Engineering three-dimensional cell mechanical microenvironment with hydrogels

Huang, Guangsu; Wang, Lin; Wang, Shuqi; Han, Yu; Wu, Jinhui; Zhang, Qiancheng; Xu, Feng; Lu, Tian Jian

doi:10.1088/1758-5082/4/4/042001

Cited by 157 publications

(126 citation statements)

References 116 publications

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“…Both the gross scaffold structure and its internal architecture affect the behavior and viability of the cells seeded inside. These properties facilitate cell attachment, proliferation and differentiation within the entire scaffold to organize the cells in a tissue-like manner [20]. In the last few decades, hydrogels have been adopted as standard ECM substitutes due to their biocompatibility, degradability, exceptional oxygen and nutrient permeability [21e24] and structural stability [25].…”

Section: Introductionmentioning

confidence: 99%

3D printing of layered brain-like structures using peptide modified gellan gum substrates

et al. 2015

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Section: Introductionmentioning

confidence: 99%

3D printing of layered brain-like structures using peptide modified gellan gum substrates

et al. 2015

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“…By using this technique, several avascular tissues such as bladder [54] and skin [55] have been engineered effectively. However, due to the limited diffusion properties of these scaffolds, this technique faces several challenges for fabrication of more complex tissues such as heart and liver [56]. Therefore, "bottom-up" methods have been developed to overcome this problem [57].…”

Section: Manufacturing Of Scaffolds With 3-d Printing Technologymentioning

confidence: 99%

Application of 3-D Printing for Tissue Regeneration in Oral and Maxillofacial Surgery: What is Upcoming?

Keyhan¹,

Fallahi²,

Jahangirnia³

et al. 2018

Biomaterials in Regenerative Medicine

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The ultimate goal of any surgical procedure is to improve perioperative form and function and to minimize operative and postoperative morbidity. In recent years, many exciting and novel technological advances have been introduced in the field of oral and maxillofacial surgery. One example of such technology that is continuing to increase in prevalence is the use of 3-dimensional (3-D) printing techniques with special properties, which seems hopeful for practitioners in the field of regenerative medicine. Tissue engineering is a critical and important area in biomedical engineering for creating biological alternatives for grafts, implants, and prostheses. One of the main triad bases for tissue engineering is scaffolds, which play a great role for determining growth directions of stem cells in a 3-dimensional aspect. Mechanical strength of these scaffolds is critical as well as interconnected channels and controlled porosity or pores distribution. However, existing 3-D scaffolds proved less than ideal for actual clinical applications. In this chapter, we review the application and advancement of rapid prototyping (RP) techniques in the design and creation of synthetic scaffolds for use in tissue engineering. Also, we survey through new and novel merging era of "bioprinting."

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“…The bio-ink is emerged as the use of ink-jet printing, including polymer and hydrogel for scaffolds, growth factors, cells in tissue engineering. In this review, we focus the hydrogel for scaffold (10), capable to provide cellular microenvironment (11,12) and building blocks for 3D bio-printing (13). The hydrogels are the polymeric materials derived from naturally or synthetically, capable of embedding water in their three-dimensional network.…”

Section: Introductionmentioning

confidence: 99%

Bio-ink Materials for 3D Bio-printing

Kim¹,

Hong²,

Hwang³

2016

Journal of International Society for Simulation Surgery

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3D printing is also known as additive manufacturing technique in which has been used in various commercial fields such as engineering, art, education, and medicine. The applications such as fabrication of tissues and organs, implants, drug delivery, creation surgical models using 3D printer in medical field are expanding. Recently, 3D printing has been developing for produce biomimetic 3D structure using biomaterials containing living cells and that is commonly called "3D bio-printing". The 3D bio-printing technologies are usually classified four upon printing methods: Laser-assisted printing, Inkjet, extrusion, and stereolithograpy. In the bio-printing, bio-inks (combined hydrogels and living cells) are as important components as bio-printing technologies. The presence of various types of bioinks, however, in this review, we focused on the bio-inks which enables bioprinting efficacy using hydrogels with living cells.

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Engineering three-dimensional cell mechanical microenvironment with hydrogels

Cited by 157 publications

References 116 publications

3D printing of layered brain-like structures using peptide modified gellan gum substrates

3D printing of layered brain-like structures using peptide modified gellan gum substrates

Application of 3-D Printing for Tissue Regeneration in Oral and Maxillofacial Surgery: What is Upcoming?

Bio-ink Materials for 3D Bio-printing

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