Energy and dose considerations for diffraction enhanced CT in small animal studies

Connor, Dean M.; Dilmanian, F.A.; Parham, Christopher; Kao, T.; Zhong, Zhong

doi:10.1117/12.710309

Cited by 2 publications

(2 citation statements)

References 11 publications

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“…DEI has also been shown to have contrast advantages over standard radiography for the imaging of soft tissue in joints (Li et al 2004, Majumdar et al 2004, 2004a, 2004b, Wagner et al 2004. Other studies have been done for testing DEI's effectiveness in imaging kidneys (Gang et al 2004), the brain (Mannan et al 2004, Connor et al 2007, 2009, the thyroid (Rocha et al 2004) and bone (Connor et al 2005, 2006, Wagner et al 2006, Majumdar et al 2004. Of these experiments, three are particularly pertinent to this study.…”

Section: Diffraction-enhanced Imaging Experimentsmentioning

confidence: 99%

Comparison of diffraction-enhanced computed tomography and monochromatic synchrotron radiation computed tomography of human trabecular bone

Connor¹,

Hallén²,

Lalush³

et al. 2009

Phys. Med. Biol.

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Diffraction-enhanced imaging (DEI) is an x-ray-based medical imaging modality that, when used in tomography mode (DECT), can generate a three-dimensional map of both the apparent absorption coefficient and the out-of-plane gradient of the index of refraction of the sample. DECT is known to have contrast gains over monochromatic synchrotron radiation CT (SRCT) for soft tissue structures. The goal of this experiment was to compare contrast-to-noise ratio (CNR) and resolution in images of human trabecular bone acquired using SRCT with images acquired using DECT. All images were acquired at the National Synchrotron Light Source (Upton, NY, USA) at beamline X15 A at an x-ray energy of 40 keV and the silicon [3 3 3] reflection. SRCT, apparent absorption DECT and refraction DECT slice images of the trabecular bone were created. The apparent absorption DECT images have significantly higher spatial resolution and CNR than the corresponding SRCT images. Thus, DECT will prove to be a useful tool for imaging applications in which high contrast and high spatial resolution are required for both soft tissue features and bone.

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Section: Diffraction-enhanced Imaging Experimentsmentioning

confidence: 99%

Comparison of diffraction-enhanced computed tomography and monochromatic synchrotron radiation computed tomography of human trabecular bone

Connor¹,

Hallén²,

Lalush³

et al. 2009

Phys. Med. Biol.

View full text Add to dashboard Cite

show abstract

“…imaging through the skull (Connor et al, 2007), but in vivo studies with living transgenic mice have yet to be performed.…”

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confidence: 99%

Computed tomography of amyloid plaques in a mouse model of Alzheimer's disease using diffraction enhanced imaging

et al. 2009

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Our understanding of early development in Alzheimer's disease (AD) is clouded by the scale at which the disease progresses; amyloid beta (Aβ) plaques, a hallmark feature of AD, are small (∼50 μm) and low contrast in diagnostic clinical imaging techniques. Diffraction enhanced imaging (DEI), a phase contrast x-ray imaging technique, has greater soft tissue contrast than conventional radiography and generates higher resolution images than magnetic resonance microimaging. Thus, in this proof of principle study, DEI in micro-CT mode was performed on the brains of AD-model mice to determine if DEI can visualize Aβ plaques. Results revealed small nodules in the cortex and hippocampus of the brain. Histology confirmed that the features seen in the DEI images of the brain were Aβ plaques. Several anatomical structures, including hippocampal subregions and white matter tracks, were also observed. Thus, DEI has strong promise in early diagnosis of AD, as well as general studies of the mouse brain.

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Energy and dose considerations for diffraction enhanced CT in small animal studies

Cited by 2 publications

References 11 publications

Comparison of diffraction-enhanced computed tomography and monochromatic synchrotron radiation computed tomography of human trabecular bone

Comparison of diffraction-enhanced computed tomography and monochromatic synchrotron radiation computed tomography of human trabecular bone

Computed tomography of amyloid plaques in a mouse model of Alzheimer's disease using diffraction enhanced imaging

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