo

et al. 2021

Friction

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Water is as an economic, eco-friendly, and efficient lubricant that has gained widespread attention for manufacturing. Using graphene oxide (GO)-based materials can improve the lubricant efficacy of water lubrication due to their outstanding mechanical properties, water dispersibility, and broad application scenarios. In this review, we offer a brief introduction about the background of water lubrication and GO. Subsequently, the synthesis, structure, and lubrication theory of GO are analyzed. Particular attention is focused on the relationship between pH, concentration, and lubrication efficacy when discussing the tribology behaviors of pristine GO. By compounding or reacting GO with various modifiers, amounts of GO-composites are synthesized and applied as lubricant additives or into frictional pairs for different usage scenarios. These various strategies of GO-composite generate interesting effects on the tribology behaviors. Several application cases of GO-based materials are described in water lubrication, including metal processing and bio-lubrication. The advantages and drawbacks of GO-composites are then discussed. The development of GO-based materials for water lubrication is described including some challenges.

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Enhanced endothelial cell activity induced by incorporation of nano-thick tantalum layer in artificial vascular grafts

Cited by 23 publications

References 42 publications

Evaluation of cytocompatibility and osteoconductivity of Zr-14Nb-5Ta-1Mo alloy with MC3T3-E1 cells

Evaluation of cytocompatibility and osteoconductivity of Zr-14Nb-5Ta-1Mo alloy with MC3T3-E1 cells

Freeform 3D printing of vascularized tissues: Challenges and strategies

Water lubrication of graphene oxide-based materials

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