Waterborne poly(urethane-urea)s films as a sustained release system for ketoconazole

Abstract

Ketoconazole (KTZ) was incorporated in waterborne poly(urethane-urea)s dispersions (WPUU), aiming at the production of films for drug sustained release. Dispersions based on poly(ethylene glycol-block-propylene glycol) (PEG-b-PPG) (four monomers with different contents of PEG hydrophilic segments), poly(propylene glycol), isophorone diisocyanate, dime-thylolpropionic acid and hydrazine were produced and characterized by apparent viscosity and average particle size (APS). Cast films-drug interaction was investigated by Fourier-Transform infrared spectrometry (FTIR). In vitro dissolution assays were performed in simulated gastrointestinal juices, followed by application of kinetic models. Stable pseudoplastic dispersions, with APS between 27 to 320 nm were obtained. FTIR from KTZ-loaded films indicated interactions between polymer and drug. In vitro release of KTZ was achieved above 80%, notably influenced by PEG-based segments content up to 2 h, followed by sustained release for 8 h. Higuchi’s and first-order equations described the drug kinetic profile, as diffusion of the drug and erosion of the swollen polymer, respectively.

In Vitro, Ex Vivo, Penetration (EpiDermTM) and in Vivo Dermatokinetics of Ketoconazole Loaded Solid Lipid Nanoparticles for Topical Delivery

“…In KOF1, few characteristic peaks of the drug (2962-2836 cm −1 assigned for C-H stretching, 1652 cm −1 for C=O stretching vibration), lipid (14898-1553 cm −1 ) and other excipients were retained with slight variation in intensities. Few peaks of the drug (for C-N and C-Cl) were overlapped with the lipid [22]. This re ected compatibility of the drug with the excipients present in the formulation.…”

Ketoconazole-loading strategy to improve antifungal activity and overcome cytotoxicity on human renal proximal tubular epithelial cells

“…The band at 1750 cm −1 belongs to the C=O stretching vibration of the ester bond, the bands at 1166 and 1086 cm −1 belong to the C-O stretch, and these bands are the characteristic peaks of the PLGA molecule. The KTZ showed the characteristic peaks of C=O stretching vibration of the carbonyl group, C=C aromatic stretching, tertiary amine groups, and C-Cl stretching at 1647 cm −1 , 1510 cm −1 , 1244 cm −1 , and 814 cm −1 respectively [46,47]. However, the significant decrease in the intensity of the main peaks of KTZ in the spectrum of KTZ-NPs and the predominance of characteristic peaks of PLGA indicate that KTZ is encapsulated into PLGA nanoparticles.…”

A comprehensive review on performance and machinability of plant fiber polymer composites

“…Well-established eco-effective resins are polyethylene glycol, polyurethane-urea, polyethylene oxide, and polyurethane. [97,98] These ecological resins are generally collected from bio-preparation methods. The eco-effective resins are encouraging components for a range of biomedical applications, coatings, adhesives, drug delivery, and membranes.…”