Biodegradable Polymers: Medical Applications

Kunduru, Konda Reddy; Basu, Arijit; Domb, Abraham J.

doi:10.1002/0471440264.pst027.pub2

Cited by 27 publications

(30 citation statements)

References 161 publications

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“…Polymers are one of the major chemical compounds which find an important place in the field of engineering, medicine and pharmaceutical field these days and the major focus has been on the biodegradable ones, alginates in particular [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Formulation and Characterization of Alginate-Based Membranes for the Potential Transdermal Delivery of Methotrexate

et al. 2021

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The aim of this study is to obtain and characterize of alginate-based membranes, as well as to choose the most suitable membrane type for the transdermal release of methotrexate. The paper presents the synthesis of four types of membranes based on alginate to which are added other copolymers (Carbopol, Tween, and Polyvinylpyrrolidone) as well as other components with different roles. Membranes and binary mixtures made between the components used in membrane synthesis and methotrexate are analyzed by thermogravimetric techniques, FTIR and UV spectroscopic techniques as well as SEM. The analyses aim to establish the type of membrane most indicated in the use of the controlled release of methotrexate, namely those membranes in which there are no interactions that could inactivate the active substance. Following these studies, it was concluded that membranes obtained from alginate/alginate and Tw can be used for methotrexate release. The membrane obtained from alginate and carbopol was excluded from the beginning because it is not homogeneous. Regarding the AGP-MTX membrane, it presents interactions with the active substance, carboxylate group interactions argued by TGA and FTIR studies, and interactions that occur in aqueous medium.

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Section: Introductionmentioning

confidence: 99%

Formulation and Characterization of Alginate-Based Membranes for the Potential Transdermal Delivery of Methotrexate

et al. 2021

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“…53 Synthetic polymers, on the other hand, are usually nonenzymatically degraded. 52 The most widely used biodegradable synthetic polymers typically contain ester bonds that facilitate hydrolytic degradation in acidic or alkaline conditions. 54 Amide, sulfonamide, anhydride, carbonate, ether, imide, imine, phosphonate, thioester, urea, and urethane bonds also serve as unstable sites susceptible to hydrolytic degradation ( Figure 1 ).…”

Section: Structural and Functional Materials For Biodegradable Sensorsmentioning

confidence: 99%

Biodegradable Materials for Sustainable Health Monitoring Devices

Hosseini

Dervin

Ganguly

et al. 2020

ACS Appl. Bio Mater.

169

149

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The recent advent of biodegradable materials has offered huge opportunity to transform healthcare technologies by enabling sensors that degrade naturally after use. The implantable electronic systems made from such materials eliminate the need for extraction or reoperation, minimize chronic inflammatory responses, and hence offer attractive propositions for future biomedical technology. The eco-friendly sensor systems developed from degradable materials could also help mitigate some of the major environmental issues by reducing the volume of electronic or medical waste produced and, in turn, the carbon footprint. With this background, herein we present a comprehensive overview of the structural and functional biodegradable materials that have been used for various biodegradable or bioresorbable electronic devices. The discussion focuses on the dissolution rates and degradation mechanisms of materials such as natural and synthetic polymers, organic or inorganic semiconductors, and hydrolyzable metals. The recent trend and examples of biodegradable or bioresorbable materials-based sensors for body monitoring, diagnostic, and medical therapeutic applications are also presented. Lastly, key technological challenges are discussed for clinical application of biodegradable sensors, particularly for implantable devices with wireless data and power transfer. Promising perspectives for the advancement of future generation of biodegradable sensor systems are also presented.

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“…Pyrolysis can occur sequentially with the formation of α-acyloxy acid, an intermediate product subsequently converted into acrylic acid by a concerted mechanism (Fig. 47, reactions 1,3,[4][5][6]. Experimental development of this hypothesis would help create a new method to synthesize acrylic acid from lactide, the former being a valuable vinyl monomer [275].…”

Section: Fig 47 Possible Routes Of Lactide Pyrolysismentioning

confidence: 99%

“…Biodegradable polymers have applications in biomedicine [1,2] as well as in packaging [3], modern additive technologies [4], and even in agriculture [5]. Biodegradable polymers can either be natural in origin (e.g.…”

Section: Introductionmentioning

confidence: 99%

Syntheses and chemical transformations of glycolide and lactide as monomers for biodegradable polymers

Ботвин

Karaseva

Salikova

et al. 2021

Polymer Degradation and Stability

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Glycolide and lactide function as the commonly used diester monomers for the preparation of high-molecular weight, degradation-prone (co-)polyesters. Both glycolide and lactide-based polymers are widely used in medicine, pharmaceuticals, the food industry, and additive technologies. This review on the diesters, spanning research from 1833-1854 to the present, encompassing their structural peculiarities, physico-chemical properties, and the range of different methods for obtaining themincluding reaction mechanismsfrom lactic and glycolic acids, their esters, and halogen derivatives. The review also discusses the chemical transformations of lactide and glycolide (apart from ring-opening polymerization) into valuable organic and high-molecular compounds, such as acrylic acid, nitrogen-containing heterocycles, and functional polymers with novel properties.

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Biodegradable Polymers: Medical Applications

Cited by 27 publications

References 161 publications

Formulation and Characterization of Alginate-Based Membranes for the Potential Transdermal Delivery of Methotrexate

Formulation and Characterization of Alginate-Based Membranes for the Potential Transdermal Delivery of Methotrexate

Biodegradable Materials for Sustainable Health Monitoring Devices

Syntheses and chemical transformations of glycolide and lactide as monomers for biodegradable polymers

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