Engineered Polymer Brushes by Carbon Templating

Tailored Poly(2‐oxazoline) Polymer Brushes to Control Protein Adsorption and Cell Adhesion

“…As SIPGP does not result in polymer grafting directly on silica surfaces because of the high bond dissociation energy of the surface silanol groups,73 a SAM of α , ω ‐aminopropyltrimethoxysilane (APTMS) was used as the primary layer. The terminal amino function is most suitable for this purpose since it catalyses the silanization reaction and it is the most effective surface function for the SIPGP due to the low bond dissociation energy of the N–H bond 68.…”

“…However, since polyethers are prone to oxidative degradation, the non‐degradable peptide‐like POx polymer might be the better choice if a long‐term use within the human body is desired. Since the SIPGP grafting approach is suitable for almost all kinds of substrates including materials of exceptional mechanical strength such as diamond,65, 87 silicon carbide,88 graphene,89 and all carbon templated inorganic materials,73 the presented approach have high potential for the development of long‐term anti‐fouling coatings of implants and functional biosensors.…”

Poly(2‐oxazoline)s as Polymer Therapeutics

“…[138] These results highlight the potential of POx as ideal alternatives to PEG for protein conjugation to modulate the delivery, protein activity and stability. Hutter et al [139] prepared patterned bottle-brush brushes (BBBs) of poly(2-isopropenyl-2-oxazoline-g-PEtOx) on diamond by carbon templating [140] and coupled green fluorescence protein (GFP) onto the pendant PEtOx chain ends. Besides the surprisingly high conjugation efficiency onto the BBBs, it was found that for polymer-brush-GFP conjugate the protein keeps its native state and the protein stability significantly improved as compared to the free GFP.…”

Electrons as “Invisible Ink”: Fabrication of Nanostructures by Local Electron Beam Induced Activation of SiOx

“…This effect can also be exploited directly to generate carbonaceous deposits, for example, as templates for the growth of polymer brushes. [10] To avoid such contaminations, we apply a "surface-science" approach, namely EBID under ultrahigh vacuum (UHV) conditions on well-defined samples. [11][12][13] By following this approach and using [Fe(CO) 5 ] we were able to produce very clean iron nanostructures with a metal content of greater than 95 % and partially with dimensions below 10 nm.…”