Poly(2‐oxazoline)s as Polymer Therapeutics

Abstract

Poly(2-oxazoline)s (POx) are currently discussed as an upcoming platform for biomaterials design and especially for polymer therapeutics. POx meets several requirements needed for the development of next-generation polymer therapeutics such as biocompatibility, high modulation of solubility, variation of size, architecture as well as chemical functionality. Although in the early 1990s first and promising POx-based systems were presented but the field lay dormant for almost two decades. Only very recently, POx based polymer therapeutics came back into the focus of very intensive research. In this review, we give an overview on the chemistry and physicochemical properties of POx and summarize the research of POx-protein conjugates, POx-drug conjugates, POx-based polyplexes and POx micelles for drug delivery.

In-vitro cytotoxic activities of poly(2-ethyl-2-oxazoline)-based amphiphilic block copolymers prepared by CuAAC click chemistry

“…Although PEtOx-N 3 and PCL-alkyne led to decrease cell viability at early time points for 22RV1 and LnCAP cells at later time points this effect was compensated and the viable cell number for 22RV1 and LnCAP cells was comparable to the non-treated control pointing at a possible cytostatic effect of these polymers. According to the study conducted by Luxenhofer and coworkers, the cytotoxicity of PEtOxs on healthy and cancer cells may have vary due to their chemical and physical properties [62].…”

Thermal Properties of Methyl Ester-Containing Poly(2-oxazoline)s

“…A polymer class that fulfills these requirements is the class of poly(2-alkyl/aryl-2-oxazoline)s (PAOx) as they are biocompatible, thermoresponsive, and have tunable properties [15,21,22].…”

“…Poly(2-methyl-2-oxazoline) (PMeOx) and poly(2-ethyl-2-oxazoline) (PEtOx) are interesting for biomedical applications because they show stealth behaviour similar to poly(ethylene glycol) (PEG) [15,[21][22][23][24][25].…”

Design Strategies for Functionalized Poly(2-oxazoline)s and Derived Materials

“…The most recent developments published in the last ten years have been focused on during the compilation of this review; crosslinked poly(2-oxazoline)s, which were reviewed in a recent publication, have been omitted from this compilation [10]. While this review focuses on the synthesis of poly(2-oxazoline)s and copoly(2-oxazoline)s as well as the derived materials, the properties of the polymers and materials themselves will be discussed only for dedicated examples, and the reader interested in more and/or more general details is referred to recent reviews in that area [11][12][13][14][15][16][17][18][19][20].…”