Enfermedad fúngica invasora (EFI) por hongos filamentosos en la Región de Valparaíso, Chile, desde la implementación del diagnóstico rápido de laboratorio

Cruz, Rodrigo; Alvarez, Patricio; Provoste, Felipe; Ducasse, Karen; Parraguez, Marcela; Wilson, George D.; Díaz, Javier

doi:10.4067/s0716-10182015000300012

Cited by 4 publications

(8 citation statements)

References 16 publications

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“…In our laboratory, the frequency of these diseases is high, with histoplasmosis being the most frequent IFD, followed by aspergillosis, cryptococcosis, pneumocystosis, PCM, invasive candidiasis, and less frequently, IFD caused by other emerging agents including some basidiomycetes and mucorales. Several publications related to IFD based on different methodological designs (prospective, retrospective, multicentric) and different patient populations (onco-hematological, transplant, intensive care unit) have reported for countries in Europe and the Americas a greater frequency of patients with invasive candidiasis and aspergillosis, which is different from the findings observed in our study [2,5,[18][19][20][21].…”

Section: Discussioncontrasting

confidence: 99%

“…In our study, histoplasmosis, aspergillosis, and pneumocystosis showed an increasing trend in the number of cases, possibly due to the fact that during the time in which this study was conducted, new methods were implemented for the detection of antigens and molecular diagnostic assays, methods that are characterized for having higher sensitivity values compared with conventional methods [14,15,[26][27][28][29][30]33,34,36]. In most studies, reports of patients with invasive candidiasis have been reported to be more frequent than what we found in our study [4,5,[10][11][12]. This may be explained by the fact that our laboratory is not affiliated with a hospital, where the majority of cases of invasive candidiasis arise.…”

Section: Discussionmentioning

confidence: 48%

“…These ranges can depend on the type of sample, the immunological status, the moment of diagnosis of the infection, and the limitations inherent to the time of reporting the results. These are, however, vital for determination of in vitro sensitivity to antifungal agents [5,26].…”

Section: Discussionmentioning

confidence: 99%

“…These individuals have a greater susceptibility to opportunistic fungal infections caused by various fungal genera (Candida, Aspergillus, Histoplasma, Cryptococcus, Talaromyces, Emergomyces, Pneumocystis, Mucorales, Fusarium, Scedosporium, etc. ), many of which are more virulent and frequently associated with antifungal resistance [2][3][4][5].…”

Section: Introductionmentioning

confidence: 99%

“…Subsequently, in 2011, there was an analysis of a five-year (2004-2009), during which 51 episodes of IFD were identified, predominately cases of candidiasis and aspergillosis [4]. Finally, in 2015, the results corresponding to a period of three years were published (2011-2014), during which the study identified a total of 18 patients diagnosed with IFD caused by filamentous fungi, predominantly from genera Rhizopus and Sarocladium [5]. In Mexico, two studies described the frequency of IFD.…”

Section: Introductionmentioning

confidence: 99%

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Frequency of Invasive Fungal Disease in Adults: Experience of a Specialized Laboratory in Medellín, Colombia (2009–2015)

Valencia

Cáceres

Bedout

et al. 2020

JoF

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Invasive fungal diseases (IFD) contribute significantly to worldwide morbidity and mortality, but their frequency is not well-described in some countries. The present work describes the frequency of IFD in a specialized laboratory in Colombia. A retrospective, descriptive study was implemented between March 2009 and December 2015. Results: 13,071 patients with clinical suspicion of IFD were referred during the study period, from which 33,516 biological samples were processed and analyzed using 14 laboratory methods. Diagnosis was confirmed in 1425 patients (11%), distributed according to the mycoses of interest analyzed here: histoplasmosis in 641/11,756 patients (6%), aspergillosis in 331/10,985 patients (3%), cryptococcosis in 239/8172 patients (3%), pneumocystosis in 111/1651 patients (7%), paracoccidioidomycosis in 60/10,178 patients (0.6%), and invasive candidiasis in 48/7525 patients (0.6%). From the first year of the study period to the last year, there was a 53% increase in the number of cases of IFD diagnosed. Our laboratory experienced a high frequency of IFD diagnosis, possibly attributable to the availability of a greater range of diagnostic tools. Frequency of IFD in this study was atypical compared with other studies, probably as a result of the single laboratory-site analysis. This demonstrates that implementing educational strategies helps to create a high index of clinical suspicion, while the availability and utilization of appropriate diagnostic assays assure greater reliability in identification of these cases.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 48%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Frequency of Invasive Fungal Disease in Adults: Experience of a Specialized Laboratory in Medellín, Colombia (2009–2015)

Valencia

Cáceres

Bedout

et al. 2020

JoF

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Mucormycosis in South America: A review of 143 reported cases

Nucci

Engelhardt

Hamed

2019

Mycoses

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SummaryMucormycosis is a rare but important invasive fungal disease that most often affects immunocompromised hosts. The incidence of mucormycosis appears to be increasing worldwide, as risk factors such as the use of immunosuppressive therapies become more common. We report the results of a literature review of 143 mucormycosis cases reported in South America between 1960 and 2018. The number of reported cases has increased by decade, from 6 in the 1960s to 51 in the 2010s. The most common underlying conditions associated with mucormycosis in South America were diabetes mellitus (42.0%) and penetrating trauma/burns (20.0%). Underlying conditions involving immunosuppression, including treatment of haematologic malignancy, solid organ transplant, and corticosteroid use, also accounted for a large proportion of cases (45.5%). Between 1960 and 2018, cases of mucormycosis associated with conditions involving immunosuppression accounted for the highest mortality rate (58.5%), followed by diabetes mellitus (45.0%), and penetrating trauma/burns (37.9%). Overall mortality decreased from 100% to 39.4% during this period, mainly driven by the increasing availability and use of antifungal therapies and surgical intervention. However, these treatments are not yet universally utilised across the region in the treatment of mucormycosis; efforts to improve availability of effective treatments would be likely to improve outcomes.

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Epidemiología de la enfermedad fúngica invasora por hongos filamentosos en el período 2005 a 2015, en un hospital universitario en Santiago, Chile

Valenzuela

Legarraga

Rabagliati

2019

Rev. chil. infectol.

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Enfermedad fúngica invasora (EFI) por hongos filamentosos en la Región de Valparaíso, Chile, desde la implementación del diagnóstico rápido de laboratorio

Cited by 4 publications

References 16 publications

Frequency of Invasive Fungal Disease in Adults: Experience of a Specialized Laboratory in Medellín, Colombia (2009–2015)

Frequency of Invasive Fungal Disease in Adults: Experience of a Specialized Laboratory in Medellín, Colombia (2009–2015)

Mucormycosis in South America: A review of 143 reported cases

Epidemiología de la enfermedad fúngica invasora por hongos filamentosos en el período 2005 a 2015, en un hospital universitario en Santiago, Chile

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