Engineered nanogels simultaneously implement HDAC inhibition and chemotherapy to boost antitumor immunity via pyroptosis

Chen, De-Run; Gao, Yuan; Xiao, Yao; Wan, Shu-Yen; Wu, Zhi‐Zhong; Ma, Xianbin; Xu, Zhigang; Sun, Zhi‐Jun

doi:10.1016/j.apmt.2022.101363

Cited by 10 publications

(8 citation statements)

References 62 publications

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“…130 Histone deacetylase inhibitors (HDACIs) are used as epigenetic agents; thus, we chose LAQ824 as a model molecule, and further selected the chemotherapeutic drug DOX by using the cross-linker described above to prepare nanogels (LD NPs). 132 After reaching the tumour, site-specific release of LAQ824 activated caspase 3-mediated tumour pyroptosis, which further enhanced the immune effect by cooperating with DOX (Fig. 8c).…”

Section: Nanogels For Immunomodulatory Therapeuticsmentioning

confidence: 95%

Bioengineered nanogels for cancer immunotherapy

Liu

et al. 2022

Chem. Soc. Rev.

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100

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Section: Nanogels For Immunomodulatory Therapeuticsmentioning

confidence: 95%

Bioengineered nanogels for cancer immunotherapy

Liu

et al. 2022

Chem. Soc. Rev.

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100

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“…[36] Meanwhile, Chen et al have claimed that histone deacetylase inhibitors (HDACIs) and chemotherapeutic drugs can work together to have good infiltration, tumor permeability, and long-term retention characteristics (Figure 3h,i), which could trigger tumor cell pyroptosis and antitumor therapy. [34] Interestingly, pH-responsive prodrug nanomicelles of PDONPs loads Src inhibitors, and chemotherapy also could release drugs precisely in acidic TME (Figure 3c,d). [37] "PhotoPyro" is an innovative approach that utilizes photoncontrolled pyroptosis activation to enhance systemic immunity through photoirradiation.…”

Section: The Nanogel Of Inducing Pyroptosismentioning

confidence: 99%

“…[68] Mild PTT also offers the possibility of avoiding the damage of high temperatures to paracancerous tissues mitochondrial dysfunction and inducing pyroptosis. [66] Several studies have demonstrated that epigenetics may [33][34][35][36] Copyright 2023, The Royal Society of Chemistry. Copyright 2021, Wiley-VCH GmbH.…”

Section: The Polymer Prodrug Of Inducing Pyroptosismentioning

confidence: 99%

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Biomaterials Elicit Pyroptosis Enhancing Cancer Immunotherapy

Zhang,

Wang,

Han

et al. 2023

Adv Funct Materials

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Cancer immunotherapy has the potential to revolutionize the treatment of malignant tumors, but its effectiveness is limited by the low immune response rate and immune‐related adverse events. Pyroptosis, as an inflammatory programmed cell death type, triggers strong acute inflammatory response and antitumor immunity, converting “cold” tumors to “hot”. Particularly, biomaterials loading pyroptosis inducers targeting the tumor microenvironment to engineer pyroptosis, have achieved great progress in recent years. Herein, the design strategy, mechanism pathway, and role of biomaterials to induce pyroptosis in cancer immunotherapy are comprehensively reviewed. The present review focuses on the application of biomaterials‐induced pyroptosis in cancer immunotherapy, including nanogel, polymer prodrug, nanovesicle, and mesoporous material. Additionally, the synthesis of a series of stimuli‐responsive nanoplatforms, including glutathione‐responsive, pH‐responsive, reactive oxygen species‐responsive, and enzyme‐mimicking catalytic performance, is described. Meanwhile, it augments multiple immune response processes of cell uptake, antigen presentation, T‐cell activation, and expansion. Finally, the perspectives of pyroptosis‐mediated inflammation to break through the tumor vascular basement membrane barrier achieving efficient volcanic penetration of biomaterials are discussed. Artificial intelligence, multi‐omics analysis, and anthropogenic animal models of organoids are presented, aiming to provide guidance and assistance for constructing effective and controllable pyroptosis‐engineered biomaterials and improving tumor immunotherapy.

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“…11 Meanwhile, the reports demonstrated that many nanodrugs loaded with targeted inhibitors can trigger pyroptosis. 12 Interestingly, BRAFi promotes the cleavage of GSDME, therefore regulating the TME by inducing pyroptosis and propagating T cell activity. 13 Additionally, caspase-3 activity was increased significantly by COX2i.…”

mentioning

confidence: 99%