Endothelin and the heart in health and diseases

Miyauchi, Takashi; Sakai, Satoshi

doi:10.1016/j.peptides.2018.10.002

Cited by 47 publications

(43 citation statements)

References 170 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The finding of elevated plasma levels of ET-1 in T2D patients was not new -this been corroborated by many other studies [26,42,43]. Among the possible pathways for cerebrovascular damage are: lipid peroxidation and nuclear factor κB activation, differential regulation of matrix metallo-proteinases and collagen synthesis, and further numerous causes listed in other studies [22,24,[44][45][46]. As the case with ADMA, good glycemic control might ameliorate the effect of plasma ET-1 on the brain vessels [47,48] while medical literature provides several examples for a link between ET-1 and myocardial perfusion [25,26,49,50].…”

Section: No Model Availablementioning

confidence: 58%

Cardiovascular Biomarkers and Calculated Cardiovascular Risk in Orally Treated Type 2 Diabetes Patients: Is There a Link?

et al. 2020

View full text Add to dashboard Cite

AbstractThe aim of the study was to test the correlation of serum levels of asymmetric dimethylarginine (ADMA), endothelin 1 (ET-1), N-terminal brain natriuretic pro-peptide (NT-proBNP), and placental growth factor (PIGF-1) with estimated cardiovascular (CV) risk. The study group was composed of 102 women and 67 men with type 2 diabetes, having their glycemic and metabolic parameters assessed. All were on oral antidiabetic drugs. Serum levels of NT-proBNP and PIGF-1 were measured by electro-hemi-luminescence on an Elecsys 2010 analyzer. Enzymatic immunoassays were used for ADMA and ET-1. The Framingham Risk Score (FRS), the UKPDS 2.0 and the ADVANCE risk engines were used to calculate cardiovascular risks while statistical analysis was performed on SPSS. Levels of PIGF-1 showed no correlation with the calculated CV risks. The same was true for ADMA, except for a weak correlation with the UKPDS-based 10-year risk for stroke (Pearsons’s R=0.167, p=0.039). Plasma levels of ET-1 were correlated with the UKPDS-based 10-year risk for stroke (R=0.184, p=0.032) and fatal stroke (R=0.215, p=0.012) only. NT-proBNP was significantly correlated with all CV risk calculations: ADVANCE-based 4-yr risk (Spearman’s Rho=0.521, p<0.001); UKPDS-based 10-year risk for: CHD (Rho=0.209, p=0.01), fatal CHD (Rho=0.282, p<0.001), stroke (Rho=0.482, p<0.001), fatal stroke (Rho=0.505, p<0.001); and 10-year FRS risk (Rho=0.246, p=0.002). In conclusion, ADMA and PIGF-1 did not seem useful in stratifying CV risk while ET-1 is linked to the risk of stroke, and NT-proBNP to all CV risk estimations.

show abstract

Section: No Model Availablementioning

confidence: 58%

Cardiovascular Biomarkers and Calculated Cardiovascular Risk in Orally Treated Type 2 Diabetes Patients: Is There a Link?

et al. 2020

View full text Add to dashboard Cite

show abstract

“…EDN1 encodes endothelin-1 and is activated by hypoxia [31]. When stimulated, it leads to vasoconstriction [32,33] and over time it can generate pulmonary arterial hypertension since it also causes a positive iono-and chronotropic effect on the heart [33]. Consequently, it is known to play a role in heart failure [34,35].…”

Section: Discussionmentioning

confidence: 99%

Gene variants associated with obstructive sleep apnea (OSA) in relation to sudden infant death syndrome (SIDS)

et al. 2021

View full text Add to dashboard Cite

Background Both obstructive sleep apnea (OSA) and (at least a fraction of) sudden infant death syndrome (SIDS) are associated with impaired respiration. For OSA, an association with several gene variants was identified. Therefore, our hypothesis is that these polymorphisms might be of relevance in SIDS as well. Methods Twenty-four single nucleotide polymorphisms (SNPs) in 21 candidate genes connected to OSA, were genotyped in a total of 282 SIDS cases and 374 controls. Additionally, subgroups based on factors codetermining the SIDS risk (age, sex, season, and prone position) were established and compared as well. Results Two of the analyzed SNPs showed nominally significant differences between SIDS and control groups: rs1042714 in ADRB2 (adrenoceptor beta 2) and rs1800541 in EDN1 (endothelin 1). In the subgroup analyses, 10 further SNPs gave significant results. Nevertheless, these associations did not survive adjustment for multiple testing. Conclusions Our results suggest that there might be a link between SIDS and OSA and its resulting respiratory and cardiovascular problems, albeit this predisposition might be dependent on the combination with other, hitherto unknown gene variants. These findings may encourage replication studies to get a better understanding of this connection.

show abstract

“…The vasoconstrictive pathway of ET A receptors includes: Coupling to phospholipase C (PLC) via GTP-binding protein, phospholipase C activation, phosphatidyl inositol hydrolysis, inositol 1,4,5 triphosphate (IP3) generation and 1,2-diacylglycerol (DCG) accumulation. Inositol triphosphate is a signalling molecule that leads to mobilisation of Ca 2+ from intra-and extra-cellular sources resulting in long-lasting vasoconstriction [56,64].…”

Section: Endothelin-1 (Et-1) Receptormentioning

confidence: 99%

“…Moreover, the ET B receptors have a natriuretic action causing sodium and water resorption from the distal tubules and collecting ducts in the kidney. The ET B receptors, which occur in smooth muscle cells, additionally act as vasoconstrictors [57,63,64].…”

Section: Endothelin-1 (Et-1) Receptormentioning

confidence: 99%

The Function of Seven Transmembrane Receptors in the Cardiovascular System and Their Role in the Development of Cardiomyopathy

Kubale¹,

Prozorowska²,

Glocová³

et al. 2021

Cardiac Diseases - Novel Aspects of Cardiac Risk, Cardiorenal Pathology and Cardiac Interventions

View full text Add to dashboard Cite

The G-protein-coupled receptors (GPCRs, also called seven-transmembrane receptor, 7TMRs, or heptahelical receptor) are a conserved family of seven transmembrane receptors which are essential not only in the healthy heart and blood vessels but also in for treatment and therapy of cardiovascular disease and failure. Heart failure is a global leading cause of morbidity and death and as such understanding 7TMRs, their functions, structures and potential for therapy is essential. This review will investigate the roles of the receptors in the healthy functioning cardiovascular system, and in cardiac disorders with an emphasis in cardiomyopathy. It will also explore the role of autoimmunity and autoantibodies against the G-protein-coupled receptors in cardiomyopathy.

show abstract

Endothelin and the heart in health and diseases

Cited by 47 publications

References 170 publications

Cardiovascular Biomarkers and Calculated Cardiovascular Risk in Orally Treated Type 2 Diabetes Patients: Is There a Link?

Cardiovascular Biomarkers and Calculated Cardiovascular Risk in Orally Treated Type 2 Diabetes Patients: Is There a Link?

Gene variants associated with obstructive sleep apnea (OSA) in relation to sudden infant death syndrome (SIDS)

The Function of Seven Transmembrane Receptors in the Cardiovascular System and Their Role in the Development of Cardiomyopathy

Contact Info

Product

Resources

About