Engineering Nanoassemblies of Polysaccharides

Boddohi, Soheil; Kipper, Matt J.

doi:10.1002/adma.200903790

Cited by 140 publications

(100 citation statements)

References 259 publications

(380 reference statements)

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“…Each disaccharide unit is composed of one hexosamine (D-galactosamine or D-glucosamine) and one uronic acid (D-glucuronic acid or L-iduronic acid) or neutral hexose (D-galactose) (91). Hyaluronic acid, chondroitin sulfate, dermatan sulfate, heparin, heparin sulfate, and keratan sulfate are some of the important compounds in this class (73,92). GAGs are molecules with high negative charge and impart high viscosity to the solution (93).…”

Section: Polysaccharidesmentioning

confidence: 99%

Biodegradable Polymers: Medical Applications

Kunduru

Basu

Domb

2016

Encyclopedia of Polymer Science and Technology

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Biodegradable polymers are the “green materials” of the future. They break down into smaller chemical fragments and are finally eliminated from the body. Biodegradable polymers have been used for more than 50 years with diverse applications such as surgical sutures, wound dressings, tissue regeneration, enzyme immobilization, controlled drug delivery and gene delivery, tissue engineering scaffold, cryopreservation, nanotechnology, medical implants and devices, prosthetics, augmentation, cosmetics, sanitation products, coatings, adhesives, and many more. This article reviews synthetic (esters, amides, ethers, urethanes) and natural (polysaccharides and proteins) biodegradable polymers, highlighting their biomedical applications.

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Section: Polysaccharidesmentioning

confidence: 99%

Biodegradable Polymers: Medical Applications

Kunduru

Basu

Domb

2016

Encyclopedia of Polymer Science and Technology

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“…While oligosaccharides and polysaccharides are known to form fibres by electrospinning [15,31,32,38], the electrospinning of mono-or disaccharide-based solutions into fibres has not been reported yet. However, there are reports of the potential applications that low molecular weight saccharides could have in medicine, biology and microbiology [39] as well as in electrochemistry, and nanotechnology [40]. Hence, the electrospinning of saccharides could lead to the development of new devices for biosensing and drug-delivery [32,38,41,42].…”

Section: Introductionmentioning

confidence: 99%

Sub-micron sized saccharide fibres via electrospinning

Lepe¹,

Tucker²,

Simmons³

et al. 2015

Electrospinning

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Abstract:In this work, the production of continuous submicron diameter saccharide fibres is shown to be possible using the electrospinning process. The mechanism for the formation of electrospun polymer fibres is usually attributed to the physical entanglement of long molecular chains. The ability to electrospin continuous fibre from a low molecular weight saccharides was an unexpected phenomenon. The formation of sub-micron diameter "sugar syrup" fibres was observed in situ using highspeed video. The trajectory of the electrospun saccharide fibre was observed to follow that typical of electrospun polymers. Based on initial food grade glucose syrup tests, various solutions based on combinations of syrup components, i.e. mono-, di-and tri-saccharides, were investigated to map out materials and electrospinning conditions that would lead to the formation of fibre. This work demonstrated that sucrose exhibits the highest propensity for fibre formation during electrospinning amongst the various types of saccharide solutions studied. The possibility of electrospinning low molecular weight saccharides into sub-micron fibres has implications for the electrospinability of supramolecular polymers and other biomaterials.

