Endothelin-1 levels and albuminuria in patients with type 2 diabetes mellitus

Zanatta, Claudete Maria; Gerchman, Fernando; Burttet, Lucas Medeiros; Nabinger, Gustavo Baldino; Jacques-Silva, M. Caroline; Canani, Luís Henrique Santos; Gross, Jorge Luiz

doi:10.1016/j.diabres.2007.12.024

Cited by 50 publications

(41 citation statements)

References 32 publications

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“…In contrast to our study, earlier studies showed relationships between ET-1 and albuminuria [33,36]. However, those studies mostly included either elderly individuals or patients with established renal disease, which may influence the described association there [37].…”

Section: Discussioncontrasting

confidence: 51%

Plasma levels of endothelin-1 and renal function among young and healthy adults

Fischer

Bossard

Aeschbacher

et al. 2017

Clinical Chemistry and Laboratory Medicine (CCLM)

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Background: Endothelin-1 (ET-1), a vasoconstrictive and pro-inflammatory peptide, is associated with several cardiovascular risk factors and outcomes. We aimed to investigate the association of plasma ET-1 levels and renal function among young and healthy adults. Methods: Individuals aged 25-41 years were enrolled in a population-based cohort study. Main exclusion criteria were established kidney disease, cardiovascular diseases, diabetes mellitus and a body mass index > 35 kg/m 2 .

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Section: Discussioncontrasting

confidence: 51%

Plasma levels of endothelin-1 and renal function among young and healthy adults

Fischer

Bossard

Aeschbacher

et al. 2017

Clinical Chemistry and Laboratory Medicine (CCLM)

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show abstract

“…37 On the other hand, in some studies there was no significant relationship between plasma concentration of ET-1 and GFR. 38 These results can partially be explained by the fact that the diabetic patients included in the studies had no significant difference in the GFR level.…”

Section: Discussionmentioning

confidence: 81%

Plasma endothelin-1 level, measured glomerular filtration rate and effective renal plasma flow in diabetic nephropathy

et al. 2015

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Background: Endothelin-1 (ET-1) is potent vasoconstrictor peptide which is able to contribute to the functional and structural renal changes. The aim of this study was to investigate the relationship between plasma concentration of ET-1 and indices of renal function in patients with diabetic nephropathy. Methods: We measured plasma ET-1 levels in 99 patients with type 2 diabetes, divided into two groups according to the values of their glomerular filtration rate (GFR): group I (GFR ! 60 mL/min/1.73 m

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“…Levels of plasma ET-1 are increased in both CKD [32] and HF [33]. In fact, in patients with diabetic nephropathy, plasma levels of ET-1 directly correlate with serum creatinine and degree of albuminuria [34]. Proteinuria alone stimulates production of ET-1 by proximal tubule cells [35] providing a direct link between worsening kidney functions and elevated ET-1.…”

Section: Pressure Overloadmentioning

confidence: 95%