Antimicrobial Photodynamic Therapy: Latest Developments with a Focus on Combinatory Strategies

Youf, Raphaëlle; Müller, Max; Balasini, Ali; Thétiot, Franck; Müller, Mareike; Hascoët, Alizé; Jonas, Ulrich; Schönherr, Holger; Lemercier, Gilles; Montier, Tristan; Gall, Tony Le

doi:10.3390/pharmaceutics13121995

Cited by 68 publications

(69 citation statements)

References 493 publications

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“…In this sense, antimicrobial photodynamic inactivation (PDI) has been projected as a promising therapy to eradicate pathogens [ 12 ]. This approach is founded on the addition of a photosensitizer (PS) that binds selectively to microbial cells.…”

Section: Introductionmentioning

confidence: 99%

“…These characteristics limit the complete application of these PSs in PDI. Therefore, the substitution in the periphery of the macrocycle by groups that allows for the improvement of the interaction with biological media is a promising alternative for medical applications [ 12 , 19 ]. Another possibility is to obtain conjugated polymers formed by repeating porphyrin units [ 20 , 21 ].…”

Section: Introductionmentioning

confidence: 99%

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Antimicrobial Photosensitizing Material Based on Conjugated Zn(II) Porphyrins

et al. 2022

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The widespread use of antibiotics has led to a considerable increase in the resistance of microorganisms to these agents. Consequently, it is imminent to establish new strategies to combat pathogens. An alternative involves the development of photoactive polymers that represent an interesting strategy to kill microbes and maintain aseptic surfaces. In this sense, a conjugated polymer (PZnTEP) based on Zn(II) 5,10,15,20-tetrakis-[4-(ethynyl)phenyl]porphyrin (ZnTEP) was obtained by the homocoupling reaction of terminal alkyne groups. PZnTEP exhibits a microporous structure with high surface areas allowing better interaction with bacteria. The UV-visible absorption spectra show the Soret and Q bands of PZnTEP red-shifted by about 18 nm compared to those of the monomer. Also, the conjugate presents the two red emission bands, characteristic of porphyrins. This polymer was able to produce singlet molecular oxygen and superoxide radical anion in the presence of NADH. Photocytotoxic activity sensitized by PZnTEP was investigated in bacterial suspensions. No viable Staphylococcus aureus cells were detected using 0.5 µM PZnTEP and 15 min irradiation. Under these conditions, complete photoinactivation of Escherichia coli was observed in the presence of 100 mM KI. Likewise, no survival was detected for E. coli incubated with 1.0 µM PZnTEP after 30 min irradiation. Furthermore, polylactic acid surfaces coated with PZnTEP were able to kill efficiently these bacteria. This surface can be reused for at least three photoinactivation cycles. Therefore, this conjugated photodynamic polymer is an interesting antimicrobial photoactive material for designing and developing self-sterilizing surfaces.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Antimicrobial Photosensitizing Material Based on Conjugated Zn(II) Porphyrins

et al. 2022

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“…PDT has been used in combination with several non-invasive therapeutic approaches with additive and synergistic efficacy and enhancement of outcomes in most studies conducted in vitro, as well as in preclinical and clinical applications [ 71 ]. In this regard, studies and applications have been reported for aPDT in combination with antibiotic chemotherapy [ 72 ] PTT [ 73 ], MHT [ 74 ], CAP [ 75 , 76 ], and endodontic debridement [ 77 ].…”

Section: Combination Therapies With Antimicrobial Photodynamic Therapymentioning

confidence: 99%

Applications of Antimicrobial Photodynamic Therapy against Bacterial Biofilms

Songca

Adjei

2022

IJMS

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Antimicrobial photodynamic therapy and allied photodynamic antimicrobial chemotherapy have shown remarkable activity against bacterial pathogens in both planktonic and biofilm forms. There has been little or no resistance development against antimicrobial photodynamic therapy. Furthermore, recent developments in therapies that involve antimicrobial photodynamic therapy in combination with photothermal hyperthermia therapy, magnetic hyperthermia therapy, antibiotic chemotherapy and cold atmospheric pressure plasma therapy have shown additive and synergistic enhancement of its efficacy. This paper reviews applications of antimicrobial photodynamic therapy and non-invasive combination therapies often used with it, including sonodynamic therapy and nanozyme enhanced photodynamic therapy. The antimicrobial and antibiofilm mechanisms are discussed. This review proposes that these technologies have a great potential to overcome the bacterial resistance associated with bacterial biofilm formation.

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“…Also, the self-aggregation of PS in an aqueous medium may decrease the efficacy of PDT treatment. This issue leads to the lower production of ROS [ 9 , 10 ]. In this regard, various nanotechnology platforms have been developed to overcome these limitations [ 11 – 13 ].…”

Section: Introductionmentioning

confidence: 99%

The application of selenium nanoparticles for enhancing the efficacy of photodynamic inactivation of planktonic communities and the biofilm of Streptococcus mutans

et al. 2022

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Objective Streptococcus mutans is one of the principal causative agents of dental caries (tooth decay) found in the oral cavity. Therefore, this study investigates whether selenium nanoparticles (SeNPs) enhance the efficacy of photodynamic therapy (PDT) against both planktonic communities and the one-day-old biofilm of S. mutans. In this study, the planktonic and 24-h biofilm of S. mutans have been prepared in 96-cell microplates. These forms were treated by methylene blue (MB) and SeNPs and then were exposed to light-emitting diode (LED) lighting. Finally, the results have been reported as CFU/ml. Results The outcomes demonstrated that MB-induced PDT and SeNPs significantly reduced the number of planktonic bacteria (P-value < 0.001). The comparison between the treated and untreated groups showed that combining therapy with SeNPs and PDT remarkably decreased colony-forming units of one-day-old S. mutans biofilm (P-value < 0.05). The findings revealed that PDT modified by SeNPs had a high potential to destroy S. mutans biofilm. This combination therapy showed promising results to overcome oral infection in dental science.

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Antimicrobial Photodynamic Therapy: Latest Developments with a Focus on Combinatory Strategies

Cited by 68 publications

References 493 publications

Antimicrobial Photosensitizing Material Based on Conjugated Zn(II) Porphyrins

Antimicrobial Photosensitizing Material Based on Conjugated Zn(II) Porphyrins

Applications of Antimicrobial Photodynamic Therapy against Bacterial Biofilms

The application of selenium nanoparticles for enhancing the efficacy of photodynamic inactivation of planktonic communities and the biofilm of Streptococcus mutans

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