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“…NPs requires that the constituent polyelectrolyte solutions are mixed in non-stoichiometric ratios 529 (Boddohi and Kipper, 2010). The amount of CHON incorporated in NPs is presented in Figure 1S The stability of polyelectrolyte complex NPs depends on the repulsion between similarly charged 532 particles.…”

Section: Umerskamentioning

confidence: 99%

“…On the other hand, it has been shown that, as a result of charge 526 neutralisation, aggregation of polyelectrolyte complex NPs occurs and a phase separation takes 527 place (Boddohi et al, 2009; Umerska et al, 2012). The formation of stable polyelectrolyte complex 528NPs requires that the constituent polyelectrolyte solutions are mixed in non-stoichiometric ratios 529 (Boddohi and Kipper, 2010). The amount of CHON incorporated in NPs is presented in Figure 1S The stability of polyelectrolyte complex NPs depends on the repulsion between similarly charged 532 particles.…”

mentioning

confidence: 99%

Chondroitin-based nanoplexes as peptide delivery systems – Investigations into the self-assembly process, solid-state and extended release characteristics

Umerska

Paluch

Santos-Martínez

et al. 2015

European Journal of Pharmaceutics and Biopharmaceutics

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A new type of self-assembled polyelectrolyte complex nanocarrier composed of chondroitin 18 (CHON) and protamine (PROT) was designed and the ability of the carriers to bind salmon 19 calcitonin (sCT) was examined. The response of sCT-loaded CHON/PROT NPs to a change in 20 the properties of the liquid medium, e.g. its pH, composition or ionic strength was studied and in 21 vitro peptide release assessed. The biocompatibility of the NPs was evaluated in Caco-2 cells. 22 CHON/PROT NPs were successfully obtained with properties that were dependent on the 23 concentration of the polyelectrolytes and their mixing ratio. X-ray diffraction determined the 24 amorphous nature of the negatively charged NPs, while those with the positive surface potential 25were semi-crystalline. sCT was efficiently associated with the nanocarriers (98-100%) and a 26 notably high drug loading (13-38%) was achieved. The particles had negative zeta potential 27 values and were homogenously dispersed with sizes between 60 and 250 nm. CHON/PROT NPs 28 released less than 10% of the total loaded peptide in the first hour of the in vitro release studies. MEM -Eagle's Minimal Essential Medium 67MMR -mass mixing ratio 68 MPS -mean particle size 69MTS -3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium 70 MWCO -molecular weight cut-off 71 NP -nanoparticle 72 PBS -phosphate-buffered saline 73 PDI -polydispersity index 74PROT -protamine 75 PXRD -powder X-ray diffraction 76sCT -salmon calcitonin 77 Tg -glass transition 78 TR -transmittance 79ZP -zeta potential 80 81 Introduction 82Considerable efforts have been dedicated towards incorporation of bioactive ingredients into 83 nanoparticles (NPs) composed of biodegradable polymers (Hamidi et al., 2008). There are a 84 considerable number of polymers and techniques that are used to produce NPs, which allows a 85 broad differentiation of their internal and external structures as well as composition and biological 86properties. The choice of the nanoparticle manufacturing method is influenced by the solubility of 87 the active compound to be associated/complexed with the NPs as well as the solubility, chemical 88 structure, characteristic chemical groups, molecular weight and crystallinity/amorphicity of the 89 polymer (des Rieux et al., 2006). The most commonly used polymers are polyesters (e.g. 90 5 poly(lactic acid) and poly(lactic-co-glycolic acid)), either alone or in combination with other 91 polymers (des Rieux et al., 2006). However, the limitation of biodegradable water-insoluble 92 polymers is that they are mostly hydrophobic, whereas nucleic acids, many peptides and proteins, 93 which are recognised to have a great potential in therapeutics, are hydrophilic. This leads to 94 difficulties for the drug to be efficiently encapsulated (Sundar et al., 2010). Hence, the preparation 95 of NPs with the employment of more hydrophilic and naturally occurring polymers has been 96 explored. Among polymeric NPs, those composed of polyelectrolytes (polyelectrolyte complex ...

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Engineering Nanoassemblies of Polysaccharides

Cited by 140 publications

References 259 publications

Biodegradable Polymers: Medical Applications

Biodegradable Polymers: Medical Applications

Sub-micron sized saccharide fibres via electrospinning

Chondroitin-based nanoplexes as peptide delivery systems – Investigations into the self-assembly process, solid-state and extended release characteristics

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