Engineered bioactive nanoparticles incorporated biofunctionalized ECM/silk proteins based cardiac patches combined with MSCs for the repair of myocardial infarction: In vitro and in vivo evaluations

Dong, Yan; Hong, Mingsheng; Dai, Ruozhu; Wu, Haiyun; Zhu, Ping

doi:10.1016/j.scitotenv.2019.135976

Cited by 48 publications

(45 citation statements)

References 46 publications

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“…Nanomodification with inorganic particles (gold particles) of ECM/silk fibroin (SF) and MSC offered a new patch suitable for cardiac tissue engineering. The distribution of homogeneous AuNPs demonstrated to provide favourable conductivity, in vitro enhanced cell compatibility, retention of CM survival and in vivo decreasing of infarct size from 89% to 65% in the control group [44].…”

Section: Inorganic Nanoparticlesmentioning

confidence: 94%

Nanoengineering in Cardiac Regeneration: Looking Back and Going Forward

et al. 2020

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To deliver on the promise of cardiac regeneration, an integration process between an emerging field, nanomedicine, and a more consolidated one, tissue engineering, has begun. Our work aims at summarizing some of the most relevant prevailing cases of nanotechnological approaches applied to tissue engineering with a specific interest in cardiac regenerative medicine, as well as delineating some of the most compelling forthcoming orientations. Specifically, this review starts with a brief statement on the relevant clinical need, and then debates how nanotechnology can be combined with tissue engineering in the scope of mimicking a complex tissue like the myocardium and its natural extracellular matrix (ECM). The interaction of relevant stem, precursor, and differentiated cardiac cells with nanoengineered scaffolds is thoroughly presented. Another correspondingly relevant area of experimental study enclosing both nanotechnology and cardiac regeneration, e.g., nanoparticle applications in cardiac tissue engineering, is also discussed.

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Section: Inorganic Nanoparticlesmentioning

confidence: 94%

Nanoengineering in Cardiac Regeneration: Looking Back and Going Forward

et al. 2020

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“…Enhanced survival and retention of CMs, decreased LV wall thickness and infarct size [ 165] SF/CNTs Nanofibrous scaffolds CMs None Improved cell spreading, guided cell organization, and induced the formation of aligned cardiac tissues [ 164] SF/PCL/CNTs/ methacrylated gelatin 3D hybrid scaffolds CMs and ECs None Promoted endothelialization and CMs maturation, and controlled CMs orientation [ 170] SF/PPy Nanopatterned film hPSC-CMs None Promoted structural organization, contractile apparatus development, and maturation of CMs [ 171] synchronously, and enhanced the formation of sarcomere and gap connections by increasing the expression of cardiac-specific proteins, thereby promoting cell-cell communication and function of CMs in vitro. Dong et al prepared the Au-ECM/SF patches by coating the functionalized AuNPs on the ECM (decellularized rats heart tissue)/SF scaffolds.…”

Section: Methodsmentioning

confidence: 99%

Silk‐Based Biomaterials for Cardiac Tissue Engineering

Song

Wang

Yue

et al. 2020

Adv Healthcare Materials

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Cardiovascular diseases are one of the leading causes of death globally. Among various cardiovascular diseases, myocardial infarction is an important one. Compared with conventional treatments, cardiac tissue engineering provides an alternative to repair and regenerate the injured tissue. Among various types of materials used for tissue engineering applications, silk biomaterials have been increasingly utilized due to their biocompatibility, biological functions, and many favorable physical/chemical properties. Silk biomaterials are often used alone or in combination with other materials in the forms of patches or hydrogels, and serve as promising delivery systems for bioactive compounds in tissue engineering repair scenarios. This review focuses primarily on the promising characteristics of silk biomaterials and their recent advances in cardiac tissue engineering.

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“…Only by making the best of the various materials, can the complex objectives of TE be realized. Not only in BTE, modified and recombined GNPs have ample scope for skin [25], nerve [26] and myocardial tissues [27].…”

Section: The Modification and Recombination Of Gnpsmentioning

confidence: 99%

“…These will be covered in detail in section 3 below. [74]. Regarding the mechanism of GNPs inducing osteogenic differentiation, Yi et al [75] believed that GNPs could interact with proteins in the cytoplasm and the extracellular matrix through mechanical stress, causing activation of the p38 MAPK signaling pathway, which in turn causes up-regulation of osteogenic genes and down-regulation of adipogenic genes.…”

Section: Recombinationmentioning

confidence: 99%

Advances in the application of gold nanoparticles in bone tissue engineering

Xia

et al. 2020

J Biol Eng

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The materials used in bone tissue engineering (BTE) have been advancing with each passing day. With the continuous development of nanomedicine, gold nanoparticles (GNPs), which are easy to be synthesized and functionalized, have attracted increasing attention. Recent years have witnessed this amazing material, i.e., GNPs characterized with large surface area to volume ratio, biocompatibility, medical imaging property, hypotoxicity, translocation into the cells, high reactivity, and other properties, perform distinct functions in BTE. However, the low stability of GNPs in the biotic environment makes them in the requirements of modification or recombination before being used. After being combined with the advantages of other materials, the structures of GNPs have exhibited great potential in stem cells, scaffolds, delivery systems, medical imaging, and other aspects. This review will focus on the advances in the application of GNPs after modification or recombination with other materials to BTE.

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Engineered bioactive nanoparticles incorporated biofunctionalized ECM/silk proteins based cardiac patches combined with MSCs for the repair of myocardial infarction: In vitro and in vivo evaluations

Cited by 48 publications

References 46 publications

Nanoengineering in Cardiac Regeneration: Looking Back and Going Forward

Nanoengineering in Cardiac Regeneration: Looking Back and Going Forward

Silk‐Based Biomaterials for Cardiac Tissue Engineering

Advances in the application of gold nanoparticles in bone tissue engineering

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