Enhanced anticancer potency with reduced nephrotoxicity of newly synthesized platin-based complexes compared with cisplatin

Salehi, Roya; Abyar, Selda; Ramazani, Fatemeh; Khandar, Ali Akbar; Hosseini‐Yazdi, Seyed Abolfazl; White, Jonathan M.; Edalati, Mahdi; Kahroba, Houman; Talebi, Mehdi

doi:10.1038/s41598-022-11904-3

Cited by 13 publications

(9 citation statements)

References 33 publications

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“…Flow cytometry findings show the effects of different formulations on cell cycle progression in HT-29 cells ( Figure 8 ). The Sub-G0/G1 area is of special interest in many toxicity studies that show the characteristics of apoptosis [ 32 , 33 , 34 ]. HT-29 cells that received radiation therapy only showed Sub-G0/G1 (21.5% in 2 Gy and 42.9% in 6 Gy), which is more dominant in 6 Gy radiation-treated groups.…”

Section: Discussionmentioning

confidence: 99%

Assessment of Oxaliplatin-Loaded Iodine Nanoparticles for Chemoradiotherapy of Human Colorectal Cancer (HT-29) Cells

et al. 2022

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Colorectal cancer is highly prevalent worldwide and has significant morbidity and mortality in humans. High-atomic-number nanoparticles such as iodine can act as X-rays absorbers to increase the local dose. The synthesis and fabrication of oxaliplatin-loaded iodine nanoparticles, their characterization, cell toxicity, radiosensitivity, cell apoptosis, and cell cycle assay in human colorectal cancer (HT-29) cells are investigated. Results show that the synthesis of a new iodine nanoparticle, polymerized triiodobenzene coated with chitosan and combined with oxaliplatin as a chemotherapeutic drug, performed well in vitro in an intracellular radiosensitizer as chemoradiotherapy agent in HT-29 cell lines. Findings also show that the INPs alone have no impact on cell cycle development and apoptosis. In contrast, oxaliplatin-loaded INPs along with 2 and 6 MV radiation doses produced more apoptosis. The interaction of INPs with mega-voltage photon energies is the cause of a major radiosensitization enhancement in comparison to radiation alone. Furthermore, results show that INPs may work as radiosensitization nanoprobe agents in the treatment of HT-29 cells due to their effect on increasing radiation dose absorption. Overall, iodine nanoparticles may be used in the treatment of colorectal cancers in clinical studies.

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Section: Discussionmentioning

confidence: 99%

Assessment of Oxaliplatin-Loaded Iodine Nanoparticles for Chemoradiotherapy of Human Colorectal Cancer (HT-29) Cells

et al. 2022

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“…Complex 89 is a Pt (II) complex with α-n heterocyclic thiosemicarbazide as ligand, with an IC 50 value of 79 ± 4 μM for the A549 cell line after 72 h of incubation ( Scheme 9 ) ( Matesanz et al, 2018 ). The IC 50 values of complex 90 against the A549 cell line were 146.6, 101.7 and 69.28, respectively, after 24, 48 and 72 h of treatment ( Scheme 9 ) ( Salehi et al, 2022 ).…”

Section: Thiosemicarbazone Platinum (Ii) Gold (I) and Silver (I) Comp...mentioning

confidence: 99%

Advances in thiosemicarbazone metal complexes as anti-lung cancer agents

Bai

Zheng²,

Qi³

2022

Front. Pharmacol.

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The great success of cisplatin as a chemotherapeutic agent considerably increased research efforts in inorganic biochemistry to identify more metallic drugs having the potential of treating lung cancer. Metal coordination centres, which exhibit a wide range of coordination numbers and geometries, various oxidised and reduced states and the inherent ligand properties offer pharmaceutical chemists a plethora of drug structures. Owing to the presence of C=N and C=S bonds in a thiosemicarbazone Schiff base, N and S atoms in its hybrid orbital has lone pair of electrons, which can generate metal complexes with different stabilities with most metal elements under certain conditions. Such ligands and complexes play key roles in the treatment of anti-lung cancer. Research regarding metallic anti-lung cancer has advanced considerably, but there remain several challenges. In this review, we discuss the potential of thiosemicarbazone Schiff base complexes as anti-lung cancer drugs, their anti-cancer activities and the most likely action mechanisms involving the recent families of copper, nickel, platinum, ruthenium and other complexes.

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“…At approximately 92 h of incubation, cisplatin at concentrations 1, 10, 20, 50, and 120 μM were added to cells, in triplicates. These concentrations were selected with based on the IC 50 values of secondary lung cancer cell lines such as A549 from literature [16][17][18]. The range was widened to avoid any missing points for the IC 50 determination.…”

Section: In-vitro Cytotoxicity Of Cisplatin On Primary Lung Cancer Ce...mentioning

confidence: 99%

Application of Real-Time Cell Analysis Biosensor Technology for Drug Cytotoxicity Studies in Primary Lung Cancer Cells

Mansor

Sedek

Nordin

et al. 2022

Biomedical Materials & Devices

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Biosensing technologies can be used for toxicity studies on cell cultures. The xCELLigence Real-Time Cell Analysis (RTCA) system is a portable label-free detection method with the capability to analyze cellular proliferation, migration, invasion, growth, morphology states, and cytotoxicity of adherent cells in a non-invasive environment. In pharmacological context, most xCELLigence studies were done using cancer cell lines. Hypothetically, implementing the system with primary cell culture can anticipate actions in vivo better than those seen on cell lines. This could potentially provide useful information on how the drug responds to targeted cancer. In this work, we explore the usage of biosensing technology to establish a concept for high-throughput testing of chemotherapeutics agents on primary patient-derived cancer cells. Four self-established primary lung cancer cells (samples A36, A38, A39, and A40) were derived from biopsies of patients, cultured, and tested with cisplatin. The xCELLigence was used to monitor the response of primary lung cancer cells toward different concentrations of cisplatin ranging from 1 to 120 μM. Cisplatin was found to be effective at approximately 20 μM after 48 h of exposure with A38 and A39 showing drug resistance behavior at below 20 μM concentration. The IC 50 values were between 22.88 to 76.22 μM. This indicates that the RTCA biosensor technology has good potential in predicting the cell's response to chemotherapy especially when primary cancer cells are used. This approach can be the fundamental reference in the future to support personalized chemotherapy treatment by providing additional information on metastatic behavior, cytotoxic and drug-resistance effects of the cancer cells.

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Enhanced anticancer potency with reduced nephrotoxicity of newly synthesized platin-based complexes compared with cisplatin

Cited by 13 publications

References 33 publications

Assessment of Oxaliplatin-Loaded Iodine Nanoparticles for Chemoradiotherapy of Human Colorectal Cancer (HT-29) Cells

Assessment of Oxaliplatin-Loaded Iodine Nanoparticles for Chemoradiotherapy of Human Colorectal Cancer (HT-29) Cells

Advances in thiosemicarbazone metal complexes as anti-lung cancer agents

Application of Real-Time Cell Analysis Biosensor Technology for Drug Cytotoxicity Studies in Primary Lung Cancer Cells

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