2015
DOI: 10.1021/nn505330w
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Engineering Cortical Neuron Polarity with Nanomagnets on a Chip

Abstract: Intra- and extracellular signaling play critical roles in cell polarity, ultimately leading to the development of functional cell-cell connections, tissues, and organs. In the brain, pathologically oriented neurons are often the cause for disordered circuits, severely impacting motor function, perception, and memory. Aside from control through gene expression and signaling pathways, it is known that nervous system development can be manipulated by mechanical stimuli (e.g., outgrowth of axons through externally… Show more

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Cited by 56 publications
(88 citation statements)
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“…Although high amplitude Ca 2+ influxes were observed in the latter case, 154 and intracellular distribution of proteins 54,155 and suggest the use of wireless magnetic forces to remotely modulate neural network activity.…”
Section: Introductionmentioning
confidence: 89%
See 3 more Smart Citations
“…Although high amplitude Ca 2+ influxes were observed in the latter case, 154 and intracellular distribution of proteins 54,155 and suggest the use of wireless magnetic forces to remotely modulate neural network activity.…”
Section: Introductionmentioning
confidence: 89%
“…53 It has been shown that internalized MNPs can influence the protein tau distribution which affects the polarization of neurites for axon formation. 54 Calcium is an important second messenger that is implicated in various signaling pathways that regulate gene expression. 55 In order to act as a specific second messenger, cytoplasmic calcium 9 concentration is maintained at a much lower concentration (100-300 nM) compared to extracellular spaces (1-3 mM) and endoplasmic reticulum (10-100 µM).…”
Section: Nano-technology Toolsmentioning
confidence: 99%
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“…Thus, through engineering Tau concentrations in neurons we may prevent neurons from degenerating their networks, especially, when no other growth cues are available. In this context, we have shown previously that a nanomagnetic force stimulus 5 – 70 pN, applied over 24 hours, locally modulated Tau distribution in cortical neurons 34 While the translocation of Tau was related to the nanomagnetic force strength, how vesicle transport gets impacted under the application of nanomagnetic forces remains an open question.…”
Section: Introductionmentioning
confidence: 98%