Bioengineered nanogels for cancer immunotherapy

Ma, Xianbin; Li, Shu-Jin; Liu, Yuantong; Tian, Ziqiang; Xue, Peng; Kang, Yuejun; Sun, Zhi‐Jun; Xu, Zhigang

doi:10.1039/d2cs00247g

Cited by 100 publications

(54 citation statements)

References 325 publications

(422 reference statements)

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“…Although immune checkpoint blockers have been shown to be effective against many types of advanced cancer, the overall patient response rate is still less than 30% ( Carlino et al, 2021 ; Lommerts et al, 2021 ). This is mainly due to the immunomodulatory interactions between tumor cells and the ITM ( Ma et al, 2022 ), which jointly mediate the immune tolerance of a tumor and, correspondingly, affect the positive response to immunotherapy ( Kyu Shim et al, 2022 ). Thus, there is an urgent need to improve current cancer immunotherapies.…”

Section: Mechanisms Of Cancer Immunotherapymentioning

confidence: 99%

Biomimetic nanoparticles for tumor immunotherapy

Chen

et al. 2022

Front. Bioeng. Biotechnol.

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Currently, tumor treatment research still focuses on the cancer cells themselves, but the fact that the immune system plays an important role in inhibiting tumor development cannot be ignored. The activation of the immune system depends on the difference between self and non-self. Unfortunately, cancer is characterized by genetic changes in the host cells that lead to uncontrolled cell proliferation and evade immune surveillance. Cancer immunotherapy aims to coordinate a patient’s immune system to target, fight, and destroy cancer cells without destroying the normal cells. Nevertheless, antitumor immunity driven by the autoimmune system alone may be inadequate for treatment. The development of drug delivery systems (DDS) based on nanoparticles can not only promote immunotherapy but also improve the immunosuppressive tumor microenvironment (ITM), which provides promising strategies for cancer treatment. However, conventional nano drug delivery systems (NDDS) are subject to several limitations in clinical transformation, such as immunogenicity and the potential toxicity risks of the carrier materials, premature drug leakage at off-target sites during circulation and drug load content. In order to address these limitations, this paper reviews the trends and progress of biomimetic NDDS and discusses the applications of each biomimetic system in tumor immunotherapy. Furthermore, we review the various combination immunotherapies based on biomimetic NDDS and key considerations for clinical transformation.

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Section: Mechanisms Of Cancer Immunotherapymentioning

confidence: 99%

Biomimetic nanoparticles for tumor immunotherapy

Chen

et al. 2022

Front. Bioeng. Biotechnol.

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“…29 The rapid development of nanotechnology can optimize the effectiveness of CGA and thus promote the application of CGA in biomedicine. [30][31][32][33][34] Studies have reported that CGA-loaded nanoparticles could enhance the antioxidant activity of CGA. 35,36 Poly(D,L-lactide-co-glycolide) (PLGA) nanomicelles have been widely used in biomedical applications because of their biocompatibility and are considered as the preferred drug carriers.…”

Section: Introductionmentioning

confidence: 99%

Sustained release of chlorogenic acid-loaded nanomicelles alleviates bone loss in mouse periodontitis

et al. 2022

Biomater. Sci.

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“…[17,18] Unlike free contrast agents, nanoparticle (NP)-based imaging strategies offer advantages such as deep penetration of the tumor, selective lymph node positioning and imaging, prolonged blood circulation time, and accurate prediction ability owing to autonomic adaptation. [19,20] At present, different types of nanoparticles have been explored for the manufacture of biosensors, including liposomes, polymer nanoparticles, persistent luminescence nanoparticles, membranebased nanoparticles, microneedles and inorganic nanoparticles, among others. [15,[21][22][23] The use of nanotechnology provides broad prospects for detecting immunotherapy-related markers and monitoring the complex immune microenvironment.…”

Section: Introductionmentioning

confidence: 99%

Emerging Biomaterials Imaging Antitumor Immune Response

Zhang

Wang

et al. 2022

Advanced Materials

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Immunotherapy is one of the most promising clinical modalities for the treatment of malignant tumors and has shown excellent therapeutic outcomes in clinical settings. However, it continues to face several challenges, including long treatment cycles, high costs, immune‐related adverse events, and low response rates. Thus, it is critical to predict the response rate to immunotherapy by using imaging technology in the preoperative and intraoperative. Here, the latest advances in nanosystem‐based biomaterials used for predicting responses to immunotherapy via the imaging of immune cells and signaling molecules in the immune microenvironment are comprehensively summarized. Several imaging methods, such as fluorescence imaging, magnetic resonance imaging, positron emission tomography imaging, ultrasound imaging, and photoacoustic imaging, used in immune predictive imaging, are discussed to show the potential of nanosystems for distinguishing immunotherapy responders from nonresponders. Nanosystem‐based biomaterials aided by various imaging technologies are expected to enable the effective prediction and diagnosis in cases of tumors, inflammation, and other public diseases.

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Bioengineered nanogels for cancer immunotherapy

Abstract: Recent years have witnessed increasingly rapid advances in nanocarrier-based biomedicine aimed at improving treatment paradigms for cancer.

Cited by 100 publications

References 325 publications

Biomimetic nanoparticles for tumor immunotherapy

Biomimetic nanoparticles for tumor immunotherapy

Sustained release of chlorogenic acid-loaded nanomicelles alleviates bone loss in mouse periodontitis

Emerging Biomaterials Imaging Antitumor Immune Response

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