Silk‐Based Biomaterials for Cardiac Tissue Engineering

Abstract

Cardiovascular diseases are one of the leading causes of death globally. Among various cardiovascular diseases, myocardial infarction is an important one. Compared with conventional treatments, cardiac tissue engineering provides an alternative to repair and regenerate the injured tissue. Among various types of materials used for tissue engineering applications, silk biomaterials have been increasingly utilized due to their biocompatibility, biological functions, and many favorable physical/chemical properties. Silk biomaterials are often used alone or in combination with other materials in the forms of patches or hydrogels, and serve as promising delivery systems for bioactive compounds in tissue engineering repair scenarios. This review focuses primarily on the promising characteristics of silk biomaterials and their recent advances in cardiac tissue engineering.

Designing of spider silk proteins for human induced pluripotent stem cell-based cardiac tissue engineering

“…In order to identify 3D printable new materials, suitable for tissue engineering, the ones made of silk proteins are promising candidates [ [26] , [27] , [28] , [29] ]. We have previously demonstrated that materials made of natural silkworm silk and recombinant silk proteins are suitable for cardiac tissue engineering [ [30] , [31] , [32] ].…”

Microneedle arrays integrated with living organisms for smart biomedical applications

“…What is more, new functionalized materials have drawn increasing attention in this field: (1) Besides biocompatibility, the newly-developed materials are expected to offer continuous nutrition supply, facilitating long-term creatures storage under room temperature or in a refrigerator. For example, extracts from silk (sericin and fibroin) are demonstrated to have a variety of biological activities for promoting cellular proliferation and inhibiting apoptosis, and thus benefit tissue regeneration 109 - 111 . Researchers have started to fabricate MNAs using this kind of material for wound recovery, drug delivery, vaccination and so on 112 - 114 .…”

Advances in Medical Wearable Biosensors: Design, Fabrication and Materials Strategies in Healthcare Monitoring

“…SF has hydrophilic amide groups, hydrophobic areas, and multiple functional groups, giving it the versatility to be conjugated with various filler materials. It has been integrated with gold nanoparticles [ 12 ], graphene(GO) [ 174 ], CNTs [ 175 ], and polystyrene sulphonate (PEDOT: PSS) [ 176 ] for various applications—for example, skin patches for electromyography (EMG) [ 177 ], cardiac mesh electrodes [ 178 ], and textile electrodes for physiological monitoring [ 176 ]. Biocompatible and conductive hydrogels crosslinked with gelatin have led to the development of biomimetic sensors that exhibit the advantages of natural polymers with enhanced physical and electrical properties.…”