Sustained release of chlorogenic acid-loaded nanomicelles alleviates bone loss in mouse periodontitis

Li, Han; Xu, Jiming; Hu, Jian; Hu, Qingyun; Fang, Xiaolin; Sun, Zhi-Jun; Xu, Zhigang; Zhang, Lu

doi:10.1039/d2bm01099b

Cited by 18 publications

(15 citation statements)

References 54 publications

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“…Huang, Xin found that in ammation in LPS-induced human gingival broblasts via CysLT1R/Nrf2/NLRP3 signaling is attenuated by chlorogenic acid [40]. Not singly, but in pairs, Li, Han, and his colleagues reported that the sustained release of chlorogenic acid inhibits alveolar bone resorption and prevents periodontitis progression in a mouse model [41]. Notably, a study investigated the effect of caffeine and chlorogenic acid on periodontitis.…”

Section: Discussionmentioning

confidence: 99%

WITHDRAWN: Coffee and Caffeine Consumption and Risk of Periodontitis: NHANES 2009 to 2014

Guo

Liao

Zhou

et al. 2023

Preprint

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Objectives In this study, assessing whether coffee consumption and caffeine intake were associated with periodontitis infection separately was set as the objective. Materials and Methods Divided into binary and continuous categories, coffee consumption was set as the exposure variable along with caffeine intake and periodontitis infection as the outcome variables. Other covariables were regarded as potential confounders. The cross-sectional study was conducted based on the National Health and Nutrition Examination Survey, with multivariate regression models, subgroup analyses, smooth fitting curves, and threshold effect examinations conducted to pursue a definite correlation between exposures and the outcome. Results Negative associations were discovered between binary coffee consumption and caffeine intake and periodontitis infection, with all confounders adjusted. In subgroup analyses stratified by sex, diabetes mellitus status, and hypertension status, interaction and threshold effects were observed, which were revealed intuitively by smooth-fitting curves. Conclusions Significant negative associations between binary consumption and caffeine intake and periodontitis infection separately were indicated, with no evidence suggesting a credible correlation between continuous coffee consumption and periodontitis infection risk. The benefits of the behavior of consuming coffee and consuming caffeine were more obvious among males and individuals who do not suffer from diabetes or hypertension.

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Section: Discussionmentioning

confidence: 99%

WITHDRAWN: Coffee and Caffeine Consumption and Risk of Periodontitis: NHANES 2009 to 2014

Guo

Liao

Zhou

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…Huang et al found that inflammation in LPS‐induced Human gingival fibroblasts via CysLT1R/Nrf2/NLRP3 signaling is attenuated by chlorogenic acid [37]. Not singly, but in pairs, Han Li and his colleagues reported that the Sustained release of chlorogenic acid inhibits alveolar bone resorption and prevents periodontitis progression in a mouse model [38]. What is worth mentioning that a study investigated the effect of caffeine and chlorogenic acid on periodontitis.…”

Section: Discussionmentioning

confidence: 99%

Coffee and caffeine consumption and risk of periodontitis: National Health and Nutrition Examination Survey 2009–2014

Liao,

Zhou,

et al. 2024

Medicine Advances

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BackgroundThis study aimed to evaluate whether coffee consumption and caffeine intake are independently associated with periodontitis infection.MethodsCoffee consumption was categorized into binary and continuous variables, serving as the exposure factor alongside caffeine intake, with periodontitis infection as the outcome variable. Other covariables were regarded as potential confounders. The cross‐sectional study was conducted based on the national health and nutrition examination survey, with multivariate regression models, subgroup analyses, smooth fitting curves, and threshold effect examinations conducted to pursue a definite correlation between exposures and the outcome.ResultsNegative associations were discovered between binary coffee consumption (OR = 0.81, 95% CI = (0.71, 0.92), p‐value = 0.001) and caffeine intake (Q3: OR = 0.77, 95% CI = (0.66, 0.91), p‐value = 0.002; Q4: OR = 0.76, 95% CI = (0.64, 0.90), p‐value = 0.001) with periodontitis infection, respectively, with all confounders adjusted. In subgroup analyses stratified by gender, diabetes mellitus status, and hypertension status, interaction, and threshold effects were observed, which were intuitively revealed by smooth‐fitting curves.ConclusionsSignificant negative associations between binary consumption and caffeine intake and periodontitis infection separately were indicated, with no evidence suggesting a credible correlation between continuous coffee consumption and infection risk of periodontitis. The benefits of the behavior of consuming coffee and caffeine were more obvious among males and individuals who did not suffer from diabetes or hypertension.

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“…36 Drug release properties of CGA CGA exhibits several pharmacological properties (e.g., strong water solubility, short half-life and low bioavailability), which only reached (1.3 ± 0.6) h under the effect of the relatively short elimination half-life (t 1/2 ). [41][42][43] Therefore, it is crucial to select an appropriate drug carrier, such as hydrogel microspheres, that can create a porous network to exhibit the high resolution control of spatial tissue and effectively release the drug in a controlled manner. [44][45][46] Then, the CGA-loaded CGM sample was evaluated as a drug delivery vehicle.…”

Section: Swelling and Degradation Of Microspheresmentioning

confidence: 99%

Chlorogenic acid releasing microspheres enhanced electrospun conduits to promote peripheral nerve regeneration

Fang,

Jin,

et al. 2023

Biomater. Sci.

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Sustained release of chlorogenic acid-loaded nanomicelles alleviates bone loss in mouse periodontitis

Abstract: Periodontitis is a prevalent chronic inflammatory disease that destroys the periodontal supporting tissues, impinges on oral health, and is correlative with an increased risk of systemic disease. Currently, the...

Cited by 18 publications

References 54 publications

WITHDRAWN: Coffee and Caffeine Consumption and Risk of Periodontitis: NHANES 2009 to 2014

WITHDRAWN: Coffee and Caffeine Consumption and Risk of Periodontitis: NHANES 2009 to 2014

Coffee and caffeine consumption and risk of periodontitis: National Health and Nutrition Examination Survey 2009–2014

Chlorogenic acid releasing microspheres enhanced electrospun conduits to promote peripheral nerve regeneration

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