Indole-3-carbinol (13C) is a secondary plant metabolite produced in vegetables of the Brassica genus, including cabbage, cauliflower, and brussels sprouts. I3C is both an anti-initiator and a promoter of carcinogenesis. Consumption of 13C by humans and rodents can lead to marked increases in activities ofcytochrome P-450-dependent monooxygenases and in a variety ofphase II drug-metabolizing enzymes. We have reported previously that the enzyme-inducing activity of 13C is mediated through a mechanism requiring exposure of the compound to the low-pH environment of the stomach. We report here the aromatic hydrocarbon responsiveness-receptor Kd values (22 nM-90 nM), determined with C57BL/6J mouse liver cytosol and the in vitro-and in vivo-molar yields (0.1-6%) of the major acid condensation products of 13C. We also show that indolo[3,2-b]carbazole (ICZ) is produced from 13C in yields on the order of 0.01% in vitro and, after oral intubation, in vivo. ICZ has a Kd of 190 pM for aromatic hydrocarbon responsiveness-receptor binding and an EC50 of 269 nM for induction of cytochrome P4501A1, as measured by ethoxyresorufm O-deethylase activity in murine hepatoma Hepa lclc7 cells. The binding affinity of ICZ is only a factor of 3.7 X 10-2 lower than that of the highly toxic environmental contaminant and cancer promoter 2,3,7,8-tetrachlorodibenzo-p-dioxin. ICZ and related condensation products appear responsible for the enzyme-inducing effects of dietary 13C.

Online learning is an educational process which takes place over the Internet as a form of distance education. Distance education became ubiquitous as a result of the COVID-19 pandemic during 2020. Because of these circumstances, online teaching and learning had an indispensable role in early childhood education programs, even though debates continue on whether or not it is beneficial for young children to be exposed extensively to Information and Communication Technology (ICT). This descriptive study demonstrates how a preservice teacher education course in early childhood education was redesigned to provide student teachers with opportunities to learn and teach online. It reports experiences and reflections from a practicum course offered in the Spring Semester of 2020, in the USA. It describes three phases of the online student teachers' experiences-Preparation, Implementation, and Reflection. Tasks accomplished in each phase are reported. Online teaching experiences provided these preservice teachers with opportunities to interact with children, as well as to encourage reflection on how best to promote young children's development and learning with online communication tools.

Flexible pressure sensors with a high sensitivity over a broad linear range can simplify wearable sensing systems without additional signal processing for the linear output, enabling device miniaturization and low power consumption. Here, we demonstrate a flexible ferroelectric sensor with ultrahigh pressure sensitivity and linear response over an exceptionally broad pressure range based on the material and structural design of ferroelectric composites with a multilayer interlocked microdome geometry. Due to the stress concentration between interlocked microdome arrays and increased contact area in the multilayer design, the flexible ferroelectric sensors could perceive static/dynamic pressure with high sensitivity (47.7 kPa, 1.3 Pa minimum detection). In addition, efficient stress distribution between stacked multilayers enables linear sensing over exceptionally broad pressure range (0.0013-353 kPa) with fast response time (20 ms) and high reliability over 5000 repetitive cycles even at an extremely high pressure of 272 kPa. Our sensor can be used to monitor diverse stimuli from a low to a high pressure range including weak gas flow, acoustic sound, wrist pulse pressure, respiration, and foot pressure with a single device.

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Hybrid films composed of reduced graphene oxide (RG-O) and Cu nanowires (NWs) were prepared. Compared to Cu NW films, the RG-O/Cu NW hybrid films have improved electrical conductivity, oxidation resistance, substrate adhesion, and stability in harsh environments. The RG-O/Cu NW films were used as transparent electrodes in Prussian blue (PB)-based electrochromic devices where they performed significantly better than pure Cu NW films.

Electronic skin (e-skin) technology is an exciting frontier to drive the next generation of wearable electronics owing to its high level of wearability, enabling high accuracy to harvest information of users and their surroundings. Recently, biomimicry of human and biological skins has become a great inspiration for realizing novel wearable electronic systems with exceptional multifunctionality as well as advanced sensory functions. This review covers and highlights bioinspired e-skins mimicking perceptive features of human and biological skins. In particular, five main components in tactile sensation processes of human skin are individually discussed with recent advances of e-skins that mimic the unique sensing mechanisms of human skin. In addition, diverse functionalities in user-interactive, skinattachable, and ultrasensitive e-skins are introduced with the inspiration from unique architectures and functionalities, such as visual expression of stimuli, reversible adhesion, easy deformability, and camouflage, in biological skins of natural creatures. Furthermore, emerging wearable sensor systems using bioinspired e-skins for body motion tracking, healthcare monitoring, and prosthesis are described. Finally, several challenges that should be considered for the realization of next-generation skin electronics are discussed with recent outcomes for addressing these challenges.

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Rationale: Symptom subtypes have been described in clinical and population samples of patients with obstructive sleep apnea (OSA). It is unclear whether these subtypes have different cardiovascular consequences. Objectives: To characterize OSA symptom subtypes and assess their association with prevalent and incident cardiovascular disease in the Sleep Heart Health Study. Methods: Data from 1,207 patients with OSA (apnea-hypopnea index > 15 events/h) were used to evaluate the existence of symptom subtypes using latent class analysis. Associations between subtypes and prevalence of overall cardiovascular disease and its components (coronary heart disease, heart failure, and stroke) were assessed using logistic regression. Kaplan-Meier survival analysis and Cox proportional hazards models were used to evaluate whether subtypes were associated with incident events, including cardiovascular mortality. Measurements and Main Results: Four symptom subtypes were identified (disturbed sleep [12.2%], minimally symptomatic [32.6%], excessively sleepy [16.7%], and moderately sleepy [38.5%]), similar to prior studies. In adjusted models, although no significant associations with prevalent cardiovascular disease were found, the excessively sleepy subtype was associated with more than threefold increased risk of prevalent heart failure compared with each of the other subtypes. Symptom subtype was also associated with incident cardiovascular disease (P , 0.001), coronary heart disease (P = 0.015), and heart failure (P = 0.018), with the excessively sleepy again demonstrating increased risk (hazard ratios, 1.7-2.4) compared with other subtypes. When compared with individuals without OSA (apnea-hypopnea index , 5), significantly increased risk for prevalent and incident cardiovascular events was observed mostly for patients in the excessively sleepy subtype. Conclusions: OSA symptom subtypes are reproducible and associated with cardiovascular risk, providing important evidence of their clinical relevance.