Enhanced effect in combination of curcumin- and ketoconazole-loaded methoxy poly (ethylene glycol)-poly (ε-caprolactone) micelles

Teng, Fangfang; Deng, Peizong; Song, Zhen; Zhou, Feilong; Feng, Runliang

doi:10.1016/j.biopha.2017.01.033

Cited by 15 publications

(5 citation statements)

References 47 publications

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“…On the other hand, as reported in the review by Kashef et al [377], polymeric micelles are easier to produce, hence they are more cost-efficient than liposomes and potentially polymersomes, while providing similar applicable features [378,379]. Among examples, an aPDT system of polymeric micelles, fabricated from methoxy-PEG and PCL and loaded with the hydrophobic PS curcumin and ketoconazole for the PDI of fungal biofilms, has been reported with an increased water solubility and controlled release of the PSs on display [380]. Additionally, Caruso et al recently reported the synthesis of thermodynamically stable PEG-PLA micelles for efficient aPDI of S. aureus, suggesting that this delivery system is promising in aPDI applications, which also reduces toxicity compared with pure PSs [291].…”

Section: Polymeric Micellesmentioning

confidence: 96%

Antimicrobial Photodynamic Therapy: Latest Developments with a Focus on Combinatory Strategies

et al. 2021

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Antimicrobial photodynamic therapy (aPDT) has become a fundamental tool in modern therapeutics, notably due to the expanding versatility of photosensitizers (PSs) and the numerous possibilities to combine aPDT with other antimicrobial treatments to combat localized infections. After revisiting the basic principles of aPDT, this review first highlights the current state of the art of curative or preventive aPDT applications with relevant clinical trials. In addition, the most recent developments in photochemistry and photophysics as well as advanced carrier systems in the context of aPDT are provided, with a focus on the latest generations of efficient and versatile PSs and the progress towards hybrid-multicomponent systems. In particular, deeper insight into combinatory aPDT approaches is afforded, involving non-radiative or other light-based modalities. Selected aPDT perspectives are outlined, pointing out new strategies to target and treat microorganisms. Finally, the review works out the evolution of the conceptually simple PDT methodology towards a much more sophisticated, integrated, and innovative technology as an important element of potent antimicrobial strategies.

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Section: Polymeric Micellesmentioning

confidence: 96%

Antimicrobial Photodynamic Therapy: Latest Developments with a Focus on Combinatory Strategies

et al. 2021

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“…Higher inhibition zones were observed for samples incubated with micelles containing both drugs (KCZ-CUR-M), but the method used to encapsulate both drugs on micelles was not reported. The effect of micelles on 48 h biofilms showed reductions in fungal viability of 2.66% and 17.7% after incubation for 48 h with KCZ-M and CKZ-CUR-M. Confocal microscopic images showed the strongest disruption in biofilms treated with the combination of CUR-M and KCZ-M [95].…”

Section: Cur In Micellesmentioning

confidence: 99%

“…The association of CUR in micelles with a commercial antifungal agent (ketoconazole, KCZ) was reported against C. albicans [95]. CUR in PEG-PCL micelles (CUR-M) at 256 µg/mL was required to inhibit fungal growth by eighty percent (MIC80).…”

Section: Cur In Micellesmentioning

confidence: 99%

Antimicrobial Activity of Curcumin in Nanoformulations: A Comprehensive Review

Trigo-Gutierrez

Vega-Chacón

Soares

et al. 2021

IJMS

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Curcumin (CUR) is a natural substance extracted from turmeric that has antimicrobial properties. Due to its ability to absorb light in the blue spectrum, CUR is also used as a photosensitizer (PS) in antimicrobial Photodynamic Therapy (aPDT). However, CUR is hydrophobic, unstable in solutions, and has low bioavailability, which hinders its clinical use. To circumvent these drawbacks, drug delivery systems (DDSs) have been used. In this review, we summarize the DDSs used to carry CUR and their antimicrobial effect against viruses, bacteria, and fungi, including drug-resistant strains and emergent pathogens such as SARS-CoV-2. The reviewed DDSs include colloidal (micelles, liposomes, nanoemulsions, cyclodextrins, chitosan, and other polymeric nanoparticles), metallic, and mesoporous particles, as well as graphene, quantum dots, and hybrid nanosystems such as films and hydrogels. Free (non-encapsulated) CUR and CUR loaded in DDSs have a broad-spectrum antimicrobial action when used alone or as a PS in aPDT. They also show low cytotoxicity, in vivo biocompatibility, and improved wound healing. Although there are several in vitro and some in vivo investigations describing the nanotechnological aspects and the potential antimicrobial application of CUR-loaded DDSs, clinical trials are not reported and further studies should translate this evidence to the clinical scenarios of infections.

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“…KTZ is a lipophilic drug, synthetic derivative of phenylpiperazine, with antifungal properties and potential antineoplastic activity (25). Its antifungal action allows to inhibit the growth of dermatophytes, such as Trichophyton, Microsporum and Epidermophyton, as well as more common yeasts, such as Candida albicans (26). In this way, KTZ is widely used for the treatment of fungal infections, especially against thrush, gastrointestinal infections, and infections of the skin, nails, and scalp (25,27).…”

Section: Introductionmentioning

confidence: 99%

Waterborne poly(urethane-urea)s films as a sustained release system for ketoconazole

et al. 2019

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Ketoconazole (KTZ) was incorporated in waterborne poly(urethane-urea)s dispersions (WPUU), aiming at the production of films for drug sustained release. Dispersions based on poly(ethylene glycol-block-propylene glycol) (PEG-b-PPG) (four monomers with different contents of PEG hydrophilic segments), poly(propylene glycol), isophorone diisocyanate, dime-thylolpropionic acid and hydrazine were produced and characterized by apparent viscosity and average particle size (APS). Cast films-drug interaction was investigated by Fourier-Transform infrared spectrometry (FTIR). In vitro dissolution assays were performed in simulated gastrointestinal juices, followed by application of kinetic models. Stable pseudoplastic dispersions, with APS between 27 to 320 nm were obtained. FTIR from KTZ-loaded films indicated interactions between polymer and drug. In vitro release of KTZ was achieved above 80%, notably influenced by PEG-based segments content up to 2 h, followed by sustained release for 8 h. Higuchi’s and first-order equations described the drug kinetic profile, as diffusion of the drug and erosion of the swollen polymer, respectively.

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Enhanced effect in combination of curcumin- and ketoconazole-loaded methoxy poly (ethylene glycol)-poly (ε-caprolactone) micelles

Cited by 15 publications

References 47 publications

Antimicrobial Photodynamic Therapy: Latest Developments with a Focus on Combinatory Strategies

Antimicrobial Photodynamic Therapy: Latest Developments with a Focus on Combinatory Strategies

Antimicrobial Activity of Curcumin in Nanoformulations: A Comprehensive Review

Waterborne poly(urethane-urea)s films as a sustained release system for ketoconazole

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